山口医学

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山口医学 Volume 40 Issue 1
published_at 1991-02

The mode of action of lithium and caffeine in stressed rats

ストレス状況下におけるリチウムの作用
Ushijima Itsuko
Inano Syu
Kajimura Naofumi
Hara Takahide
Mizuki Yasushi
Yamada Michio
Descriptions
This study investigates the ability of lithium and acaffeine on both struggling responses and gastric lesions induced by immnobilization stress. When rats were exposed to immobilization stress, struggling responses such as tail flipping and vocalization, and defecation initially appeared, wheras a decrease of struggling responses with concomitant gastric lesions occurred later. Lithium choraide (50, 100 mg/kg i.p.) significantly attenuated these responses during immobilization stress in a dose-dependent manner. A potent adenosine A_1 receptor stimulant, N^6-cyclohexyl adenosine (CHA