Study on experimental atrophic gastrits of rats by peroral administration of TCA or MNNG

This experment was figured out in order to make sure the etiology of atrophic gastritis. Taurochoria acid (TCA) and N-methy-N'-nitro-N-nitrosoguanidine (MNNG), which are known as reagent inducing atrophic change in the stomach of experimental animals, were adiministrated orally with drinking water into the rats. The rats were sacrificed for histologial study at the several critical points such as 1st, 3rd, 6th, and 10th month. In sonclusion, decrease of parietal cell number, shortening of the lengh of grastric mucosa, increace of fibrosis and infiltlation of inflammatory cells at the interstium were seen characteristically at the glandular stomach of the rats, in which TCA or MNNG was given for 6 or 10 months. Those histokogicak dhanges were as if atrophic gastritis seen in human stomach. Therefore, it seems that this experimental design will be suitable for the study on atrophic gastritis in human.