Osteogenic differentiation of the spinal ligament derived cells by dexamethasone

Given the pathogenesis of ossification of the spinal ligament has been shown to be associated with osteogenic differentiation of spinal ligament cells, cells derived from human yellow ligament of the spine were investigated for their ability to develop osteoblast phenotypic markers in the presence of dexamethasone. Growth of the ligament cells was suppressed by the addition of dexamethasone at a high concentration (10^6 M). Dexamethasone increased alkaline phosphatase activity and mRNA levels of alkaline phosphatase and pro-α(I) collagen, suggesting that human spinal ligament consists of a heterogeneous population of cells including immature multipotential cells as well as committed fibroblasts, and that dexamethasone has a possible involvement in the osteoblastic differentiation of the former cells.

脊椎靭帯骨化

骨芽細胞

分化

デキサメサゾン

本文データは山口大学医学会の許諾に基づきCiNiiから複製したものである