Studies on Pepsin Activity in the Gastric Juice. Report 2. Clinical Significance on Pepsin Secretion in the gastric Diseases

This study was carried out to clarify the pepsin secretion in the gastric juice in various gastric diseases by the modified Anson's method and the following results were obtained. 1. Although the time required to reach maximal pepsin activity was faster in tetragastrin stimulation than in histalog stimulation, there was no statistical difference between the effects of histalog and of tetragastrin on the pepsin outpus. 2. Pepsin activty and 10 minute' pepsin output reached to peak value at 20 to 30 minutes after histalog stimulation. 3. Positive correlation was demonstrated between the amounts of pepsin and of acid secreted in an hour. 4. The gastric pepsin outpus was the highest in the cases of duodenal ulcer and the lowest in the cases of ATP. 5. Gastric ulcer of the pyloric portion showed higher pepsin outpus than that of the other. 6. No change of pepsin output was found in the course of peptic ulcer than acid output. 7. The pepsin secretion of the depressed gastric cancer was significally higher than that of the elevated gastric cancer. 8. The inhibitory action of antipeptic drugs on pepsin activity in vitro was paralleled with the amount of sulfate radicals contained in the drugs. The inhibitory action was remarkable and cntinued for about 40 to 50 minutes after oral administration of antipeptic drug.