A 66 year-old woman was admitted because of right hypochondralgia and high fever. Blood examination revealed leukocytosis and an elevation of tumor marker CA19-9. CT scanning and ultrasonography demonstrated a giant tumor in the anterior and median segment of the liver. The gallbladder was involved in the tumor. Celiac angiography showed an encasement on anterior branch and median branch of the hepatic artery, and the cystic artery was not demonstrated. These findings forced to plan extended right hepatectomy for an advanced cancer of the gallbladder. However, the tumor infiltrated in the duodenum and colon, and metastasized to the lymphonodes around the pancreas head. So extended right hepatectomy, pancreatoduodenectomy and partial resection of the colon were performed. The excised tumor was 11×8×5 cm in size. The patient was discharged on the 45th day after operation without any complication.