Thyroid scintigraphy and the clinical evaluation during recent several years in department of radiology, Yamaguchi University Hospital were discussed : The transition of radionuclides, the comparison with scintigraphic finding and pathological patterns of patients, and the use of various radionuclides were studied. In thyroid scintigraphy, scanning with single radionuclide is very difficult to achieve the accurate diagnosis. The adequate combination of various radionuclide is preferable for the determination of diagnosis. The result of study suggest us that the adequate combination of various nuclide (NA^131I ^<99m>TcO_4 and ^<201>Tl-chloride) is preferable for the determination of diagnosis. Medical literature were discussed.