Metabolism and Distribution of Chloral Hydrate in the Rat Stomach

Tissue distribution of chloral hydrate(CH) and its metabolites was investigated using adult Wistar rats, that had received CH intraperitoneally or subcutaneously. The changes in metabolite concentrations in plasma, gastric mucosa, or gastric juice, were as follows. (1) CH appeared in the gastric juice immediately after administration, and then decreased slowly. In gastric mucosa, CH increased over time. (2) Free trichloroethanol (F-TCE) appeared in the gastric juice after the administration of CH. Although F-TCE in the gastric muccsa abruptly decreased 3 h after administration, that in the gastric juice remained elevated for alongtime. (3) Conjugated trichloroethanol (Conj-TCE) appeared into the plasma immediately after the administration of CH. However, the appearance of Conj-TCE in gastric juice was delayed. (4) Appearance of trichloroacetic acid(TCA) in the gastric juice was more delayed than that in the plasma, suggesting difficulties in the transfer of TCA from plasma to gastric juice.

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胃粘膜