The purpose of this paper is to make clear the origin of electrical resistance change in the growth and fermentation process of baker's yeast. Culture cells are freshly made in order to cultivate yeast in one compartment while keeping yeast free from the other compartment. The two compartments CH1 and CH2 are separated from each other by a nuclepore membrane with about 1 micron pore size. CH1 is the cultivation cell, and CH2 is used to monitor the resistance change in the solution ions due to the components diffusing through the intermediate membrane. The electrical resistances R1 and R2 of CH1 and CH2,respectively, are simultaneously measured by four electrodes. To see the role of carrier ion components