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Effect of monoclonal antibody against tnf-alfa on noise-induced inner ear damage

Medical Science & Innovation Volume 71 Issue 1-2

This study investigated the potential of adalimumab (ADA), a monoclonal antibody targeting TNF-alfa, to protect the inner ear from intense sound exposure, given that inflammatory cytokines, including TNF-alfa, are linked to hearing loss in acoustic disorders. In this study, adalimumab was administered to mice, and its effect on the inner ear was assessed. We examined the translocation of ADA to the inner ear and its ototoxicity and impact on acoustic exposure. The results showed that adalimumab partially reached the cochlea after administration but increased the susceptibility to acoustic exposure, resulting in higher hair cell loss in the inner ear. While TNF-alfa had been considered a potential therapeutic target, the results suggested that excessive TNF-alfa suppression could harm the inner ear. We acknowledged some limitations, such as the use of adalimumab instead of an anti-mouse TNF-alfa antibody and the need to explore the suppression of other cytokines for better inner ear protection. In conclusion, adalimumab administration was found to increase the inner earʼs susceptibility to acoustic exposure, potentially leading to more significant hair cell damage, possibly due to excessive TNF-alfa suppression

Creators : 山本陽平 | Sugahara Kazuma | Tsuda Junko | Hashimoto Makoto | Yamashita Hiroshi Publishers : Yamaguchi University School of Medicine Date Issued : 2024-06

Nobiletin protects hair cells against neomycin-induced vestibular hair cell death

Medical Science & Innovation Volume 71 Issue 1-2

Vestibular hair cells are susceptible to damage from various stimuli such as infections, ischemia, and certain therapeutic drugs, including aminoglycoside antibiotics and the antineoplastic agent cisplatin. In mammals, damage to the vestibular hair cells is permanent. This study aimed to evaluate the protective effects of nobiletin (NOB) against aminoglycoside-induced hair cell death using utricles collected from adult mice. The utricles removed from CBA/N mice were assigned to eight groups according to the dose of NOB and the administration or not of neomycin. Hair cells in the utricles were counted by double labeling with calmodulin and calbindin. NOB inhibited hair cell death in utricles exposed to neomycin. The protective effect of NOB on hair cells in the utricles was also suggested to have resulted from the inhibition of the production and accumulation of 4-hydroxy-2-nonenal, the final product of lipid peroxide aldehyde. NOB suppressed neomycin-induced hair cell death. The principle of hair cell protection from aminoglycoside-induced hair cell death suggests that NOB inhibits reactive oxygen species formation in the utricles exposed to neomycin.

Creators : Masaki Tatsuya | Sugahara Kazuma | Hashimoto Makoto | Yamashita Hiroshi Publishers : Yamaguchi University School of Medicine Date Issued : 2024-06

Relationship of uric acid and uric acid to creatinine ratio with reduced glomerular filtration rate in non-alcoholic fatty liver disease among apparently healthy adults

Medical Science & Innovation Volume 71 Issue 1-2

Objective: The objective was to explore the potential existence and nature of the relationship between serum of uric acid (SUA) and serum uric acid to serum creatinine ratio (SUA/SCr) with reduced estimated glomerular filtration rate (eGFR) in patients with non-alcoholic fatty liver disease (NAFLD). Methods: A cross-sectional study was conducted among apparently healthy subjects with NAFLD (n=485). The association between tertiles of SUA and SUA/SCr with reduced eGFR (n=56) were investigated after adjustments for potentially relevant confounders. Also, the diagnostic performances of SUA and SUA/SCr were evaluated with the receiver operating characteristic (ROC) curve analysis. Results: In the adjusted models, SUA showed a significant positive association with reduced eGFR in the highest tertile (OR 5.65, 95% CI 2.48-12.86, p<0.001), and SUA/SCr, in the lowest tertile (4.21, 95% CI 1.76-10.07, p=0.001). The ROC curve analysis did not reveal any significant difference between the corresponding values of area under the curve for SUA and SUA/SCr (0.70 and 0.67, respectively; p=0.521). Conclusions: We revealed significant and independent associations of elevated SUA and reduced SUA/SCr with kidney function decline in NAFLD. However, the clinical utility of these two biomarkers seemed to be limited for the mentioned purpose and needs further investigations.

Effect of defective calcium metabolism on otolith formation in zebrafish

Medical Science & Innovation Volume 71 Issue 1-2

Benign paroxysmal positional vertigo (BPPV) is the most common vertigo disease and is more likely to occur in perimenopausal women, suggesting an association with osteoporosis. Since otoconia are primarily composed of calcium carbonate, abnormal calcium metabolism may lead to otoconia dislocation. However, the detailed mechanism is currently unknown. In this study, we investigated the effects of drugs (cadmium and dexamethasone) that cause abnormal calcium metabolism on otolith formation in zebrafish larvae. Here, otolith size was clearly reduced in the cadmium group, and the calcium content of the larvae was also markedly reduced. In contrast, in the dexamethasone group, which also had a lower calcium content than the control group, otolith size increased. Our results suggest that, as in bone, calcium metabolism influences the repeated dissolution and recrystallization of otoliths and maintains homeostasis in response to calcium concentrations in the endolymphatic fluid.

Creators : Iwamoto Aya | Sugahara Kazuma | Hashimoto Makoto | Yamashita Hiroshi Publishers : Yamaguchi University School of Medicine Date Issued : 2024-06

On the right not to be discriminated against

Yamaguchi journal of economics, business administrations & laws Volume 72 Issue 6

Creators : Kajiwara Kensuke Publishers : The Economic Society of Yamaguchi University Date Issued : 2024-03-31

The legal definition of academic harassment and power harassment

Yamaguchi journal of economics, business administrations & laws Volume 72 Issue 6

Creators : Yanagisawa Noboru Publishers : The Economic Society of Yamaguchi University Date Issued : 2024-03-31

The authenticity of the famous Japanese legend, “abolition of the prohibition law on eating pufferfish in Yamaguchi Prefecture by the first prime minister Hirofumi Ito” : a mystery in the history of pufferfish food hygiene in the Meiji Era

Yamaguchi journal of economics, business administrations & laws Volume 72 Issue 6

Creators : Furukawa Sumiaki Publishers : The Economic Society of Yamaguchi University Date Issued : 2024-03-31

Why do Japanese menus have images? Japanese auto-scopophilia is massage not message

Yamaguchi journal of economics, business administrations & laws Volume 72 Issue 6

本研究では、日本のレストランのメニューにはイメージが多い理由を探るために、未知の食事の内容を映像的に知らせるため・映像のなさで高級であることを発信するためという情報伝達仮説と、来客の行動を客体化し欲望を高めるという「マッサージ」（McLuhan、1957）仮説を検証した。情報伝達仮説はいずれも支持されなかったが、マッサージ仮説が有意に支持されたので、既知且つ高級な料理の場合でも、メニューに映像を掲載することを推薦した。

Creators : Takemoto Timothy | Yamauchi Takuma | Horii Kousei | Matsumura Kanta Publishers : The Economic Society of Yamaguchi University Date Issued : 2024-03-31

Work intentions and working conditions of nurses in the field of long-term care insurance services

Yamaguchi journal of economics, business administrations & laws Volume 72 Issue 6

Creators : Tsunoda Yuka Publishers : The Economic Society of Yamaguchi University Date Issued : 2024-03-31

Input-output analysis of China's plastic import ban

Yamaguchi journal of economics, business administrations & laws Volume 72 Issue 6

This study uses the International Input-Output Table to estimate the impact on Japan of China's ban on the import of waste plastics implemented at the end of 2017. Initially, by employing an econometric model, it was estimated that Japan's total waste plastic emissions decreased by an average of 39,000 tons from 2018 to 2022 due to China's ban on waste plastic imports. This reduction corresponds to 0.46% of the average annual total waste plastic emissions. Assuming a proportional relationship between Japan's total waste plastic emissions and domestic production, it was projected that the domestic production would decrease by an average of 0.46% annually. Furthermore, due to the anticipated decrease in Japan's production leading to a reduction in the import of intermediate goods from China and other countries, the study used the modified Leontief inverse matrix derived from the International Input-Output Table to calculate the negative economic multiplier effects （decrease in production） on China and other countries resulting from the decrease in Japan's production. As a result, we showed that, on average, from 2018 to 2022, China's ban on waste plastic imports had a negative economic multiplier effect of 4.2 trillion yen in Japan, 119.5 billion yen in China, and 5.0 trillion yen in the world.

Creators : Kato Shinya | Kojima Hisashi Publishers : The Economic Society of Yamaguchi University Date Issued : 2024-03-31

A macroeconomic model considering government bond yield, loan interest rate and deposit interest rate

Yamaguchi journal of economics, business administrations & laws Volume 72 Issue 6

In IS-LM model, it seems difficult to intuitively understand the concept of money market. Therefore, in Umada（2024） we discussed the determination of loan interest rate, deposit interest rate, and government bond yield without using the concept of money market. In addition to these three, we will also discuss GDP and price determination, adding the concept of goods market to the discussion.

Creators : Umada Tetsuji Publishers : The Economic Society of Yamaguchi University Date Issued : 2024-03-31

表紙・目次ほか

Yamaguchi journal of economics, business administrations & laws Volume 72 Issue 6

Publishers : The Economic Society of Yamaguchi University Date Issued : 2024-03-31

Initiatives for a new chemical substance management system