山口医学

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山口医学 Volume 42 Issue 5
published_at 1993-10

A Comparison of Clinical Usefulness Between G-CSF and GM-CSF in Allogeneic Bone Marrow Transplantation

同種骨髄移植におけるG-CSFおよびGM-CSFの臨床的有用性
Azuno Yoichi
Hiroshige Yukio
Nishimura Manabu
OkaFuji Koichiro
Tanaka Hiroyuki
Seguchi Masato
Yodshida tsuyoshi
Inoue Yasushi
Matsumoto Noboru
Kaku Kohei
Kaneko Toshio
Descriptions
To evaluate the clinical usefulness of granulocyte colony-stimulating factor (G-CSF) and granulocytemacrophage colony-stimulating factor (GM-CSF) on a hematopoietic reconstitution after allogeneic bone marrow transplantation (BMT), the effects of CSFs on the recovery of hematopoietic cells in patients who received allogeneic BMT were examined. CSFs were administered intravenously from dayl or day5 to day21 after BMT. The posttransplant use of G-CSF or GM-CSF significantly reduced the duration of neutropenia ( <500/μl , p <0.05), [17.7±2.1 days in patients with G-CSF (mean±SD, n=7) and 17.3±0.5 days with GM-CSF (n=4), 23.2±3.9 days in patients who did not receive CSFs (n=5)]. The bone marrow smear showed a significant increase in immature myeloid cells in the patients with G-CSF or GM-CSF. A transient decrease in neutrophil numbers (rebound phenomenon) was frequently observed after the cessation of CSFs. Thus both G-CSF and GM-CSF showed the similar effects on the hematopoietic reconstitution after BMT. Oft the other hand* a number of adverse effects including fever, skin eruption, gastro-intestinal symptom and arrhythmia were noted in almost all patients treated with GM-CSF, while no serious adverse effects were observed in patients with G-CSF. These results suggest that G-CSF is preferable to GM-CSF in accelerating the recovery of neutrophils after allogeneic BMT.
Creator Keywords
G-CSF
GM-CSF
同種骨髄移植