In orded to search for the influence of roughness on the vascular lesion from hydrodynamical point of view, the flow in a two-dimensional channel with several roughness elements was investigated numerically as a model of the blood flow in an artery with rough surface. Under the condition that the wall of vascular was rigid and the blood was assumed to be Newtonian fluid, the Navier-stokes equation was solved by the finite difference method for the range of Reynolds number of 50≦Re≦2000. From the calculation results, the influence of roughness on the vascular lesion was discussed about the acting shear stress and pressure on the rough wall which were considered as being a source of vascular lesion. A part of the present investigation has already been reported in the Journal of JSME (1986). In this paper, a reconsideration was made synthetically with the some additional data of the flow structure. In addition, an example of experimental result utilizing the flow-visualization technique by authers was also presented in this paper. Good agreement was obtained between the experimental and numerical results for the flow pattern over the rough wall.