During the past 4 years, 41 patients with hepatocellular carcinoma were treated in our clinic. Ninety precent od these patients had mild or severe liver dysfunction due to cirrhosis or chronic hepatitis, and the various types of liver resections were performed on 39 patients. The cummulative 3-years survival rate excluding the postoperative death cases was 75 percent. The intra-artetial infusion immunochemotherapy using totally implanted drug delivery system was further perdormed on five patients with noncurative surgery, among whom a 57-year-old woman showed complete response to intra-srtetially administered recombinant interleukin-2.