By the clinical study of the effect of immunosuppressive agents on the treatment of autoimmune dermatosis, such as pemphigus, pemphigoid and SLE, the following results were obtained. Azathiopurine were found to be useful as an adjunct of corticosteroid in 7 of the 9 patients with pemphigus, one of the 2 patients with pemphigoid and 4 of the 7 patients with SLE, and Mizoribine in one of the 4 patients with pemphigus and 2 of the 2 patients with pemphigoid. Cyclophosphamide was not useful in one patient with pemphigus and in one patient with SLE.