Evaluation for Intravenous, Arterial and Local Infusion of a Hypoxic Cell Radiosensitizer RK28 on Rabbit VX2 Tumor System.

We evaluated the radiosensitizing effect of intraarterial, intravenous and local infusion of a hypoxic cell radiosensitizer RK28 on rabbit VX2 tumor system. Six rabbits were treated in each infusion group. VX2 tumor was inplanted in the left hind leg. Tumor grown up to 3cm in diameter was treated with 15 Gy of X-ray irradiation just after infusion of radiosensitizer RK28(80 mg/kg.b.w. ). Intratumoral and serum mean concentration of RK28 and its metabolites were measured. Tumor regression curve and survival time were analysed. The following results were obtained: (1) Mean concentration of RK28 was about 2.5 times greater in local infusion and 1.5 times in intaarterial infusion than in intarvenous infuson. (2) Significant regression of tumor was obtained in intraarterial infusion(p<0.01). (3) There was no significant difference in survival time. These data suggest the usefulness of intraarterial infusion of RK28 for local control using intraoperative radiationthorapy and brachytherapy.

家兎VX2下腿腫瘍

低酸素組胞増感剤RK28

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