Roles of heat shock transcription factor system

All organisms respond to elevated temperatures by inducing a set of proteins, termed heat shock proteins. This response is called as heat shock response. Heat shock response is mainly regulated at the revel of transcription by heat shock transcription factor (HSF). HSF is evolutionary well conserved and diverged functionally during evolution. HSFs not only regulates heat shock response, but is also involved in development, spermatogenesis, and viral infection. Moreover, molecular evolution might be under the control of HSF through Hsp90 expression.

遺伝子発見

恒常性維持

本文データは山口大学医学会の許諾に基づきCiNiiから複製したものである