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大学院医学系研究科（医学）

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Variation in heart rate variability between sitting and standing postures under different ambient temperatures
The bulletin of the Yamaguchi Medical School Volume 69 Issue 3-4 pp. 45 - 56
published_at 2022-12
Abstract Purpose: The purpose of this study was to investigate the effects of two different postures (sitting and standing) and three different ambient temperatures (10℃, 20℃, and 30℃) on heart rate variability (HRV) among healthy young adults. Methods: Twelve young adult volunteers (males 6, females 6) were recruited. Following acclimatization to any the room temperature (10℃, 20℃ or 30℃), 5-min measurements of HRV were conducted in sitting and standing postures of the subjects. Results: Compared to the sitting posture, measurements obtained in the standing posture revealed a significant decrease in high-frequency power/HF, root mean square of successive differences between RR intervals, standard deviation of Poincaré plot perpendicular to the line-of-identity or SD1 and SD1/standard deviation of Poincaré plot along the line-of-identity or SD2, and a significant increase in lowfrequency power/LF and LF/HF under all experimental conditions (p<0.05 to 0.005). Majority of HRV parameters showed significant differences while the values obtained under 10℃ were compared with 20℃ and 30℃ conditions, respectively (p<0.05 to 0.001). Conclusions: Our findings suggest the predominance of sympathetic tone in the standing compared with sitting posture. Furthermore, colder conditions caused a predominance of the parasympathetic activity in both sitting and standing postures, and such effects of ambient temperature on the sympathovagal balance were stronger in the latter posture.
Creators : Wada Sunao Mahbub MH Nakagami Yuki Hase Ryosuke Yamaguchi Natsu Takahashi Hidekazu Saito Hiroyuki Shimokawa Junki Watanabe Rie Harada Noriaki Tanabe Tsuyoshi Publishers : Yamaguchi University School of Medicine
Bartonella henselae DNA in seronegative patients with cat-scratch disease
山口医学 Volume 69 Issue 1 pp. 5 - 11
published_at 2020-02-28
Creators : Yanagihara Masashi Publishers : 山口大学医学会
Antioxidant, N-acetyl-L-cysteine inhibits the expression of the collagen α2 (I) promoter in the activated human hepatic stellate cell line in the absence as well as the presence of transforming growth factor-β
Hepatology research : the official journal of the Japan Society of Hepatology Volume 24 Issue 3 pp. 305 - 315
published_at 2002
Creators : Segawa Makoto Kayano Kozo Sakaguchi Eiki Okamoto Mariko Sakaida Isao Okita Kiwamu Publishers : Elsevier
Clinical outcomes of the GORE VIABAHN VBX balloonexpandable covered stent in aortoiliac occlusive disease and acute limb ischemia
The bulletin of the Yamaguchi Medical School Volume 69 Issue 3-4 pp. 27 - 35
published_at 2022-12
Abstract Objectives: This study examined the short-term outcomes of endovascular therapy (EVT) with the GORE VIABAHN VBX (VBX) which is a balloon-expandable covered stent in patients with aortoiliac occlusive disease (AIOD) and acute limb ischemia (ALI). Methods: This was a single-center retrospective review of patients with AIOD and ALI who underwent EVT with the VBX between December 2018 and January 2021. Primary, assisted, and secondary patency rates were assessed, along with 30-day mortality rates. Results: Twenty-two patients underwent EVT with the VBX; 18 patients had AIOD, whereas 4 had ALI. The incidence of TransAtlantic Intersociety Classification II D lesions was 50% (n=9). Technical success was 100%. One patient with unilateral common iliac artery stenosis developed an intraoperative dissection of the distal edge of the VBX, which required an additional self-expanding VIABAHN stent on the distal edge of the VBX. The primary patency rate at 24 months was 100%. No patients required additional target vessel treatment at a median follow-up of 10 months (range, 1-27). EVT was also successful in the four patients with ALI, who had no complications of the target vessel. Conclusion: The present study demonstrated that EVT with the VBX is effective for AIOD and ALI.
Creators : Mizoguchi Takahiro Morikage Noriyasu Ike Soichi Nagase Takashi Samura Makoto Harada Takasuke Kurazumi Hiroshi Suzuki Ryo Suehiro Kotaro Hamano Kimikazu Publishers : Yamaguchi University School of Medicine
Effectiveness of miglitol combined with various types of insulin therapy for reducing the daily glycemic fluctuation on Japanese type 2 diabetic patients : Evaluation with self-monitoring blood glucose (SMBG)
Therapeutic Research Volume 34 Issue 12 pp. 1503 - 1511
published_at 2013
Creators : Hirose Takahisa Watanabe Takahiro Watada Hirotaka Abiko Atsuko Haneda Masakazu Takebe Noriko Satoh Jo Yamaguchi Suguru Ishihara Hisamitsu Maeda Tomomi Eto Kazuhiro Ohta Akio Tanaka Yasushi Takeda Teiji Komatsu Mitsuhisa Ugi Satoshi Maegawa Hiroshi Ito Hiroyuki Noso Shinsuke Hiromine Yoshihisa Kawabata Yumiko Ikegami Hiroshi Terasaki Jungo Hanafusa Toshiaki Tominaga Takayuki Inoue Yasushi Tanizawa Yukio Matsumoto Toshio Kuroda Akio Matsuhisa Munehide Nomiyama Takashi Yanase Toshihiko Kobayashi Kunihisa Kondo Tatsuya Araki Eiichi Ishii Norio Igata Motoyuki Kukidome Daisuke Motoshima Hiroyuki Kawamori Ryuzo Publishers : Life Science Publishing
WNT7A regulates tumor growth and progression in ovarian cancer through the WNT/β-catenin pathway
Molecular cancer research : MCR Volume 10 Issue 3 pp. 469 - 482
published_at 2012-03
Creators : Yoshioka Shin King Mandy L. Ran Sophia Okuda Hiroshi MacLean II James A. McAsey Mary E. Sugino Norihiro Brard Laurent Watabe Kounosuke Hayashi Kanako Publishers : American Association for Cancer Research
In vivo activation of pro-form Bombyx cysteine protease (BCP) in silkmoth eggs : localization of yolk proteins and BCP, and acidification of yolk granules
Journal of insect physiology Volume 49 Issue 2 pp. 131 - 140
published_at 2003-02
Creators : Yamahana Y. Uto N. Tamotsu S. Miyata T. Yamamoto Y. Watabe S. Takahashi S.Y. Publishers : Elsevier
Multiple myeloma relapse in the irradiated liver : Involvement of hepatocyte growth factor akin to that after hepatocyte transplantation
Journal of radiotherapy in practice Volume 11 Issue 4 pp. 271 - 273
published_at 2012-12
Creators : Uetake Akiko Takeda Atsuya Shigematsu Naoyuki Ikeda Eiji Kametaka Minako Ohashi Toshio Kunieda Etsuo Publishers : Cambridge University Press
Pneumonia after esophageal surgery for squamous cell carcinoma : impact of HLA-DR antigen expression on monocytes
The bulletin of the Yamaguchi Medical School Volume 60 Issue 3-4 pp. 57 - 63
published_at 2013
Creators : Takemoto Yoshihiro Enoki Tadahiko Tanaka Yuuya Harada Eijirou Hamano Kimikazu Publishers : Yamaguchi University School of Medicine
An invited review following the Soujinkai Young Investigator Award : calreticulin is highly expressed in pancreatic cancer stem-like cells
The bulletin of the Yamaguchi Medical School Volume 67 Issue 3-4 pp. 19 - 23
published_at 2020
Creators : Matsukuma Satoshi Yoshimura Kiyoshi Tsunedomi Ryouichi Hazama Shoichi Nagano Hiroaki Publishers : Yamaguchi University School of Medicine
Enhanced diagnostic accuracy for quantitative bone scan using an artificial neural network system : A Japanese multi-center database project
EJNMMI Research Volume 3 Issue 1
published_at 2013
Creators : Nakajima Kenichi Nakajima Yasuo Horikoshi Hiroyuki Ueno Munehisa Wakabayashi Hiroshi Shiga Tohru Yoshimura Mana Ohtake Eiji Sugawara Yoshifumi Matsuyama Hideyasu Edenbrandt Lars Publishers : Springer
A case of endocrine cell carcinoma of the esophagus with gastric adenocarcinoma successfully treated by chemotherapy
山口医学 Volume 63 Issue 1 pp. 61 - 67
published_at 2014-02-01
Creators : Nagao Misato Okamoto Takeshi Nishimura Junnichi Nakamura Munetaka Goto Atsushi Nishikawa Jun Sakaida Isao Publishers : 山口大学医学会
A case of primary hepatic neuroendocrine carcinoma clinically suggested
山口医学 Volume 63 Issue 1 pp. 53 - 60
published_at 2014-02-01
Creators : Kawasato Ryo Shiratsuki Shogo Iwamoto Takuya Saeki Issei Urata Yohei Hidaka Isao Ishikawa Tsuyoshi Takami Taro Uchida Kouichi Terai Shuji Yamasaki Takahiro Sakaida Isao Publishers : 山口大学医学会
A case of temporary cardiac arrest during endscopic submucosal dissection for surperficial esophageal cancer with sick sinus syndrome
山口医学 Volume 63 Issue 1 pp. 37 - 42
published_at 2014-02-01
Creators : Aibe Yuki Yanai Hideo Hurutani Yuji Uchimoto Ryogo Hayashi Hiroto Murakami Tomoyuki Publishers : 山口大学医学会
A case of adenoid cystic carcinoma of the breast with the invasion to the skin
山口医学 Volume 63 Issue 1 pp. 43 - 47
published_at 2014-02-01
Creators : Harada Takasuke Orita Masahiko Hayashi Masanori Hirata Ken Morita Nobuyoshi Hoshii Yoshinobu Hamano Kimikazu Publishers : 山口大学医学会
The blood-nerve barrier breakdown and the diabetic neuropathy
山口医学 Volume 63 Issue 1 pp. 17 - 24
published_at 2014-02-01
Creators : Shimizu Fumitaka Publishers : 山口大学医学会
Impaired innate immune system and diseases
山口医学 Volume 63 Issue 1 pp. 5 - 10
published_at 2014-02-01
Creators : Tanabe Tsuyoshi Publishers : 山口大学医学会
Investigation of the factors of attendance and continuous to participate in dementia café among community-dwelling seniors
山口医学 Volume 70 Issue 2 pp. 71 - 81
published_at 2021-05-13
Creators : Fujimura Kazumi Hase Ryosuke Kijima Ayano Okochi Ayako Kumagai Tamaki Publishers : 山口大学医学会
Mucosa-associated lymphoid tissue (MALT) lymphoma arising in the esophagus, stomach, and lung
General thoracic and cardiovascular surgery Volume 59 Issue 12 pp. 826 - 830
published_at 2011-12
Creators : Hayashi Masataro Ueda Kazuhiro Tanaka Toshiki Enoki Tadahiko Tanaka Nobuyuki Gondo Toshikazu Hamano Kimikazu Publishers : Springer Japan
完全胸腔鏡下解剖学的肺切除術を安全に行うための工夫
日本外科学会雑誌 Volume 113 Issue 臨時増刊号2 pp. 174 - 174
published_at 2012-03-05
Creators : 田中 俊樹 上田 和弘 林 雅太郎 濱野 公一 Publishers : 日本外科学会
The development of a variable threshold analysis method to identify clones linked the clinicopathological features in an array-based CGH : its application to colorectal cancer
The bulletin of the Yamaguchi Medical School Volume 56 Issue 3-4 pp. 43 - 48
published_at 2009
Creators : Nakao Motonao Uchiyama Tetuji Adachi Jun Furuya Tomoko Oga Atsunori Kawauchi Shigeto Sasaki Kohsuke Publishers : Yamaguchi University School of Medicine
A case of raspberry-like foveolar-type gastric adenocarcinoma resected by strip biopsy
山口医学 Volume 70 Issue 1 pp. 53 - 58
published_at 2021-03-04
Creators : Fujimura Hiroyuki Nishikawa Jun Hamabe Koichi Izumiya Yuta Matsumoto Satoko Yoshitomi Shingo Ito Shunsuke Yamaoka Yuko Shirasawa Tomohiro Goto Atsushi Hashimoto Shinichi Okamoto Takeshi Hoshii Yoshinobu Sakaida Isao Publishers : 山口大学医学会
Nobiletin, a citrus flavonoid, suppresses SPC-induced abnormal vascular contraction
山口医学 Volume 70 Issue 1 pp. 29 - 35
published_at 2021-03-04
Creators : Miyanari Kenji Publishers : 山口大学医学会
A case report of gallbladder carcinoma with port site recurrence only in the muscle layer of abdominal wall
山口医学 Volume 62 Issue 4 pp. 229 - 233
published_at 2013-11-01
Creators : Amasaki Yotaro Kuga Takayuki Tanaka Yuya Oka Kazuhito Fujii Yasuhiro Yamaguchi Yuuki Mitani Nobuyuki Nagatomi Yuuji Hamano Kimikazu Publishers : 山口大学医学会
Four cases of ruptured abdominal aortic aneurysm treated by emergent endovascular aortic repair
山口医学 Volume 62 Issue 4 pp. 205 - 210
published_at 2013-11-01
Creators : Kawamura Daichi Nagase Takashi Samura Makoto Yamashita Osamu Murakami Masanori Suehiro Koutarou Morikage Noriyasu Hamano Kimikazu Publishers : 山口大学医学会
Practical approach for collection study of human biomaterials on intractable skin diseases
山口医学 Volume 62 Issue 4 pp. 199 - 204
published_at 2013-11-01
Creators : Muto Masahiko Publishers : 山口大学医学会
Cancer and microRNA as a diagnostic and therapeutic marker
山口医学 Volume 62 Issue 4 pp. 191 - 197
published_at 2013-11-01
Creators : Itoh Hiroshi Publishers : 山口大学医学会
Airway administration of vascular endothelial growth factor siRNAs induces transient airspace enlargement in mice
International journal of medical sciences Volume 10 Issue 12 pp. 1702 - 1714
published_at 2013-09-27
Creators : Takahashi Yusuke Izumi Yotaro Kohno Mitsutomo Ikeda Eiji Nomori Hiroaki Publishers : Ivyspring International
An invited review following the Soujinkai Award : ryanodine receptor bound calmodulin is essential to protect against catecholaminergic polymorphic ventricular tachycardia
Medical Science & Innovation Volume 70 Issue 1-2 pp. 1 - 6
published_at 2023-06
Catecholaminergic polymorphic ventricular tachycardia (CPVT) is caused by a single point mutation in the cardiac type 2 ryanodine receptor (RyR2). Using knock-in mouse (KI) model (R2474S/+), we previously reported that a single point mutation within the RyR2 sensitized the channel to agonists, primarily mediated by defective inter-domain interaction within the RyR2 and subsequent dissociation of calmodulin (CaM) from the RyR2. Here, we examined whether CPVT can be genetically rescued by enhancing the binding affinity of CaM to the RyR2. We first determined whether there was a possible amino-acid substitution within the CaM-binding domain in the RyR2 (3584-3603) that can enhance its binding affinity to CaM, and found that V3599K substitution showed the highest binding affinity of CaM to CaM-binding domain. Hence, we generated a heterozygous KI mouse model (V3599K/+) with a single amino acid substitution in the CaM-binding domain of the RyR2, and crossbred it with the heterozygous CPVT –associated R2474S/+ KI mouse to obtain a double heterozygous R2474S/V3599K KI mouse model. The CPVT phenotypes, bidirectional or polymorphic ventricular tachycardia, were inhibited in the R2474S/V3599K mice. Thus, enhancement of the CaM binding affinity of the RyR2 is essential to prevent CPVT-associated arrhythmogenesis.
Creators : Nakamura Yoshihide Yamamoto Takeshi Kobayashi Shigeki Yano Masafumi Publishers : Yamaguchi University School of Medicine
Dantrolene, a RyR2 stabilizer, restores impaired diastolic function in the pressure-verloaded hypertrophied heart
Medical Science & Innovation Volume 70 Issue 1-2 pp. 7 - 17
published_at 2023-06
To investigate whether dantrolene (DAN), cardiac ryanodine receptor (RyR2) stabilizer, improves impaired diastolic function in an early pressure-overloaded hypertrophied heart, pressure-overload hypertrophy was induced by transverse aortic constriction (TAC) in mice. Wild-type (WT) mice were divided into four groups: sham-operated mice (Sham), sham-operated mice treated with DAN (DAN+Sham), TAC mice (TAC), and TAC mice treated with DAN (DAN+TAC). The mice were then followed up for 2 weeks. Left ventricular (LV) hypertrophy was induced in TAC, but not DAN+TAC mice, 2 weeks after TAC. There were no differences in LV fractional shortening among the four groups. Catheter tip micromanometer showed that the time constant of LV pressure decay, an index of diastolic function, was significantly prolonged in TAC but not in DAN+TAC mice. Diastolic function was significantly impaired in TAC, but not in DAN+TAC mice as determined by cell shortening and Ca^{2+} transients. An increase in diastolic Ca^{2+} leakage and a decrease in calmodulin (CaM) binding affinity to RyR2 were observed in TAC mice, while diastolic Ca^{2+} leakage improved in DAN+TAC mice. Thus, DAN prevented the progression of hypertrophy and improved the impairment of LV relaxation by inhibiting diastolic Ca^{2+} leakage through RyR2 and the dissociation of CaM from RyR2.
Creators : Chang Yaowei Kobayashi Shigeki Yano Yasutake Uchida Tomoyuki Nawata Junya Fujii Shohei Nakamura Yoshihide Suetomi Takeshi Uchinoumi Hitoshi Oda Tetsuro Yamamoto Takeshi Yano Masafumi Publishers : Yamaguchi University School of Medicine
The factors of low-weight baby from mother had a normal BMI before pregnancy : Comparison between the mature and the low-birth weight baby groups
Maternal health Volume 54 Issue 1 pp. 156 - 163
published_at 2013-04
Creators : 金下 幸子 重永 美香 下ノ村 育代 藤岡 奈美 Publishers : 日本母性衛生学会
Effects of interportal error on dose distribution in patients undergoing breath-holding intensity-modulated radiotherapy for pancreatic cancer : evaluation of a new treatment planning method
Journal of Applied Clinical Medical Physics Volume 14 Issue 5 pp. 43 - 51
published_at 2013
Creators : Takakura Toru Nakamura Mitsuhiko Shibuya Keiko Nakata Manabu Nakamura Akira Matsuo Yukinori Shiinoki Takeshi Higashimura Kyoji Teshima Teruki Hiraoka Masahiro Publishers : American College of Medical Physics
Regulation of immune stroma cells by modulating lipid metabolism
山口医学 Volume 65 Issue 1 pp. 23 - 29
published_at 2016-02-01
Creators : Tokuda Nobuko Publishers : 山口大学医学会
The Asian project for collaborative derivation of reference intervals: (2) results of non-standardized analytes and transference of reference intervals to the participating laboratories on the basis of cross-comparison of test results
Clinical chemistry and laboratory medicine Volume 51 Issue 7 pp. 1443 - 1457
published_at 2013-07
Creators : Ichihara Kiyoshi Ceriotti Ferruccio Kazuo Mori Huang Yang-Yang Shimizu Yoshihisa Suzuki Haruki Kitagawa Masami Yamauchi Kazuyoshi Hayashi Sadao Tsou Chia-Chun Yamamoto Yoshikazu Ishida Shigeo Leong Linda Sano MIchitaka Lim Hwan Sub Suwabe Akira Woo Hee-Yeon Kojima Keiya Okubo Yoshio Publishers : Walter de Gruyter
Report on the activities of the doctor helicopter in yamaguchi prefecture along the great east-japan earthquake
山口医学 Volume 62 Issue 3 pp. 137 - 141
published_at 2013-08-01
Creators : Kasaoka Shunji Todani Masaki Tanaka Ryo Miyauchi Takashi Kaneda Koutaro Kawamura Yoshikatsu Oda Yasutaka Tsuruta Ryosuke Publishers : 山口大学医学会
UDP-glucuronosyltransferase (UGT) 1A1*28 Polymorphism-directed Phase II Study of Irinotecan with 5'-deoxy-5-fluorouridine (5'-DFUR) for Metastatic Colorectal Cancer
Anticancer research Volume 33 Issue 8 pp. 3423 - 3430
published_at 2013-08
Creators : Kandkiyo Shinsuke Hazama Shoichi Kondo Hiroshi Nagashima Atsushi Eto Ryuichi Yoshida Shin Shimizu Ryoichi Araki Atsuhiro Yamamoto Tatsuhito Uchiyama Tetsuji Yoshino Shigefumi Okayama Naoko Hinoda Yuji Oka Masaaki Publishers : Potamitis Press
T1/high-grade膀胱癌に対するsecond TURの検討と予後予測の試み
The Nishinihon journal of urology Volume 75 Issue 6 pp. 311 - 317
published_at 2013-06
Creators : 原 貴彦 小林 圭太 西嶋 淳 川井 禎久 松本 洋明 長尾 一公 坂野 滋 松山 豪泰 Publishers : 日本泌尿器科学会西日本連合地方会
Significance of ultrasound examination of skin and subcutaneous tissue in secondary lower extremity lymphedema
AVD : annals of vascular diseases : the official journal of Japanese College of Angiology, the Japanese Society for Vascular Surgery, Japanese Society of Phlebology Volume 6 Issue 2 pp. 180 - 188
published_at 2013
Creators : Suehiro Kotaro Morikage Noriyasu Murakami Masanori Yamashita Osamu Samura Makoto Hamano Kimikazu Publishers : Medical Tribune
Genome-wide DNA methylation analysis reveals a potential mechanism for the pathogenesis and development of uterine leiomyomas
PloS one Volume 8 Issue 6 pp. e66632 -
published_at 2013-06
Creators : Maekawa Ryo Sato Shun Yamagata Yoshiaki Asada Hiromi Tamura Isao Lee Lifa Okada Maki Tamura Hiroshi Takaki Eiichi Nakai Akira Sugino Norihiro Publishers : Public Library of Science
Utility of a panel of sera for the alignment of test results in the worldwide multicenter study on reference values
Clinical chemistry and laboratory medicine Volume 51 Issue 5 pp. 1007 - 1025
published_at 2013-05
Creators : Ichihara Kiyoshi Ozarda Yesim Klee George Straseski Joely Baumann Nikola Ishikura Kiyohide Publishers : Walter de Gruyter
Rationale, design and baseline characteristics of a study to evaluate effects of candesartan on cardiovascular events after drug-eluting stent implantation in patients with ischemic heart disease
Journal of atherosclerosis and thrombosis Volume 20 Issue 5 pp. 472 - 480
published_at 2013
Creators : Sakamoto Tomohiro Ogawa Hisao Nakao Koichi Koide Shunichi Yamamoto Nobuyasu Shimomura Hideki Matsumura Toshiyuki Oshima Shuichi Kikuta Koichi Oka Hideki Kimura Kazuo Matsui Kunihiko Publishers : Japan Atherosclerosis Society
A case-control study of bronchiolitis obliterans syndrome following allogeneic hematopoietic stem cell transplantation
Transplant international : official journal of the European Society for Organ Transplantation Volume 26 Issue 6 pp. 631 - 639
published_at 2013-06
Creators : Nakasone Hideki Kanda Junya Yano Shingo Atsuta Yoshiko Ago Hiroatsu Fukuda Takahiro Kakihana Kazuhiko Adachi Tatsuya Yujiri Toshiaki Taniguchi Shuichi Taguchi Jun Morishima Yasuo Nagamura Tokiko Sakamaki Hisashi Mori Takehiko Murata Makoto Publishers : Springer International
Simultaneous analysis of multiple cytokines in the vitreous of patients with sarcoid uveitis
Investigative ophthalmology & visual science : journal of clinical and basic research Volume 53 Issue 7 pp. 3827 - 3833
published_at 2012-06
Creators : Nagata Kenji Maruyama Kazuichi Uno Kazuko Shinomiya Katsuhiko Yoneda Kazuhito Hamuro Junji Sugita Sunao Yoshimura Takeru Sonoda Koh-Hei Mochizuki Manabu Kinoshita Shigeru Publishers : C.V. Mosby
Outcomes of endoscopic submucosal dissection for early gastric cancer and factors associated with incomplete resection
Hepato-Gastroenterology : journal of clinical research and practice Volume 60 Issue 121 pp. 46 - 53
published_at 2013-03
Creators : Goto Atsushi Nishikawa Jun Okamoto Takeshi Hamabe Kouichi Nishimura Junnichi Nakamura Munetaka Kiyotoki Shu Saito Mari Miura Osamu Sakaida Isao Publishers : Georg Thieme
Utility of computed tomographic enteroclysis/enterography for the assessment of mucosal healing in Crohn's disease
Gastroenterology research and practice Volume 2013 pp. 984916 -
published_at 2013
Creators : Hashimoto Shinichi Shimizu Kensaku Shibata Hiroaki Kanayama Satoko Tanabe Ryo Onoda Hideko Matsunaga Naohumi Sakaida Isao Publishers : Hindawi Publishing
Age-dependent clinical and genetic characteristics in Japanese patients with arrhythmogenic right ventricular cardiomyopathy/dysplasia
Circulation journal : official journal of the Japanese Circulation Society Volume 77 Issue 6 pp. 1534 - 1542
published_at 2013
Creators : Ohno Seiko Nagaoka Iori Fukuyama Megumi Kimura Hiromi Itoh Hideki Makiyama Takeru Shimizu Akihiko Horie Minoru Publishers : Japanese Circulation Society
Brain microvascular accumulation and distribution of the NOTCH3 ectodomain and granular osmiophilic material in CADASIL
Journal of neuropathology and experimental neurology Volume 72 Issue 5 pp. 416 - 431
published_at 2013-03-01
Creators : Yamamoto Yumi Craggs Lucinda J. L. Watanabe Atsushi Booth Trevor Attems Johannes Low Roger W. C. Oakley Arthur E. Kalaria Raj N. Publishers : Waverly Press | American Association of Neuropathologists
オピオイドを取り巻く新しい話題 : A.オピオイドとは何か : 2.下行性抑制系とオピオイド
The Journal of pain clinic Volume 33 Issue 4 pp. 239 - 249
published_at 2012-10
Creators : Ishikawa Toshizo Publishers : あゆむ出版
Late-onset primary intestinal lymphangiectasia successfully managed with octreotide : a case report
AVD : annals of vascular diseases : the official journal of Japanese College of Angiology, the Japanese Society for Vascular Surgery, Japanese Society of Phlebology Volume 5 Issue 1 pp. 96 - 99
published_at 2012
Creators : Suehiro Kotaro Morikage Noriyasu Murakami Masanori Yamashita Osamu Hamano Kimikazu Publishers : Japanese College of Angiology | The Japanese Society for Vascular Surgery | Japanese Society of Phlebology
Paroxysmal sympathetic hyperactivity after traumatic brain injury experienced in Yamaguchi University
山口医学 Volume 70 Issue 1 pp. 37 - 43
published_at 2021-03-04
Creators : Fujiyama Yuichi Publishers : 山口大学医学会
The different effects of acacetin and biochanin A on abnormal contraction of vascular smooth muscle
山口医学 Volume 70 Issue 1 pp. 45 - 52
published_at 2021-03-04
Creators : Zhang Min Publishers : 山口大学医学会
Indication of augumentation and iIleocystoplasty for colorectal cancer with infiltration of the urinary bladder
山口医学 Volume 62 Issue 2 pp. 99 - 103
published_at 2013-05-01
Creators : Uesugi Naomasa Katoh Tomoe Yoshida Kumiko Onoda Masahiko Katsuki Takefumi Furutani Akira Kawano Kazuaki Enoki Tadahiko Hamano Kimikazu Publishers : 山口大学医学会
糖尿病モデルマウスTSODにおける加齢と聴覚について
Audiology Japan Volume 54 Issue 5 pp. 609 - 610
published_at 2011-09-30
Creators : Tsuda Junko 菅原 一真 金川 英寿 御厨 剛史 山下 裕司 Publishers : 日本オージオロジー学会
An invited review following the Soujinkai Award : development of novel chimeric antigen receptor-expressing t cells promoting immune cell infiltration and survival in the tumor tissue
The bulletin of the Yamaguchi Medical School Volume 67 Issue 3-4 pp. 11 - 17
published_at 2020
Creators : Adachi Keishi Tamada Koji Publishers : Yamaguchi University School of Medicine
MIG and I309 accelerates proliferation of human bone marrow-derived mesenchymal stem cells
The bulletin of the Yamaguchi Medical School Volume 67 Issue 1-2 pp. 1 - 10
published_at 2020
Creators : Aibe Yuki Takami Taro Fujisawa Koichi Matsumoto Toshihiko Sakaida Isao Publishers : Yamaguchi University School of Medicine
Current status of rifaximin treatment for hepatic encephalopathy at our hospital
山口医学 Volume 69 Issue 2 pp. 75 - 80
published_at 2020-05-01
Creators : Iwamoto Takuya Sakaida Isao Publishers : 山口大学医学会
Superoxide stimulation enhances CXCR4 expression in heart muscle-derived stem cells via ASK1 activation
The bulletin of the Yamaguchi Medical School Volume 60 Issue 1-2 pp. 11 - 18
published_at 2013
Creators : Akashi Shintaro Miura Toshiro Shibuya Masaki Fukagawa Yasuhiro Oda Takamasa Nakamura Takeshi Ikeda Yasuhiro Matsuzaki Masunori Yano Masafumi Publishers : Yamaguchi University School of Medicine
Sarcomere gene mutations are associated with increased cardiovascular events in left ventricular hypertrophy : Results from multicenter registration in Japan
JACC: Heart Failure Volume 1 Issue 6 pp. 459 - 466
published_at 2013-12
Creators : Fujita Takashi Fujino Noboru Anan Ryuichiro Tei Chuwa Kubo Toru Doi Yoshinori Kinugawa Shintaro Tsutsui Hiroyuki Kobayashi Shigeki Yano Masafumi Asakura Masanori Kitakaze Masafumi Komuro Issei Konno Tetsuo Hayashi Kenshi Kawashiri Masaaki Ino Hidekazu Yamagishi Masakazu Publishers : Elsevier
Sequel of jailed side branch : Four years after implantation with a sirolimus-eluting stent
Circulation Journal Volume 78 Issue 3 pp. 772 - 774
published_at 2013
Creators : Tateishi Hiroki Okamura Takayuki Yamada Jutaro Nao Tomoko Maeda Takao Oda Takamasa Nakamura Takeshi Miura Toshiro Matsuzaki Masunori Yano Masafumi Publishers : Japanese Circulation Society
A low-dose β1-blocker effectively and safely slows the heart rate in patients with acute decompensated heart failure and rapid atrial fibrillation
Cardiology (Switzerland) Volume 127 Issue 2 pp. 105 - 113
published_at 2014-01
Creators : Kobayashi Shigeki Murakami Wakako Myoren Takeki Tateishi Hiroki Okuda Shinichi Doi Masahiro Nao Tomoko Wada Yasuaki Matsuzaki Masunori Yano Masafumi Publishers : Karger
An invited review following the Soujinkai Fujiu Memorial Award : elucidation of drug resistance mechanisms in prostate cancer: overcome them by investigating bench to bedside
The bulletin of the Yamaguchi Medical School Volume 69 Issue 1-2 pp. 1 - 9
published_at 2022-06
Androgen receptor (AR)-signaling plays an important role in promoting tumor cell survival and the development of castration-resistant prostate cancer (CRPC). Androgen deprivation therapy is the basic therapeutic strategy for AR signaling blockade, but that effects wonʼt last long and most of metastatic prostate cancer show castration resistance. Recently, new agents, AR Axis Targeted agents (ARAT), have been developed. We have been developing our bench-to-bedside translational research to elucidate the mechanisms of drug resistance in prostate cancer. This review describes our investigational results and recent advances in CRPC with ARAT treatment strategy.
Creators : Matsumoto Hiroaki Matsuyama Hideyasu Publishers : Yamaguchi University School of Medicine
A novel mutation in IKBKG gene in a female child with incontinentia pigmenti
The bulletin of the Yamaguchi Medical School Volume 69 Issue 1-2 pp. 21 - 25
published_at 2022-06
Incontinentia pigmenti (IP; OMIM# 308300) is a rare inherited disease caused by a mutation of IKBKG, which is also known as NEMO, located on Xq28. IP patients usually present with abnormalities of skin, eyes, nails and central nervous system. The neurological damege, which occur usually from neonatal through the early infantile period, leads to neulogical complication such as development retardation, motor paralysis and epilepsy. However, there has been little study done concerning the effect of therapy for the neural abnormalities. We have investigated the clinical findings in a female IP case with a novel mutation of IKBKG for six years due to disclosing the neurological prognosis and the immunological features. It is hoped that the present study will contribute to a better management of IP patients.
Creators : Sakata Yasufumi Hirano Reiji Yasudo Hiroki Shimomura Yutaka Takada Hidetoshi Suehiro Yutaka Ohga Shouichi Hasegawa Shunji Publishers : Yamaguchi University School of Medicine
Experience-specific plasticity at excitatory and inhibitory synapses onto granule cells in the dentate gyrus
The bulletin of the Yamaguchi Medical School Volume 69 Issue 1-2 pp. 11 - 19
published_at 2022-06
The hippocampal dentate gyrus has been identified to play a critical role in maintaining contextual memory in many mammalian species. To evaluate learninginduced synaptic plasticity of granule cells, we subjected male rats to an inhibitory avoidance (IA) task and prepared acute hippocampal slices. In the presence of 0.5 μM tetrodotoxin, we recorded miniature excitatory post synaptic currents (mEPSCs) and inhibitory post synaptic currents (mIPSCs) in male rats experiencing four groups: untrained, IA-trained, unpaired, and walk-through. Compared with the untrained, IA-trained, unpaired, and walk-through groups, the unpaired group significantly enhanced mean mEPSC amplitudes, suggesting the experience-induced plasticity at AMPA receptor-mediated excitatory synapses. For inhibitory synapses, both unpaired and walk-through groups significantly decreased mean mIPSC amplitudes, showing the experience-induced reduction of postsynaptic GABAA receptor-mediated currents. Unlike the plasticity at CA1 synapses, it was difficult to explain the learning- specific plasticity at the synapses. However, overall multivariate analysis using four variables of mE(I)PSC responses revealed experience-specific changes in the diversity, suggesting that the diversity of excitatory/inhibitory synapses onto granule cells differs among the past experience of animals include the learning. In comparison with CA1 pyramidal neurons, granule cells consistently showed greater amplitude and frequency of mE(I)PSCs. Fluctuation analysis further revealed that granule cells provide more postsynaptic AMPA receptor channels and greater single-channel current of GABAA receptors of than CA1 pyramidal neurons. These findings show functional differences between two types of principal cells in the hippocampus.
Creators : Han Thiri Zin Sakimoto Yuya Mitsushima Dai Publishers : Yamaguchi University School of Medicine
Echocardiographic features of acute-phase microscopic polyangiitis in Japanese patients : a single-centre retrospective study
背景：顕微鏡的多発血管炎 (MPA) は全身臓器が障害される疾患である。しかしながら、MPA患者における心臓超音波検査（心エコー図検査）における指標の特徴については不明な点が多い。 目的：本研究は、単施設後ろ向き研究で、ステロイド療法の新規導入または再導入後2週間以内に心エコーを行ったMPA患者15名を対象とし、その心エコー所見の特徴について検討することを研究の目的とした。30人の年齢・性別をマッチさせた心疾患のないコントロール群と比較検討した。 方法と結果：左室径、左室駆出率、拡張早期僧帽弁輪最大移動速度 (e’) に2群間で有意差は認めなかった。一方、MPA群では左房径、左房容積係数が有意に高く、左室流入血流速波形 (TMF) の早期拡張期充満速度(E波)と肺静脈流入拡張期血流速度 (D波) の高さ、三尖弁における収縮期右室-右房最大圧較差も有意に高く、TMFのE波の減速時間 (DCT) は短縮していた。血清CRPはTMFのE波高、E/A比およびDCTと相関が見られた。今回の研究では、MPA患者におけるe’の有意な低下がみられなかったことから、左室弛緩能の低下よりはむしろ左室スティフネスの上昇によって左室拡張機能低下が生じ、結果として左房拡大が生じている可能性が示唆された。 結語：急性期MPA患者では左室拡張機能低下によると考えられる左房拡大を生じていた。MPA患者、特に強い炎症反応を伴う患者では、心機能評価を行うことが重要であることが示唆された。
Creators : 木下 奈津
Time in stress and depression
Time studies Volume 3 pp. 11 - 14
published_at 2009-03-31
Creators : Nakamura Shouji Publishers : 山口大学時間学研究所
The validation of a no-drain policy after thoracoscopic major lung resection
山口医学 Volume 68 Issue 4 pp. 119 - 126
published_at 2019-12-11
Creators : Murakami Junichi Publishers : 山口大学医学会
Immunohistochemical examination of Aκ amyloidosis with antibody against adjacent portion of the carboxy terminus of immunoglobulin kappa light chain
Medical molecular morphology : official journal of the Japanese Society for Clinical Molecular Morphology Volume 45 Issue 3 pp. 124 - 128
published_at 2012
Creators : Hoshii Yoshinobu Nanbara Hidemi Cui Dan Takahashi Mutsuo Ikeda Eiji Publishers : Springer
Identification of differentially expressed proteins in tumour necrosis factor-alpha-resistant and -sensitive rat hepatoma cells
Anticancer research Volume 31 Issue 6 pp. 2059 - 2063
published_at 2011-06
Creators : Kuramitsu Yasuhiro Zhang Xiulian Wang Yufeng Nakamura Kazuyuki Publishers : Potamitis Press
Combined use of free vascularized bone graft and extracorporeally-irradiated autograft for reconstruction of massive bone and joint defects after resection of malognant tumor
Orthopedics & Traumatology Volume 61 Issue 2 pp. 186 - 191
published_at 2012-03-25
Creators : Iwanaga Ryuta Muramatsu Keiichi Taguchi Toshihiko Ihara Koichiro Publishers : 西日本整形・災害外科学会
Hsp90 prevents interaction between CHIP and HERG proteins to facilitate maturation of wild-type and mutant HERG proteins
Cardiovascular Research Volume 100 Issue 3 pp. 520 - 528
published_at 2013-12-01
Creators : Iwai Chisato Li Peili Kurata Yasutaka Hoshikawa Yoshiko Morikawa Kumi Maharani Nani Higaki Katsumi Sasano Tetsuro Notsu Tomomi Ishido Yuko Miake Junichiro Yamamoto Yasutaka Shirayoshi Yasuaki Ninomiya Haruaki Nakai Akira Murata Shigeo Yoshida Akio Yamamoto Kazuhiro Hiraoka Masayasu Hisatome Ichiro Publishers : British Medical Association | Elsevier Science
Forensic pharmacokinetics of alcohol and its metabolites for the purpose of expert witness testimony
法医学の実際と研究 Volume 61 pp. 1 - 24
published_at 2018
Creators : Fujimiya Tatsuya Publishers : 法医学談話会
Changes of student’s questionnaire evaluation after practice with expanded clinical clerkship
山口医学 Volume 68 Issue 2-3 pp. 75 - 80
published_at 2019-08-09
Creators : Hisanaga Takuro Katsura Shunsaku Nishimoto Arata Fujimiya Tatsuya Shirasawa Bungo Publishers : 山口大学医学会
Rapid and sensitive detection of UGT1A1 polymorphisms associated with irinotecan toxicity by a novel DNA microarray
山口医学 Volume 69 Issue 4 pp. 161 - 168
published_at 2020-12-25
Creators : Tsunedomi Ryouichi Publishers : 山口大学医学会
Severity and patterns of blood-nerve barrier breakdown in patients with chronic inflammatory demyelinating polyradiculoneuropathy: Correlations with Clinical subtypes
PloS one Volume 9 Issue 8 pp. e104205 -
published_at 2014-08-08
Creators : Shimizu Fumitaka Sawai Setsu Sano Yasuteru Beppu Minako Misawa Sonoko Nishihara Hideaki Koga Michiaki Kuwabara Satoshi Kanda Takashi Publishers : Public Library of Science
Efficacy of methylprednisolone pulse therapy for acute relapse in Japanese patients with multiple sclerosis and neuromyelitis optica : A multicenter retrospective analysis – 1. Whole group analysis
Clinical and Experimental Neuroimmunology Volume 4 Issue 3 pp. 305 - 317
published_at 2013-12
Creators : Kira Jun-ichi Yamasaki Ryo Yoshimura Satoshi Fukazawa Toshiyuki Yokoyama Kazumasa Fujihara Kazuo Ogino Mieko Yokota Takanori Miyamoto Katsuichi Niino Masaaki Nomura Kyoichi Tomioka Ryo Tanaka Masami Kawachi Izumi Ohashi Takashi Kaida Kenichi Matsui Makoto Nakatsuji Yuji Ochi Hirofumi Fukaura Hikoaki Kanda Takashi Nagaishi Akiko Togo Kanae Mizusawa Hidehiro Kawano Yuji Publishers : Wiley-Blackwell
The Asian project for collaborative derivation of reference intervals: (1) strategy and major results of standardized analytes
Clinical chemistry and laboratory medicine Volume 51 Issue 7 pp. 1429 - 1442
published_at 2013-07
Creators : Ichihara Kiyoshi Ceriotti Ferruccio Tam Tran Huu Sueyoshi Shigeo Poon Priscilla M.K. Thong Mee Ling Higashiuesato Yasushi Wang Xuejing Kataoka Hiromi Matsubara Akemi Shiesh Shu-Chu Muliaty Dewi Kim Jeong-Ho Watanabe Masakazu Lam Christopher W.K. Siekmann Lothar Lopez Joseph B.Lopez Panteghini Mauro Publishers : Walter de Gruyter
Diagnosis system for predicting the centrosome hyperamplification in bladder cancer by using DNA microarray data
Journal of advanced computational intelligence and intelligent informatics Volume 17 Issue 2 pp. 244 - 251
published_at 2013-03
Creators : Tokunaga Kazuhiro Kubosaka Fumiya Suetake Noriaki Uchino Eiji Matsuyama Hideyasu Publishers : Fuji Technology Press
血管再生療法の治療効果を増強する低酸素プレコンディショニングは加齢動物の骨髄細胞に対しても有効か?
日本外科学会雑誌 Volume 113 Issue 臨時増刊号2 pp. 391 - 391
published_at 2012-03-05
Creators : 藏澄 宏之 久保 正幸 森景 則保 美甘 章仁 李 桃生 濱野 公一 Publishers : 日本外科学会
Overexpression of runt-related transcription factor-1 at invasive front in oral squamous cell carcinoma is associated with lymph node metastasis and poor prognosis
The bulletin of the Yamaguchi Medical School Volume 66 Issue 1-2 pp. 15 - 27
published_at 2019
Creators : Hisano Takahiro Cui Dan Harada Koji Kimura Tokuhiro Mishima Katsuaki Ikeda Eiji Publishers : Yamaguchi University School of Medicine
Intraoperative anaphylactic shock related to fibrin glue application during video-assisted thoracoscopic surgery
山口医学 Volume 69 Issue 3 pp. 141 - 144
published_at 2020-09-25
Creators : Yano Yuka Kuga Takayuki Sakamoto Ryuunosuke Shigeta Masatoshi Iida Yasuhiko Publishers : 山口大学医学会
Utility of contrast-enhanced ultrasonography for the evaluation of partial splenic embolization
The bulletin of the Yamaguchi Medical School Volume 66 Issue 1-2 pp. 7 - 13
published_at 2019
Creators : Fukui Yumi Saeki Issei Matsuda Takashi Maeda Masaki Hisanaga Takuro Iwamoto Takuya Matsumoto Toshihiko Hidaka Isao Ishikawa Tsuyoshi Takami Taro Yamasaki Takahiro Sakaida Isao Publishers : Yamaguchi University School of Medicine
Influence of aging on the quantity and quality of human cardiac stem cells
山口医学 Volume 68 Issue 1 pp. 13 - 22
published_at 2019-03-01
Creators : Nakamura Tamami Publishers : 山口大学医学会
Glucose-regulated protein 78 autoantibody associates with blood-brain barrier disruption in neuromyelitis optica
山口医学 Volume 68 Issue 1 pp. 23 - 29
published_at 2019-03-01
Creators : Shimizu Fumitaka Publishers : 山口大学医学会
Importance of cancer screening check-up encouragement to senior citizens after retirement : Based on analysis of Yamaguchi Prefecture cancer registration 2008-2014
山口医学 Volume 68 Issue 1 pp. 31 - 37
published_at 2019-03-01
Creators : Sunagawa Hiroshi Publishers : 山口大学医学会
ペースメーカー患者の心不全入院における心室ペーシング比率やQRS幅の影響について
Therapeutic research Volume 33 Issue 9 pp. 1348 - 1349
published_at 2012-09-20
Creators : 板垣 　和夫 瀧田 覚 関 耕三郎 佐々木 徹 清水 昭彦 Matsuzaki Masanori Publishers : Life Science Publishing
An invited review following the Soujinkai Fujiu Memorial Award : development of stent-enhanced 3d optical coherence tomography and its clinical application for coronary bifurcation lesions
The bulletin of the Yamaguchi Medical School Volume 68 Issue 1-2 pp. 5 - 10
published_at 2021
Creators : Okamura Takayuki Yano Masafumi Publishers : Yamaguchi University School of Medicine
Elucidation of proliferative capability of mononuclear tetraploid cells, emerging spontaneously from diploid cells, using image cytometry and fluorescence in situ hybridization
Cell proliferation Volume 46 Issue 3 pp. 356 - 63
published_at 2013-06
Creators : Ito Hideaki Oga Atsunori Furuya Tomoko Ikemoto Kenzo Amakawa Genta Chochi Yasuyo Kawauchi Shigeto Sasaki Kohsuke Publishers : Published for the Cell Kinetics Society, the European Study Group for Cell Proliferation and the International Cell Cycle Society by Blackwell Scientific Publications
Currents status and prospects of autologous bone marrow cell infusion therapy for liver cirrhosis patients
The bulletin of the Yamaguchi Medical School Volume 56 Issue 1-2 pp. 1 - 3
published_at 2009
Creators : Terai Shuji Publishers : Yamaguchi University School of Medicine
高解像度マルチディスプレイシステムを用いた理科教育の考案 : 理科教育におけるメダカや動物コンテンツ活用のための新ツール
日本理科教育学会全国大会要項 Volume 62 pp. 360 - 360
published_at 2012-08-11
Creators : Oga Atsunori Ikemoto Kenzo Ueno Tomio Oda Shoji Sasaki Kohsuke Publishers : 日本理科教育学会
Microbial contamination of in-use ophthalmic preparations and its prevention
The bulletin of the Yamaguchi Medical School Volume 63 Issue 1-2 pp. 17 - 24
published_at 2016
Aims: To clarify the usefulness of preservative-free ophthalmic preparations equipped with a filter. Methods: A total of 1,615 samples of in-use ophthalmic preparations were examined for microbial contamination. Results: Of 1,094 samples of preservative-containing ophthalmic preparations, 31 (2.8%) showed microbial contamination. Of 289 samples of preservative-free ophthalmic preparations without a filter, 6 (2.1%) were contaminated, consisting of 4 (13.8%) of 29 samples of hospital preparations and 2 (0.8%) of 260 samples of commercially available new quinolone antimicrobial agents. On the other hand, the microbial contamination rate in preservative-free ophthalmic preparations equipped with a filter was 0% (0 of 232 samples).The major contaminants detected in these preservative-containing ophthalmic preparations and preservative-free ophthalmic preparations without a filter were glucose-nonfermentative Gram-negative bacilli such as Pseudomonas fluorescens, Acinetobacter spp., and P. aeruginosa, coagulase (-) staphylococci, and Candida spp. The contaminant level was 10-99 colony forming units (CFU)/mL in 37.8% (14 of 37 samples), and 10^2 - 10^6 CFU/mL in 62.2% (23 of 37 samples). Conclusions: Preservative-free ophthalmic preparations equipped with a filter not only have zero risk of the oculotoxic effects of preservatives, but are also safe in terms of their lack of microbial contamination.
Creators : Saisyo Atsuyuki Oie Shigeharu Kimura Kazuhiro Sonoda Koh-Hei Furukawa Hiroyuki Publishers : Yamaguchi University School of Medicine
Immunoglobulin-resistant kawasaki disease associated with human parvovirus B19 infection
The bulletin of the Yamaguchi Medical School Volume 65 Issue 1-2 pp. 21 - 25
published_at 2018
Creators : Iida Yasunori Hasegawa Shunji Korenaga Yuno Okada Seigo Suzuki Yasuo Hirano Reiji Ohga Shouichi Publishers : Yamaguchi University School of Medicine
Effect of low-grade exercise on echocardiographic indexes in healthy young adults
The bulletin of the Yamaguchi Medical School Volume 65 Issue 1-2 pp. 1 - 10
published_at 2018
Creators : Yoshida Hirokazu Tanaka Nobuaki Toyota Ayako Kunimitsu Kenta Wada Yasuaki Fujii Ayano Ariyoshi Toru Okuda Shinichi Yano Masafumi Publishers : Yamaguchi University School of Medicine
Assessment of the doctor car system in Ube City, and its effect to cardiopulmonary arrest
Journal of Japanese Society for Emergency Medicine Volume 15 Issue 3 pp. 387 - 392
published_at 2012-06
Creators : Kaneda Kotaro Hosomoto Kakeru Miyauchi Takashi Kawamura Yoshikatsu Oda Yasutaka Kasaoka Shunji Tsuruta Ryosuke Publishers : 日本臨床救急医学会
副伝導路が高周波カテーテルアブレーションによりdormant conductionとなりincessant form型の房室回帰性頻拍で再発した潜在性WPW症候群の1例
心臓 Volume 44 Issue 3 pp. 88 - 95
published_at 2012-12-30
Creators : 上山 剛 吉賀 康裕 土井 正浩 吉田 雅昭 平塚 淳史 Fukuda Masakazu 加藤 孝佳 文本 朋子 Matsuzaki Masanori 清水 昭彦 Publishers : 医事通信社
メダカの全身組織ブラウジングシステム : 理科教育におけるメダカ活用のための新ツール
日本理科教育学会全国大会要項 Volume 62 pp. 214 - 214
published_at 2012-08-11
Creators : Oda Shoji Oota Hiroki Nishimaki Toshiyuki Katsumura Takafumi Oga Atsunori Sasaki Kohsuke Taniguchi Yoshihito Kimori Yoshitaka Kamei Yasuhiro Publishers : 日本理科教育学会
Effects of tolvaptan on volume overload in Japanese patients with heart failure : Results of a phase II, multicenter, randomized, double-blind, placebo-controlled, parallel-group study
Cardiovascular drugs and therapy Volume 25 Issue Supplement 1 pp. 19 - 31
published_at 2011-12
Creators : Matsuzaki Masanori Hori Masatsugu Izumi Tohru Asanoi Hidetsugu Tsutamoto Takayoshi Publishers : Nijhoff
Liquid biopsy test based on a sensitive dna methylation assay for diagnosing hepatocellular carcinoma : which is a better marker, methylated sst or sept9?
山口医学 Volume 70 Issue 3 pp. 89 - 98
published_at 2021-09-01
We performed this study to investigate whether serum cell-free DNA testing(liquid biopsy)of either methylated SEPT9 or methylated SST, which are possible biomarkers of HCC, in combination with AFP may improve clinical performance for the detection of HCC. Study subjects included 25 healthy controls, 15 patients with chronic liver disease without HCC, and 38 patients with HCC. Methylation level of serum cell-free SEPT9 and SST was measured by methylation-sensitive restriction enzymes followed by multiplex droplet digital polymerase chain reaction. According to receiver operating characteristic curve analysis to discriminate between non-HCC group(including control group and chronic liver disease without HCC group)and HCC group, area under the curve(AUC)was 0.73 by AFP and 0.73 by mSEPT9, whereas it was only 0.59 by mSST. Regarding combination tests, although negative predictive values were almost same between the AFP + mSEPT9 test and the AFP + mSST test(75.0% vs 72.2%),a positive predictive value of AFP + mSEPT9 test was higher than that of the AFP + mSST test(79.4% vs. 66.7%).In conclusions, methylated SEPT9 was a better companion marker of AFP for HCC screening than methylated SST.
Creators : Yamasaki Ayano Suehiro Yutaka Hoshida Tomomi Saeki Issei Yamauchi Kotoh Yurika Matsumoto Toshihiko Takami Taro Sakaida Isao Yamasaki Takahiro Publishers : 山口大学医学会
Efficacy of quantitative analysis for differentiating pancreatic solid lesions using contrast-enhanced endoscopic ultrasonography
The bulletin of the Yamaguchi Medical School Volume 68 Issue 1-2 pp. 11 - 20
published_at 2021
Aim: To evaluate the efficacy of quantitative analysis for differentiating pancreatic ductal adenocarcinoma (PDAC) and inflammatory pancreatic masses (IPM) using time intensity curve (TIC) analysis based on contrast-enhanced endoscopic ultrasonography (CE-EUS). Methods: We reviewed 89 patients who had undergone CE-EUS for pancreatic solid lesions at our department between August 2012 and January 2016. CE-EUS images were recorded for 2 minutes after injection of the contrast agent. The diagnostic abilities of the enhanced patterns and TIC analysis were assessed. Results: The enhanced patterns of PDAC were mainly hypovascular and heterogeneous (66/77), while IPM were mainly isovascular and homogeneous (6/12). In PDAC, sensitivity was 77.9%, specificity 83.3%, and accuracy was 78.7%. In TIC analysis, the intensity reduction rate was significantly different at 10 and 30 seconds after peak intensity. After creating a cutoff value (49%) based on the receiver operating characteristic curve for the intensity reduction rate after 30 seconds, diagnosing PDAC with TIC analysis had a sensitivity of 67.5%, specificity of 100%, and accuracy of 71.9%. Combining enhanced pattern analysis with TIC analysis had a sensitivity of 90.9%, pecificity of 83.3%, and accuracy of 89.9%. Conclusion: Combining TIC analysis with CE-EUS improved diagnostic accuracy when differentiating between PDAC and IPM.
Creators : Yasuda Mayumi Kaino Seiji Tsuyama Takanori Fujimoto Yuko Amano Shogo Harima Hirofumi Suenaga Shigeyuki Sakaida Isao Publishers : Yamaguchi University School of Medicine
The last lecture: bioethics of happiness, with a special reference to the five senses and the reward system of the brain in secular spiritual care
The bulletin of the Yamaguchi Medical School Volume 59 Issue 1-2 pp. 1 - 6
published_at 2012
Creators : Tanida Noritoshi Publishers : Yamaguchi University School of Medicine
Watching the motion pictures of signal molecules of the abnormal vascular contraction! Spatiotemporal nanoscale analysis of intracellular abnormality
Time studies Volume 2 pp. 45 - 64
published_at 2008-03-31
Creators : Kawamichi Natsumi Publishers : 山口大学時間学研究所
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