Study on cerebral infartion in the deep nondortical region

Ischemic cerebrovascular disorder is highly represented by cerebral infarction in the deep noncortical region of the internal carotid arterial system, and our examination revealed a frequency of about 47%, which is higher than that so far reported. On this occasion, with a view to elucidating the morbid condition of the above cerebral infarction and establishing an adequate therapeutic plan, we have comparatively examined clinical pictures and serebral angiographical findings of the above cerebral infarction and those in the cortical region. Many cases presented no abnormal findings in cerebral angiograms, so that arteriosclerotic changes in the penetrating branch arteries were supposed to be basically responsible for the above cerebral infarction. Its frequent occurrence in the morning suggested its relationship with platelet hyperaggregability, though platelet aggregatometry was rather difficult to give support thereto. The above cerebral infarction generally shows good functional prognosis indeed, but appropriate conservative therapy is needed for the prevention of aggravation and/or relapse of neurological symptoms. It was thought that not only platelet aggregability inhibiting agent but also hemodilution treatment were necessary at its acute stage and maintenance therapy with Aspirin (optimum dose : 160-80mg/day) was needed at its chronic stage.