Studies on Chromosomal Abnormalities of Leukemia and Malignant Lymphoma. Part 2. Experimental Study

Gross virus-leukemia cells were inoculated to mice subcutaneously, and chromosomal analyses were carried out in cells of bone marrow, liver and spleen. The results were as follows. Although the chromosome number was forty as mode in bone marrow cells and spleen cells in all, the former showed the tendency of hypodiploid and the latter hyperdiploid. Especially in five mice showing leukemic change pathohistologically chromosome number of bone marrow, spleen and liver cells were abnormally distributed from hypodiploid to hyperdiploid as 39, 40 and 43. No marker chromosome was recognized. These findings are discussed in relation toviral leukemogenesis.