Contents Menu
resource typedepartmental bulletin paper
Result 15481 Items
Id (<span class="translation_missing" title="translation missing: en.view.desc">Desc</span>)
Creators : Nakano Hiroyuki | Mano Takamitsu | Mishima Katsuaki | Kishi Masami | Horinaga Daijyu | Miyawaki Yuichiro | Mori Yoshihide | Ueyama Yoshiya Publishers : Yamaguchi University School of Medicine Date Issued : 2012
Creators : Yamashiro Yasuhiro | Hattori Yukio | Nitta Takenori | Adhiyanto Chris | Matar Maryam M. | Ferania Mella | Takagi Fumiya Publishers : Yamaguchi University School of Medicine Date Issued : 2012
Melatonin protects oocyte from reactive oxygen species
The bulletin of the Yamaguchi Medical School Volume 59 Issue 3-4
Creators : Tamura Hiroshi | Takasaki Akihisa | Taketani Toshiaki | Tanabe Manabu  | Kizuka Fumie | Lee Lifa | Tamura Isao | Maekawa Ryo | Aasada Hiromi | Yamagata Yoshiaki | Sugino Norihiro Publishers : Yamaguchi University School of Medicine Date Issued : 2012
Focal brain cooling: revisiting a potential therapeutic option for intractable epilepsy
The bulletin of the Yamaguchi Medical School Volume 59 Issue 3-4
Creators : Fujii Masami Publishers : Yamaguchi University School of Medicine Date Issued : 2012
Creators : Fujita Motoki | Maekawa Tsuyoshi | Todani Masaki | Tsuruta Ryosuke Publishers : Yamaguchi University School of Medicine Date Issued : 2012
Catecholaminergic polymorphic ventricular tachycardia (CPVT) is an inherited disease characterized by stress- or exercise- induced ventricular tachycardia, frequently leading to sudden cardiac death. A considerable body of evidence accumulated over recent years suggests that mutation-linked cardiac ryanodine receptor (RyR2) defects cause Ca^2+ leak from sarcoplasmic reticulum, which triggers delayed afterdepolarization and leads to CPVT. However, the underlying mechanism, by which a single mutation in such a large molecule causes drastic effects on the channel function, remains elusive. Here we report that introduction of a human CPVT mutation S2246L into the mouse RyR2 induces aberrant activation of channel gating by forming abnormally tight domain-domain interaction between the S2246L mutable domain and the K201-binding domain. This produces more global conformational change in the RyR2: namely, an aberrant domain unzipping between the N-terminal (a.a. 1–600) domain and the central (a.a. 2000–2500) domain owing to the allosteric conformational coupling mechanism. Pharmacological correction of the defective inter-domain interactions can stop the aberrant Ca^2+ release and lethal arrhythmia. These results provide a new pathogenic mechanism of CPVT and a novel therapeutic strategy against CPVT
Creators : Suetomi Takeshi | Yano Masafumi | Matsuzaki Masanori Publishers : Yamaguchi University School of Medicine Date Issued : 2012
Creators : Nagahata Minoru Publishers : 山口大学大学教育機構 Date Issued : 2012-03
Creators : Nakamizo Tomoko | Sakai Mieko | Kanamori Yumi Publishers : 山口大学大学教育機構 Date Issued : 2012-03
Creators : Tian Mei Publishers : 山口大学大学教育機構 Date Issued : 2012-03
Creators : Nagai Ryoko Publishers : 山口大学大学教育機構 Date Issued : 2012-03
J-CATmini Japanese Test : Online Trial Version
Journal of higher education Volume 9
Creators : Akagi Yayoi | Imai Shingo Publishers : 山口大学大学教育機構 Date Issued : 2011-03
Creators : Ahama Shihori | Yoshimura Makoto Publishers : 山口大学大学教育機構 Date Issued : 2012-03
Practical of a leader's summer activities
Journal of higher education Volume 9
Creators : Ahama Shihori | Hirao Motohiko | Yoshimura Makoto Publishers : 山口大学大学教育機構 Date Issued : 2012-03
Creators : Okuya Shigeru Publishers : 山口大学大学教育機構 Date Issued : 2012-03
Creators : Nakahara Ryuji | Itou Yumie | Tanaka Ayami | Miyamoto Shuichi | Kukita Yukiko | Tanaka Yukiharu | Kiya Hidekatu Publishers : 山口大学教育学部附属教育実践総合センター Date Issued : 2012-09-25
The relationship of identity style and mental health for faculty of education students
Bulletin of the Integrated Center for Education Research and Training Volume 34
Creators : Nishida Wakaba | Okibayashi Yohei Publishers : 山口大学教育学部附属教育実践総合センター Date Issued : 2012-09-25
On the environment where children can be as they are : Through a film ”I Wish” by H.Koreeda
Bulletin of the Integrated Center for Education Research and Training Volume 34
Creators : Tsuneyoshi Tetsuzo Publishers : 山口大学教育学部附属教育実践総合センター Date Issued : 2012-09-25
A review of the literature on encounter groups in Japanese schools
Bulletin of the Integrated Center for Education Research and Training Volume 34
Creators : Oshie Takashi Publishers : 山口大学教育学部附属教育実践総合センター Date Issued : 2012-09-25
Related Journals
Bulletin of the Faculty of Education, Yamaguchi University Volume 73 45 Bulletin of the Faculty of Education, Yamaguchi University Volume 68 40 Bulletin of the Faculty of Education, Yamaguchi University Volume 71 40 Bulletin of the Faculty of Education, Yamaguchi University Volume 72 39 Bulletin of the Faculty of Education, Yamaguchi University Volume 61 38 Bulletin of the Integrated Center for Education Research and Training Volume 25 37 Bulletin of the Integrated Center for Education Research and Training Volume 50 37 Bulletin of the Faculty of Education, Yamaguchi University Volume 3 Issue 1 36 Bulletin of the Faculty of Education, Yamaguchi University Volume 62 36 山口大学文学会志 Volume 49 34 Bulletin of the Faculty of Education, Yamaguchi University Volume 67 34 Bulletin of the Faculty of Education, Yamaguchi University Volume 65 33 Bulletin of the Faculty of Education, Yamaguchi University Volume 69 33 Bulletin of the Faculty of Education, Yamaguchi University Volume 4 Issue 1 32 紀要 Volume 2 32 Bulletin of the Faculty of Education, Yamaguchi University Volume 70 32 Bulletin of the Faculty of Education, Yamaguchi University Volume 60 31 Bulletin of the Faculty of Education, Yamaguchi University Volume 42 31 Bulletin of the Faculty of Education, Yamaguchi University Volume 58 31 山口大学工学部学報 Volume 4 Issue 1 30 Bulletin of the Faculty of Education, Yamaguchi University Volume 59 30 Bulletin of the Faculty of Education, Yamaguchi University Volume 64 30 山口大学教育学部研究論叢 Volume 1 Issue 2 29 山口大学工学部学報 Volume 2 Issue 1 29 Memoirs of the Faculty of Engineering, Yamaguchi University Volume 39 Issue 1 29 Memoirs of the Faculty of Engineering, Yamaguchi University Volume 40 Issue 1 29 Bulletin of the Faculty of Education, Yamaguchi University Volume 66 29 Bulletin of the Faculty of Education, Yamaguchi University Volume 43 29 Bulletin of the Faculty of Education, Yamaguchi University Volume 39 29 Bulletin of the Integrated Center for Education Research and Training Volume 54 29 山口大学工学部学報 Volume 3 Issue 1 28 山口大学医学部附属病院看護部研究論文集 Volume 84 28 Bulletin of the Integrated Center for Education Research and Training Volume 46 28 Bulletin of the Integrated Center for Education Research and Training Volume 48 28 Bulletin of the Faculty of Education, Yamaguchi University Volume 47 28 Bulletin of the Integrated Center for Education Research and Training Volume 56 28 山口生物 Volume 17 27 山口大学教育学部研究論叢 Volume 1 Issue 1 27 Memoirs of the Faculty of Engineering, Yamaguchi University Volume 32 Issue 1 27 紀要 Volume 1 27 山口大学医学部附属病院看護部研究論文集 Volume 82 27 Bulletin of the Faculty of Education, Yamaguchi University Volume 63 27 Bulletin of the Faculty of Education, Yamaguchi University Volume 50 27 山口大学教育学部研究論叢 Volume 2 Issue 1 26 Bulletin of the Faculty of Agriculture, Yamaguchi University Volume 3 26 Memoirs of the Faculty of Engineering, Yamaguchi University Volume 30 Issue 2 26 Bulletin of the Faculty of Education, Yamaguchi University Volume 41 26 Bulletin of the Faculty of Education, Yamaguchi University Volume 57 26 Bulletin of the Faculty of Education, Yamaguchi University Volume 44 25 Bulletin of the Faculty of Education, Yamaguchi University Volume 52 25
Show More
Show Less