A New Hepatic Test based on Onservation of Altered Membrane Properties of Erythocytes : An Aplication of Coil Planet Centrifugation to Clinical Medicine

The emolysis band appering on the helical centrifuge tube (”coil”) in coil planet centrifugation was shifted toward the side of lower osmolarity in hepatobiliary disorders. The rate of detection of hepatic dysfunction by the shifted hemolysis band was about 80 per cent, and false positive result in nonhepatobiliary diseases was 10 per cent. The mechanism by which the hemolysis band was bisplaced was studied, and it became evident that the ”Estersｔurz”. The mean shift of the hemolysis band was evident in parallel with the grade of dysfunction and damage of the hepatobiliary system, e.g. the average bias was distincter in liver cirrhosis than in hepatitis. Sequentially repeated tests on the same patients disclosed the bisa of the hemolysis band to very in satisfactorily good correlation with the advance and the recession of clinical manifestation. Accordingly, the coil planet centrifion is conceived to provide a usuful measure as a hepatic test equivalent to the estimation of ”Estersturz”. It is particularly reliable when patients are followed up.