Experimental studies on impairment of glucose tolerace after major pancreatectomy with total gastrectomy

The first experiment was designed to clarify the effect of preserving total stomach on impaired glucose tolerance after major pancreatectomy in rats. The animals were divided into the following three groups : group I (laparotomy), group II (85% distal pancretectomy), and group III (85% pancreatectomy with total gastrectomy). Four weeks after the operation, intravenous glucose tolerance tests were performed. In group III, glucose tolerance and insulin release were most impaired among three groups. It can be concluded that preservation of the total experiment was performed to study the effective for saving the impaired glucose tolerance after major pancreatectomy. The second experiment was performed to study the effect of oral administration of typsin inhibitor on the impaired glucose tolerance observed in the first experiment. By means od typsin inhibitor administration, a significant increase in the tissue weight was demonstrated in the remnant pancreas after both major pancreatecomy and major panceratectomy with total gastrectomy, and the impaired glucose tolerance tended to be improved.