Clinical and Pathological Analysis of Patients with Synchronous Liver Metastases from Colorectal Cancer

Out of 511 patients with colorectal cancer, 39 patients with synchronous liver metastases were retrospectively studied. Ten patients underwent hepatic resection (RH group), 16 patient did not have hepatic resection (NRH group), and 13 patients had peritoneal dissemination (HP group). RH group including 5 HI cases underwent curative resection for colorectal primaries. The median survival time in RH group, NRH group, and HP group was 26.3 months, 7.7 months, and 8 months, respectively, with the survival curves differing significantly (p<0.03). In patients with resection with colorectal primaries, the median survival time in RH group, NRH group and HP group with systemic immunochemotherapy was 17.3 months, 6.8 months, 5.6 months, respectively and the median survival time in three groups with intrahepatic therapy was 39.2 months, 12.2 months, and 12 months, respectively. The survival rate in RH with intrahepatic therapy was significantly greater than that of other groups (p<0.05). However, the prognosis of RH group with systemic therapy was identical to other group. At present , hepatic resection with postoperative intrahepatic therapy for colorectal metastases may provide the only potential method of salvage.

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