The difference of floatability between copper and zinc sulfide minerals is comparatively small, therefore, zinc content in copper concentrate is comparatively large in common floatation process. Author intended to improve this defect by using zithzone as collector. Main results obtained are as follows. 1) Zithizone has comparatively strong collecting action on copper and zinc sulfide minerals and its consumption is about 1 gm per ton. 2) In order to decrease zinc content in copper concentrate, it is necessary to use sodium cyanide, zinc sulfate and hydrogen sulfide as depressing reagent, and also to regulate the concentration of hydrogen sulfiide in pulp in a narrow range. 3) A pH of 4.5 to 5 is recommended for copper circuit