Effects of Human Fibroblast Interferon on Natural Killer (NK) Activities of 2 Patients with B Type Chronic Active Hepatitis

Human fibroblast interferon (HFIF) was parenterally administered to two patients for 28 days. Two patients were diagnosed as chronic active hepatitis by liver biopsy, and had persistently positive HBsAg and HBeAg. They were R. Y. 23 years old male and K. H. 40 years old male. Total dosage of HFIF was 10.5×10^7 IU. Natural killer (NK) activity of peripheral blood lymphocytes and HBV markers were examined during administration of HFIF. NK activities of both patients had a tendency to fall. HBeAg became negative and a rise of HBeAb titer was found in case R. Y. But, HBsAg titer decreased little, and DNA-P activity had been negative before administration. In case K. H., DNA-P activity decreased transiently at 7th day after administration, but other HBV markers did not change. Transient thrombocytopenia, leukocytopenia and pyrexia were found during administration, but recovered promptly after the end of administration.