Study of an Intravenous Fat Tolerance Test with Intralipid Rate. -Evaluation of Fractional Turnover Rate of ntralipid Rate and Post Heparin Lipolytic Activity-

Clinical entity of the K2 Value (triglyceride fractional turnover rate) obtained by Intravenous Fat Tolerance Test with Intratipid rate has been investigated with reference to PHLA (post heparin lipolytic activity). After intravenous injection of Intralipid rate, FFA (free fatty acid in sera), especially linolelc acid composing large part of Intralipid rate triglyceride, increases according to intravascular lipolysis, and disappearans of the increased FFA delays in type Ⅱb or type Ⅳhyperlipidemia, in whom k2 is abnormally low althoughPHLA is normal. Statistical analysis indicates an inverse partial correlation between K2 and fasting triglyceride level, and between K2 and age, but no partical correlation between K2 and PHLA is found. It is suggested by Multiple Regresion Analysis or Principle Component Analysis that the variation of K2 is closely related to serum triglyceride level and degree of obesity, while PHLA related to serum albumin level. It is quite possible that K2 reflects abnormality of lipid transport and K2 is, at least partly, independent of PHLA, and that also characteristic clinical informations are given by K2 measurement.