山口県大学共同リポジトリ

Development of new therapy in fulminant hepatitis from glucagon-insulin therapy to bone marrow cell transplantation

The bulletin of the Yamaguchi Medical School Volume 52 Issue 3-4 pp. 25 - 31

published_at 2005-12

Application of cell therapy using stem cell into intractable diseases has been noted as the medicine in the next generation taking the place of organ transplantation. Bone marrow cells have been focused as a candidate of the source of this therapy. Liver failure is a terminal state of all advanced liver diseases and thousands of patients are dying of decompensated liver cirrhosis in every year in Japan. Liver transplantation must be the strongest weapon to relieve those patients. However, particularly in Japan, liver transplantation has not been popularized. In this sense, we thought of autologous bone marrow cells transplantation for decompensated liver cirrhosis. Basic studies using animal model revealed that transplanted bone marrow cells into syngenic mouse suffering from liver cirrhosis migrated into the damaged liver and transdifferentiated to the hepatocytes. Based upon the animal studies, clinical trial of this new cell therapy supported by the Ministry of Health, Labor and Welfare is ongoing. It is early to estimate this therapy. However, free from liver failure has been observed in some cases.

Creators : Okita Kiwamu Sakaida Isao Terai Shuji Yamamoto Naoki Omori Kaoru Ishikawa Tsuyoshi Aoyama Kouji Shinoda Koh Hamamoto Yoshihiko Publishers : Yamaguchi University School of Medicine

Liquid biopsy test based on a sensitive dna methylation assay for diagnosing hepatocellular carcinoma : which is a better marker, methylated sst or sept9?

山口医学 Volume 70 Issue 3 pp. 89 - 98

published_at 2021-09-01

We performed this study to investigate whether serum cell-free DNA testing(liquid biopsy)of either methylated SEPT9 or methylated SST, which are possible biomarkers of HCC, in combination with AFP may improve clinical performance for the detection of HCC. Study subjects included 25 healthy controls, 15 patients with chronic liver disease without HCC, and 38 patients with HCC. Methylation level of serum cell-free SEPT9 and SST was measured by methylation-sensitive restriction enzymes followed by multiplex droplet digital polymerase chain reaction. According to receiver operating characteristic curve analysis to discriminate between non-HCC group(including control group and chronic liver disease without HCC group)and HCC group, area under the curve(AUC)was 0.73 by AFP and 0.73 by mSEPT9, whereas it was only 0.59 by mSST. Regarding combination tests, although negative predictive values were almost same between the AFP + mSEPT9 test and the AFP + mSST test(75.0% vs 72.2%),a positive predictive value of AFP + mSEPT9 test was higher than that of the AFP + mSST test(79.4% vs. 66.7%).In conclusions, methylated SEPT9 was a better companion marker of AFP for HCC screening than methylated SST.

Creators : Yamasaki Ayano Suehiro Yutaka Hoshida Tomomi Saeki Issei Yamauchi Kotoh Yurika Matsumoto Toshihiko Takami Taro Sakaida Isao Yamasaki Takahiro Publishers : 山口大学医学会

Efficacy of quantitative analysis for differentiating pancreatic solid lesions using contrast-enhanced endoscopic ultrasonography

The bulletin of the Yamaguchi Medical School Volume 68 Issue 1-2 pp. 11 - 20

published_at 2021

Aim: To evaluate the efficacy of quantitative analysis for differentiating pancreatic ductal adenocarcinoma (PDAC) and inflammatory pancreatic masses (IPM) using time intensity curve (TIC) analysis based on contrast-enhanced endoscopic ultrasonography (CE-EUS). Methods: We reviewed 89 patients who had undergone CE-EUS for pancreatic solid lesions at our department between August 2012 and January 2016. CE-EUS images were recorded for 2 minutes after injection of the contrast agent. The diagnostic abilities of the enhanced patterns and TIC analysis were assessed. Results: The enhanced patterns of PDAC were mainly hypovascular and heterogeneous (66/77), while IPM were mainly isovascular and homogeneous (6/12). In PDAC, sensitivity was 77.9%, specificity 83.3%, and accuracy was 78.7%. In TIC analysis, the intensity reduction rate was significantly different at 10 and 30 seconds after peak intensity. After creating a cutoff value (49%) based on the receiver operating characteristic curve for the intensity reduction rate after 30 seconds, diagnosing PDAC with TIC analysis had a sensitivity of 67.5%, specificity of 100%, and accuracy of 71.9%. Combining enhanced pattern analysis with TIC analysis had a sensitivity of 90.9%, pecificity of 83.3%, and accuracy of 89.9%. Conclusion: Combining TIC analysis with CE-EUS improved diagnostic accuracy when differentiating between PDAC and IPM.

Creators : Yasuda Mayumi Kaino Seiji Tsuyama Takanori Fujimoto Yuko Amano Shogo Harima Hirofumi Suenaga Shigeyuki Sakaida Isao Publishers : Yamaguchi University School of Medicine

A case of raspberry-like foveolar-type gastric adenocarcinoma resected by strip biopsy

山口医学 Volume 70 Issue 1 pp. 53 - 58

published_at 2021-03-04

Creators : Fujimura Hiroyuki Nishikawa Jun Hamabe Koichi Izumiya Yuta Matsumoto Satoko Yoshitomi Shingo Ito Shunsuke Yamaoka Yuko Shirasawa Tomohiro Goto Atsushi Hashimoto Shinichi Okamoto Takeshi Hoshii Yoshinobu Sakaida Isao Publishers : 山口大学医学会

MIG and I309 accelerates proliferation of human bone marrow-derived mesenchymal stem cells

The bulletin of the Yamaguchi Medical School Volume 67 Issue 1-2 pp. 1 - 10

published_at 2020

Creators : Aibe Yuki Takami Taro Fujisawa Koichi Matsumoto Toshihiko Sakaida Isao Publishers : Yamaguchi University School of Medicine

Current status of rifaximin treatment for hepatic encephalopathy at our hospital

山口医学 Volume 69 Issue 2 pp. 75 - 80

published_at 2020-05-01

Creators : Iwamoto Takuya Sakaida Isao Publishers : 山口大学医学会

Utility of real-time tissue elastography in the sequential evaluation of liver fibrosis in patients with chronic hepatitis C

The bulletin of the Yamaguchi Medical School Volume 66 Issue 1-2 pp. 29 - 35

published_at 2019

Creators : Hanazono Tadasuke Hidaka Isao Maeda Masaki Saeki Issei Iwamoto Takuya Ishikawa Tsuyoshi Takami Taro Yamasaki Takahiro Sakaida Isao Publishers : Yamaguchi University School of Medicine

Utility of contrast-enhanced ultrasonography for the evaluation of partial splenic embolization

The bulletin of the Yamaguchi Medical School Volume 66 Issue 1-2 pp. 7 - 13

published_at 2019

Creators : Fukui Yumi Saeki Issei Matsuda Takashi Maeda Masaki Hisanaga Takuro Iwamoto Takuya Matsumoto Toshihiko Hidaka Isao Ishikawa Tsuyoshi Takami Taro Yamasaki Takahiro Sakaida Isao Publishers : Yamaguchi University School of Medicine

Effectiveness of early intervention by specialized institutions for liver cirrhosis patients

山口医学 Volume 66 Issue 3 pp. 163 - 168

published_at 2017-08-01

Creators : Hisanaga Takuro Yamasaki Takahiro Maeda Masaki Iwamoto Takuya Saeki Issei Matsumoto Toshihiko Hidaka Isao Marumoto Yoshio Ishikawa Tsuyoshi Takami Taro Sakaida Isao Publishers : 山口大学医学会

Low-grade differentiated adenocarcinoma of the gastric foveolar type arising in the helicobacter pylori -negative stomach

山口医学 Volume 66 Issue 1 pp. 41 - 45

published_at 2017-02-01

Creators : Sasaki Sho Nishikawa Jun Nagao Misato Ogawa Ryo Goto Atsushi Hashimoto Shinichi Okamoto Takeshi Suzuki Chieko Hoshii Yoshinobu Sakaida Isao Publishers : 山口大学医学会

Hepatic sclerosing cavernous hemangioma mimicking a malignant liver tumor:report of a case

山口医学 Volume 65 Issue 2 pp. 101 - 107

published_at 2016-05-01

Creators : Yamaoka Yuko Mori Kenji Noguchi Norio Matsunaga Takaharu Sakaida Isao Publishers : 山口大学医学会

Four cases of ruptured duodenal varices

山口医学 Volume 64 Issue 2 pp. 145 - 152

published_at 2015-05-01

Duodenal varices（DV）are the most common of ectopic varices. Although bleeding from DV is rare, it is difficult to control bleeding and sometimes fatal. We have encountered four clinical cases of ruptured DV. Case 1：A man in his 80s presented with a history of partial gastrectomy with Billroth-II reconstruction and LC due to chronic hepatitis C. We performed single-balloon endoscopy and injected 67% N-butyl-2-cyanoacrylate（NBCA）for DV on the afferent loop with red plug. Case 2：A woman in her 40s with primary biliary cirrhosis complained of tarry stool and anemia. We performed endoscopic injection sclerotherapy（EIS）with 67% NBCA for spurting bleeding point in duodenum. Case 3：A man in his 50s with liver cirrhosis（LC）due to chronic hepatitis B complained of tarry stool. We performed endoscopic variceal ligation（EVL）and balloon-occluded retrograde transvenous obliteration（B-RTO）for DV. Case 4：A man in his 60s with alcoholic LC complained of tarry stool. We performed EIS with 67% NBCA for DV. We added EVL, clipping, and argon plasma coagulation after EIS to control bleeding. To control bleeding was achieved in all cases.

Creators : Sasaki Ryo Matsuda Takashi Aibe Yuki Nakashima Takao Shiratsuki Shogo Iwamoto Takuya Ishikawa Tsuyoshi Terai Shuji Sakaida Isao Publishers : 山口大学医学会

Successful management of walled-off necrosis and pseudo-aneurysm related with severe acute pancreatitis;a case report

山口医学 Volume 64 Issue 2 pp. 109 - 114

published_at 2014-05-01

Creators : Ogawa Ryo Kaino Seiji Shinoda Syuhei Kawano Michitaka Harima Hirofumi Suenaga Shigeyuki Ishikawa Tsuyoshi Kaino Miyuki Kurokawa Fumie Sakaida Isao Publishers : 山口大学医学会

A case of chronic hepatitis c with charcot-marie-tooth disease successfully treated with interferon beta and rivabirin combination therapy

山口医学 Volume 64 Issue 1 pp. 53 - 57

published_at 2015-02-01

A 36-year-old man diagnosed with Charcot-Marie-Tooth(CMT)disease type 1B was treated in the department of neurology of this hospital. Due to a liver injury(AST 237IU/ml, ALT 496IU/ml)which occurred in November 200X, he was introduced to our department. As a result of scrutiny, we diagnosed him with chronic hepatitis C genotype 2a(HCV-RNA 5.4logIU/ml).He will be admitted to the hospital for Interferon(IFN)therapy in April next year. Although the mechanism is unknown, there are a few reports of peripheral neuropathy related to IFN therapy. Therefore, IFN therapy is generally unfavorable for patients with neuromuscular disorders. There are several IFN preparations used in Japan. IFN alfa associated peripheral neuropathy appears less than 0.1-5% of the time. While there is no report of peripheral neuropathy related to IFN beta, we performed IFN beta and Rivabirin combination therapy with a severe follow-up by a neurologist. We could accomplish treatment without the exacerbation of neurologic symptoms. He achieved sustained viral response. When IFN therapy was provided for chronic hepatitis B or chronic hepatitis C complicated with peripheral neuropathy, there is some possibility of performing antiviral therapy safely by using IFN beta.

Creators : Matsuura Keiji Hidaka Isao Hanazono Tadasuke Saeki Issei Iwamoto Takuya Ishikawa Tsuyoshi Takami Taro Kawai Motoharu Terai Shuji Takashi Takashi Sakaida Isao Publishers : 山口大学医学会

A case of early gastric cancer that developed 6 years after eradication of helicobacter pylori for nodular gastritis

山口医学 Volume 64 Issue 1 pp. 47 - 51

published_at 2015-02-01

Creators : Yasuda Mayumi Okamoto Takeshi Nagao Misato Sasaki Sho Nishimura Junichi Nakamura Munetaka Nishikawa Jun Iida Michihisa Yoshino Shigefumi Sakaida Isao Publishers : 山口大学医学会

A case of cyclic thrombocytopenia complicated by drug-related damage to the small intestinal mucosa

山口医学 Volume 64 Issue 1 pp. 41 - 45

published_at 2015-02-01

Creators : Nishimura Tatsuro Hashimoto Shinichi Kawasato Ryo Shirasawa Tomohiro Yokota Yasuyuki Shibata Taimei Okamoto Takeshi Nishikawa Jun Sakaida Isao Publishers : 山口大学医学会

A case of ruptured hepatocellular carcinoma immediately after transcatheter arterial chemoembolization

山口医学 Volume 64 Issue 1 pp. 35 - 40

published_at 2015-02-01

Spontaneous rupture of hepatocellular carcinoma(HCC)is well known. However, rupture of HCC after transcatheter arterial chemoembolization(TACE)is a rare but potentially fatal complication. Herein, we report a case of ruptured HCC after TACE in a 73-year-old man with chronic liver injury(non-B and non-C).He had previously undergone subsegmental resection of S7 of the liver for HCC. One year later, multiple HCCs were detected. TACE was performed for the recurrent HCCs located on the surface of S2 of the liver. Epigastric pain and decreased blood pressure were observed after the treatment. Although his symptoms improved immediately, the patient gradually became anemic. Radiological examination after TACE revealed a hematoma around the S2 lesion. Therefore, we diagnosed rupture of HCC. We performed TAE and could control the bleeding. Few possible mechanisms of ruptured HCC after TACE include increasing pressure inside the tumor and capsular injury due to TACE. Consequently, HCC which has a high risk of rupture after TACE should be assured embolization and careful observation.

Creators : Fukui Yumi Saeki Issei Hanazono Tadasuke Tanabe Norikazu Urata Yohei Hidaka Isao Terai Shuji Sakaida Isao Publishers : 山口大学医学会

Active hexose-correlated compound down-regulates sex-determining region Y-box 2 of pancreatic cancer cells

Anticancer Res Volume 34 Issue 9 pp. 4807 - 4811

published_at 2014-11-01

Creators : Nawata Junya Kuramitsu Yasuhiro Wang Yufeng Kitagawa Takao Tokuda Kazuhiro Baron Byron Akada Junko Suenaga Shigeyuki Kaino Seiji Maehara Shinichiro Maehara Yoshihiko Sakaida Isao Nakamura Kazuyuki Publishers : International Institute of Anticancer Research

Correlation between changes in bodyweight and changes in ascites volume in liver cirrhosis patients with hepatic edema in short-term diuretic therapy

Hepatology research Volume 44 Issue 7 pp. 735 - 739

published_at 2014-07

Creators : Sakaida Isao Okita Kiwamu Publishers : Blackwell Publishing Ltd

A case of solid pseudopapillary neoplasm of the pancreas with massive central calcification

山口医学 Volume 63 Issue 2 pp. 153 - 159

published_at 2014-05-01

Creators : Nakashima Takao Harima Hirofumi Kawano Michitaka Suenaga Shigeyuki Uekitani Toshiyuki Sen-yo Manabu Harano Megumi Kaino Seiji Suzuki Nobuaki Oka Masaaki Sakaida Isao Publishers : 山口大学医学会

Effect of coadministration of polyethylene glycol and Dai-Kenchu-To on image definition and complete small bowel examination rate in capsule endoscopy

The bulletin of the Yamaguchi Medical School Volume 61 Issue 1-2 pp. 7 - 13

published_at 2014

Background and Aim: Image definition and complete small bowel examination rate are possible factors contributing to missed lesions during capsule endoscopy.This study aimed to determine the effect of coadministration of polyethylene glycol (PEG) and dai-kenchu-to (DKT) on these factors using PEG and DKT as pretreatment before capsule endoscopy. Methods: Patients who underwent capsule endoscopy at our hospital between November 2007 and August 2012 were included in the study. Patients were divided into the following three groups: those receiving no pretreatment (control, n=133), those orally administered PEG (PEG, n=20), and those orally administered PEG and DKT (15g) (PEG + DKT, n=25). Image definition and complete small bowel examination rate were examined retrospectively between the three groups. Results: Image definition in the PEG + DKT group was significantly higher than that in the control group (p<0.05), but there was no significant differences between the PEG and control groups. The complete small bowel examination rate was significantly lower in the PEG group than in the control and PEG + DKT groups (p<0.05). Conclusions: Coadministration of PEG and DKT improved image definition and prevented a reduction of the complete small bowel examination rate due to PEG in capsule endoscopy.

Creators : Suzuki Keiko Hashimoto Shinichi Shirasawa Tomohiro Yokota Tadayuki Kaneyama Satoko Shibata Hiroaki Tanabe Ryo Sakaida Isao Publishers : Yamaguchi University School of Medicine

Status and prospects of liver cirrhosis treatment by using bone marrow-derived cells and mesenchymal cells

Tissue engineering. Part B, Reviews Volume 20 Issue 3 pp. 206 - 210

published_at 2014-06-01

Creators : Terai Shuji Takami Taro Yamamoto Naoki Fujisawa Koichi Ishikawa Tsuyoshi Urata Yohei Tanimoto Haruko Iwamoto Takuya Mizunaga Yuko Matsuda Takashi Oono Takashi Marumoto Miho Burganova Guzel R. Quintanilha Luiz Fernando Hidaka Isao Marumoto Yoshio Saeki Issei Uchida Koichi Yamasaki Takahiro Tani Kenji Taura Yasuho Fujii Yasuhiko Nishina Hiroshi Okita Kiwamu Sakaida Isao Publishers : Mary Ann Liebert

Efficacy of i-scan imaging for the detection and diagnosis of early gastric carcinomas

Gastroenterology Research and Practice Volume 2014 pp. 819395 -

published_at 2014

Creators : Nishimura Junichi Nishikawa Jun Nakamura Munetaka Goto Atsushi Hamabe Kouichi Hashimoto Shinichi Okamoto Takeshi Suenaga Masato Fujita Yusuke Hamamoto Yoshihiko Sakaida Isao Publishers : Hindawi Publishing Corporation

New susceptibility and resistance HLA-DP alleles to HBV-related diseases identified by a trans-ethnic association study in Asia

PLoS ONE Volume 9 Issue 2 pp. e86449 -

published_at 2014-02-10

Creators : Nishida Nao Sawai Hiromi Kashiwase Koichi Minami Mutsuhiko Sugiyama Masaya Seto Wai-Kay Yuen Man-Fung Posuwan Nawarat Poovorawan Yong Ahn Sang Hoon Han Kwang-Hyub Matsuura Kentaro Tanaka Yasuhito Kurosaki Masayuki Asahina Yasuhiro Izumi Namiki Kang Jong-Hon Hige Shuhei Ide Tatsuya Yamamoto Kazuhide Sakaida Isao Murawaki Yoshikazu Itoh Yoshito Tamori Akihiro Orito Etsuro Hiasa Yoichi Honda Masao Kaneko Shuichi Mita Eiji Suzuki Kazuyuki Hino Keisuke Tanaka Eiji Mochida Satoshi Watanabe Masaaki Eguchi Yuichiro Masaki Naohiko Murata Kazumoto Korenaga Masaaki Mawatari Yoriko Ohashi Jun Kawashima Minae Tokunaga Katsushi Mizokami Masashi Publishers : Public Library of Science

Development and validation of a symptom scale specific for ascites accompanied with cirrhosis : The ASI-7

Clinical and Translational Gastroenterology Volume 5 pp. e48 -

published_at 2014-02-06

Creators : Onishi Yoshihiro Wakita Takafumi Fukuhara Shinichi Noguchi Yoshinori Okada Mitsuru Sakaida Isao Sasaki Yutaka Kobayashi Kenji Publishers : American College of Gastroenterology

Active hexose-correlated compound down-regulates HSP27 of pancreatic cancer cells, and helps the cytotoxic effect of gemcitabine

Anticancer Research Volume 34 Issue 1 pp. 141 - 146

published_at 2014-01

Creators : Suenaga Shigeyuki Kuramitsu Yasuhiro Kaino Seiji Maehara Shinichiro Maehara Yoshihiko Sakaida Isao Nakamura Kazuyuki Publishers : Potamitis Press

Tolvaptan for improvement of hepatic edema : A phase 3, multicenter, randomized, double-blind, placebo-controlled trial

Hepatology research : the official journal of the Japan Society of Hepatology Volume 44 Issue 1 pp. 73 - 82

published_at 2014-01

Creators : Sakaida Isao Kawazoe Seiji Kajimura Kozo Saito Takafumi Okuse Chiaki Takaguchi Kouichi Okada Mitsuru Okita Kiwamu ASCITES-DOUBLEBLIND Study Group Publishers : Elsevier | The Japan Society of Hepatology

Dose-finding trial of tolvaptan in liver cirrhosis patients with hepatic edema : A randomized, double-blind, placebo-controlled trial

Hepatology research : the official journal of the Japan Society of Hepatology Volume 44 Issue 1 pp. 83 - 91

published_at 2014-01

Creators : Okita Kiwamu Kawazoe Seiji Hasebe Chitomi Kajimura Kozo Kaneko Akira Okada Mitsuru Sakaida Isao ASCITES Dose-Finding Trial Group Publishers : Elsevier | The Japan Society of Hepatology

A case of endocrine cell carcinoma of the esophagus with gastric adenocarcinoma successfully treated by chemotherapy

山口医学 Volume 63 Issue 1 pp. 61 - 67

published_at 2014-02-01

Creators : Nagao Misato Okamoto Takeshi Nishimura Junnichi Nakamura Munetaka Goto Atsushi Nishikawa Jun Sakaida Isao Publishers : 山口大学医学会

A case of primary hepatic neuroendocrine carcinoma clinically suggested

山口医学 Volume 63 Issue 1 pp. 53 - 60

published_at 2014-02-01

Creators : Kawasato Ryo Shiratsuki Shogo Iwamoto Takuya Saeki Issei Urata Yohei Hidaka Isao Ishikawa Tsuyoshi Takami Taro Uchida Kouichi Terai Shuji Yamasaki Takahiro Sakaida Isao Publishers : 山口大学医学会

A case of the intraabdominal hemorrhage due to Segmental Aaterial mediolysis(SAM)

山口医学 Volume 62 Issue 4 pp. 241 - 246

published_at 2013-11-01

Creators : Noguchi Norio Hanazono Tadasuke Mori Kenji Okita Kousuke Sakaida Isao Publishers : 山口大学医学会

Efficacy and safety of a 14-day administration of tolvaptan in the treatment of patients with ascites in hepatic oedema

Journal of International Medical Research Volume 41 Issue 3 pp. 835 - 847

published_at 2013-01

Creators : Sakaida Isao Yamashita Satoyoshi Kobayashi Tomoo Komatsu Masafumi Sakai Terufumi Komorizono Yasuji Okada Mitsuru Okita Kiwamu Publishers : Cambridge Medical Publications Ltd

Human pancreatic cancer cells with acquired gemcitabine resistance exhibit significant up-regulation of Peroxiredoxin-2 compared to sensitive parental cells

Anticancer Research Volume 33 Issue 11 pp. 4821 - 4826

published_at 2013-11

Creators : Suenaga Shigeyuki Kuramitsu Yasuhiro Wang Yufeng Baron Byron Kitagawa Takao Akada Junko Tokuda Kazuhiro Kaino Seiji Maehara Shin-ichiro Maehara Yoshihiko Sakaida Isao Nakamura Kazuyuki Publishers : Potamitis Press

Usefulness of ultraslim endoscopy with flexible spectral imaging color enhancement for detection of gastric neoplasm : a preliminary study

Journal of Gastrointestinal Cancer Volume 44 Issue 3 pp. 325 - 328

published_at 2013-09

Creators : Nakamura Munetaka Nishikawa Jun Goto Atsushi Nishimura Junichi Hashimoto Shinichi Okamoto Takeshi Sakaida Isao Publishers : Humana Press

Correlations between obesity/metabolic syndrome-related factors and risk of developing colorectal tumors

Hepato-Gastroenterology Volume 60 Issue 124 pp. 733 - 737

published_at 2013-06

Creators : Harima Satoko Hashimoto Shinichi Shibata Hiroaki Matsunaga Takaharu Tanabe Ryo Terai Shuji Sakaida Isao Publishers : Georg Thieme

肝硬変・肝癌の最新治療

The Journal of the Japanese Society of Internal Medicine Volume 102 Issue 3 pp. 594 - 599

published_at 2013-03-10

Creators : 坂井田功 Publishers : 日本内科学会

Nutritional management contributes to improvement in minimal hepatic encephalopathy and quality of life in patients with liver cirrhosis : A preliminary, prospective, open-label study

Hepatology research : the official journal of the Japan Society of Hepatology Volume 43 Issue 5 pp. 452 - 458

published_at 2013-05

Creators : Kato Akinobu Tanaka Hiroto Kawaguchi Takumi Kanazawa Hidenori Iwasa Motoh Sakaida Isao Moriwaki Hisataka Murawaki Yoshikazu Suzuki Kazuyuki Okita Kiwamu Publishers : Elsevier

Outcomes of endoscopic submucosal dissection for early gastric cancer and factors associated with incomplete resection

Hepato-Gastroenterology : journal of clinical research and practice Volume 60 Issue 121 pp. 46 - 53

published_at 2013-03

Creators : Goto Atsushi Nishikawa Jun Okamoto Takeshi Hamabe Kouichi Nishimura Junnichi Nakamura Munetaka Kiyotoki Shu Saito Mari Miura Osamu Sakaida Isao Publishers : Georg Thieme

Utility of computed tomographic enteroclysis/enterography for the assessment of mucosal healing in Crohn's disease

Gastroenterology research and practice Volume 2013 pp. 984916 -

published_at 2013

Creators : Hashimoto Shinichi Shimizu Kensaku Shibata Hiroaki Kanayama Satoko Tanabe Ryo Onoda Hideko Matsunaga Naohumi Sakaida Isao Publishers : Hindawi Publishing

An improvement of liver cirrhosis classification using ultrasonic images

The transactions of the Institute of Electrical Engineers of Japan. C, A publication of Electronics, Information and Systems Society Volume 133 Issue 2 pp. 289 - 296

published_at 2013

Creators : Hayashi Takaya Fujita Yusuke Mitani Yoshihiro Hamamoto Yoshihiko Segawa Makoto Terai Shuji Sakaida Isao Publishers : 電気学会

Medaka fish, Oryzias latipes, as a model for human obesity-related glomerulopathy

Biochemical and Biophysical Research Communications Volume 431 Issue 4 pp. 712 - 717

published_at 2013

Creators : Ichimura K. Kawashima Y. Nakamura T. Powell R. Hidoh Y. Terai S. Sakaida I. Kodera Y. Tsuji T. Ma J. X. Sakai T. Matsumoto H. Obara T. Publishers : University of Chicago Press

内視鏡画像における動き情報を基にした色の強調処理

MIRU2012 第15回画像の認識・理解シンポジウム論文集

published_at 2012-08

Creators : 大高洸輝長篤志三池秀敏杉村敦彦西川潤坂井田功 Publishers : 電子情報通信学会パターン認識・メディア理解研究会（PRMU研究会） | 情報処理学会コンピュータビジョンとイメージメディア研究会（CVIM研究会）

Esophageal squamous papilloma with tentacular processes

Gastrointestinal endoscopy Volume 74 Issue 5 pp. 1143 - 1144

published_at 2011-11

Creators : Nakamura Munetaka Okamoto Takeshi Kiyotoki Shu Saito Mari Hamabe Kouichi Nishikawa Jun Sakaida Isao Publishers : American Society for Gastrointestinal Endoscopy

Surgical resection for hemorrhage in a case of brunner's gland hyperplasia that had increased over the course of 5 years

山口医学 Volume 62 Issue 1 pp. 43 - 48

published_at 2013-02-01

Creators : Shiratsuki Shogo Okamoto Takeshi Hamabe Kouichi Senyo Manabu Nishikawa Jun Hashimoto Noriaki Yoshino Shigefumi Sakaida Isao Publishers : 山口大学医学会

A case of gastric cancer was detected on survey of liver abscess

山口医学 Volume 62 Issue 1 pp. 49 - 53

published_at 2013-02-01

Creators : Hanazono Tadasuke Noguchi Norio Mori Kenji Sakaida Isao Publishers : 山口大学医学会

A case of multiple small-intestinal diverticula fraught with ulcer found by melena

山口医学 Volume 62 Issue 1 pp. 39 - 42

published_at 2013-02-01

Creators : Yokota Takayuki Hashimoto Shinichi Shibata Hiroaki Harima Satoko Sakaida Isao Publishers : 山口大学医学会

Progression from non-alcoholic steatohepatitis(NASH)to decompensated liver cirrhosis during the course of crohn’s disease : a case report

山口医学 Volume 62 Issue 1 pp. 33 - 37

published_at 2013-02-01

Creators : Tanabe Norikazu Harima Yumiko Hashimoto Shinichi Terai Shuji Yamasaki Takahiro Sakaida Isao Publishers : 山口大学医学会

A case of esophageal barrett’s adenocarcinoma forming a longitudinal elevation

山口医学 Volume 62 Issue 1 pp. 27 - 31

published_at 2013-02-01

Creators : Matsunaga Kazuhito Nishikawa Jun Nakamura Munetaka Nishimura Junichi Goto Atsushi Okamoto Takeshi Takeda Shigeru Nakamura Yohei Hoshii Yoshinobu Sakaida Isao Publishers : 山口大学医学会

A case of barium fecal stone successfully treated with polypectomy snare

山口医学 Volume 61 Issue 4 pp. 147 - 150

published_at 2012-11-01

Creators : Harima Satoko Hashimoto Shinichi Matsunaga Takaharu Tanabe Ryo Okamoto Takeshi Nishikawa Jun Sakaida Isao Publishers : 山口大学医学会

Granulocyte colony-stimulating factor and interleukin-1β are important cytokines in repair of the cirrhotic liver after bone marrow cell infusion: Comparison of humans and model mice

Cell transplantation Volume 21 Issue 11 pp. 2363 - 2375

published_at 2012

Creators : Mizunaga Yuko Terai Shuji Yamamoto Naoki Uchida Koichi Yamasaki Takahiro Nishina Hiroshi Fujita Yusuke Shinoda Koh Hamamoto Yoshihiko Sakaida Isao Publishers : Pergamon Press | Elsevier Science

The pharmacokinetics and pharmacodynamics of tolvaptan in patients with liver cirrhosis with insufficient response to conventional diuretics: A multicentre, double-blind, parallel-group, phase III study

Journal of international medical research Volume 40 Issue 6 pp. 2381 - 2393

published_at 2012

Creators : Sakaida I. Yanase M. Kobayashi Y. Yasutake T. Okada M. Okita K. Publishers : Cambridge Medical Publications Ltd

A case of enteric muco-submucosal elongated polyp

The Japanese journal of gastro-enterology Volume 109 Issue 11 pp. 1940 - 1945

published_at 2012

Creators : Nishimura Junichi Nishikawa Jun Tanabe Ryou Hashimoto Shinichi Matsunaga Takaharu Nakamura Munetaka Goto Atsushi Hamabe Kouichi Okamoto Takeshi Sakaida Isao Publishers : 日本消化器病学会

Preoperative evaluation of early colorectal cancer using an ultrasound mini probe

Hepato-Gastroenterology : journal of clinical research and practice Volume 59 Issue 118 pp. 1794 - 1799

published_at 2012-09

Creators : Tanabe Ryo Higaki Shingo Gondo Toshikazu Sakaida Isao Publishers : Georg Thieme

Autologous bone marrow cell infusion therapy for liver cirrhosis

国際統合医学会誌 Volume 3 Issue 1 pp. 55 - 58

published_at 2011-03-04

Creators : 坂井田功 Publishers : 国際統合医学会

Utility of the anterior oblique-viewing endoscope and the double-balloon enteroscope for endoscopic retrograde cholangiopancreatography in patients with billroth II gastrectomy

Gastroenterology research and practice Volume 2012 pp. 389269 -

published_at 2012-09-30

Creators : Sen-yo Manabu Kaino Seiji Suenaga Shigeyuki Uekitani Toshiyuki Yoshida Kanako Harano Megumi Sakaida Isao Publishers : Hindawi Publishing Corporation

自己骨髄細胞投与による肝再生, 修復治療

生化学 Volume 84 Issue 8 pp. 707 - 711

published_at 2012-08

Creators : 寺井崇二坂井田功 Publishers : 日本生化学会

Evaluation for serum Oncostatin M : relationship with non-alcoholic steatohepatitis

Gastroenterology Volume 54 Issue 6 pp. 690 - 693

published_at 2012-06

Creators : 寺井崇二 Oono Takashi 在津潤一大石俊之桑代紳哉松本俊彦橋本真一岡本健志戒能聖治内田耕一坂井田功 Publishers : 科学評論社

CT enteroclysis in the intestinal tract

臨床放射線 Volume 57 Issue 8 pp. 1017 - 1025

published_at 2012-08

Creators : 清水建策小野田秀子鷲田康雄松永尚文橋本真一坂井田功 Publishers : 金原出版

A novel colonoscope with high color-rendering white light-emitting diodes

Gastrointestinal endoscopy Volume 73 Issue 3 pp. 598 - 602

published_at 2011-03

Creators : Nishikawa Jun Yanai Hideo Okamoto Takeshi Higaki Shingo Hashimoto Shinichi Kurai Satoshi Sakaida Isao Publishers : Denver

A case of EMRC for basaloid squamous carcinoma of the cervical esophagus

World journal of gastrointestinal endoscopy Volume 4 Issue 8 pp. 373 - 375

published_at 2012

Creators : Nakamura Munetaka Nishikawa Jun Suenaga Shigeyuki Okamoto Takeshi Okamoto Fumiki Miura Osamu Sakaida Isao Publishers : Baishideng Publishing Group

Advanced therapies using autologous bone marrow cells for chronic liver disease

Discovery medicine Volume 14 Issue 74 pp. 7 - 12

published_at 2012-07-14

Creators : Takami Taro Terai Shuji Sakaida Isao Publishers : Discovery Medicine

Genome-wide association study confirming association of HLA-DP with protection against chronic hepatitis B and viral clearance in Japanese and Korean

PloS one Volume 7 Issue 6 pp. e39175 -

published_at 2012-07-21

Creators : Nishida Nao Sawai Hiromi Matsuura Kentaro Sugiyama Masaya Ahn Sang Hoon Park Yong Hige Shuhei Kang Jong-Hon Suzuki Kazuyuki Kurosaki Masayuki Asahina Yasuhiro Mochida Satoshi Watanabe Masaaki Tanaka Eiji Honda Masao Kaneko Shuichi Orito Etsuro Itoh Yoshito Mita Eiji Tamori Akihiro Murawaki Yoshikazu Hiasa Yoichi Sakaida Isao Korenaga Masaaki Hino Keisuke Ide Tatsuya Kawashima Minae Mawatari Yoriko Sageshima Megumi Ogasawara Yuko Koike Asako Izumi Namiki Han Kwang-Hyub Tanaka Yasuhito Tokunaga Katsushi Mizokami Masashi Publishers : Public Library of Science

Guidelines on nutritional management in Japanese patients with liver cirrhosis from the perspective of preventing hepatocellular carcinoma

Hepatology research : the official journal of the Japan Society of Hepatology Volume 42 Issue 7 pp. 621 - 626

published_at 2012-07

Creators : Suzuki Kazuyuki Endo Ryujin Kohgo Yutaka Ohtake Takaaki Ueno Yoshiyuki Kato Akinobu Suzuki Kazutomo Shiraki Ryo Moriwaki Hisataka Habu Daiki Saito Masaki Nishiguchi Shuhei Katayama Kazuhiro Sakaida Isao Publishers : Elsevier | Elsevier Science Ireland

Heat-shock protein 27 plays the key role in gemcitabine-resistance of pancreatic cancer cells

Anticancer research Volume 32 Issue 6 pp. 2295 - 2299

published_at 2012-06

Creators : Kuramitsu Yasuhiro Wang Yufeng Taba Kumiko Suenaga Shigeyuki Ryozawa Shomei Kaino Seiji Sakaida Isao Nakamura Kazuyuki Publishers : Potamitis Press

Evaluation of a novel non-invasive ^{13}C-glucose breath test for the identification of diabetes mellitus in cirrhotic patients

Hepatology research : the official journal of the Japan Society of Hepatology

published_at 2012-04-17

Creators : Tsuchiya Masako Yamasaki Takahiro Sakaida Isao Publishers : Elsevier | Elsevier Science Ireland

Hepatic arterial infusion chemotherapy in combination with pegylated interferon-α-2b for advanced hepatocellular carcinoma

Hepato-Gastroenterology : journal of clinical research and practice Volume 59 Issue 114 pp. 533 - 537

published_at 2012-03

Creators : Okita Kohsuke Yamasaki Takahiro Hamabe Satoe Saeki Issei Harima Yohei Terai Shuji Sakaida Isao Publishers : Georg Thieme

未承認薬・適応外薬使用に関する倫理審査体制の整備

日本医療薬学会年会講演要旨集 Volume 21 pp. 369 - 369

published_at 2011-09-09

Creators : 構木泰信濱田淑恵梅本誠治古川裕之坂井田功 Publishers : 日本医療薬学会年会組織委員会

Timeline for development of autologous bone marrow infusion (ABMi) therapy and perspective for future stem cell therapy

Journal of gastroenterology

published_at 2012-04-05

Creators : Terai Shuji Tanimoto Haruko Maeda Masaki Zaitsu Junichi Hisanaga Takuro Iwamoto Takuya Fujisawa Koichi Mizunaga Yuko Matsumoto Toshihiko Urata Yohei Marumoto Yoshio Hidaka Isao Ishikawa Tsuyoshi Yokoyama Yuichiro Aoyama Koji Tsuchiya Masako Takami Taro Omori Kaoru Yamamoto Naoki Segawa Makoto Uchida Koichi Yamasaki Takahiro Okita Kiwamu Sakaida Isao Publishers : Springer international | Springer-Verlag

A case of neuroendcrine tumor of the ileum with liver metastases treated with transcatheter arterial chemoembolization with degradable starch microspheres and biotherapy with octreotide

山口医学 Volume 60 Issue 6 pp. 255 - 261

published_at 2011-12-31

Creators : Oono Takashi Segawa Makoto Hashimoto Shinichi Uchida Koichi Terai Shuji Yamasaki Takahiro Hoshii Yoshinobu Sakaida Isao Publishers : 山口大学医学会

A case of undifferentiated carcinoma of the rectum

山口医学 Volume 60 Issue 6 pp. 249 - 254

published_at 2011-12-31

Creators : Nishimura Junichi Yanai Hideo Furuya Takumi Murakami Tomoyuki Hoashi Seiji Sakaida Isao Publishers : 山口大学医学会

A case of duodenal carcinoid tumor diagnosed by endoscopic ultrasonography guided fine-needle aspiration(EUS-FNA)

山口医学 Volume 60 Issue 6 pp. 243 - 248

published_at 2011-12-31

Creators : Harima Hirofumi Sen-yo Manabu Kaino Seiji Suenaga Shigeyuki Uekitani Toshiyuki Yoshida Kanako Harano Megumi Suzuki Nobuaki Oka Masaaki Sakaida Isao Publishers : 山口大学医学会

A case of ruptured duodenal varices treated by combination therapy of endoscopic variceal ligation and balloon-occluded retrograde transvenous obliteration

山口医学 Volume 60 Issue 6 pp. 237 - 242

published_at 2011-12-31

Creators : Matsuda Takashi Ishikawa Tsuyoshi Suenaga Shigeyuki Goto Atsushi Hamabe Kouichi Iwamoto Takuya Hashimoto Shinichi Nakashima Yoshiteru Okada Munemasa Uchida Koichi Terai Shuji Yamasaki Takahiro Sakaida Isao Publishers : 山口大学医学会

A case of crohn’s disease with an internal fistula, diagnosed using computed tomography enteroclysis

山口医学 Volume 60 Issue 5 pp. 185 - 190

published_at 2011-10-31

Creators : Shibata Hiroaki Hashimoto Shin-ichi Matsunaga Takaharu Tanabe Ryo Shimizu Kensaku Matsukuma Satoshi Hazama Shoichi Oka Masaaki Sakaida Isao Publishers : 山口大学医学会

Relation between awareness of medical students and the understanding of Kampo medicine

Japanese journal of oriental medicine Volume 63 Issue 1 pp. 57 - 64

published_at 2012-01-20

Creators : Iizuka Norio Uchida Kouichi Sakaida Isao Fujita Yusuke Hamamoto Yoshihiko Oka Masaaki Publishers : 日本東洋医学会

Autologous bone marrow cell infusion therapy for liver cirrhosis: Now and future

臨床病理 Volume 59 Issue 12 pp. 1092 - 1098

published_at 2011-12

Creators : Sakaida Isao Publishers : 臨床病理刊行会

Unilateral versus bilateral drainage using self-expandable metallic stent for unresectable hilar biliary obstruction

Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society Volume 23 Issue 1 pp. 43 - 48

published_at 2011-01

Creators : Iwano Hirotoshi Ryozawa Shomei Ishigaki Noriko Taba Kumiko Senyo Manabu Yoshida Kanako Sakaida Isao Publishers : Japan Gastroenterological Endoscopy Society

Efficient detection of hepatocellular carcinoma by a hybrid blood test of epigenetic and classical protein markers

Clinica chimica acta : international journal of clinical chemistry Volume 412 Issue 1-2 pp. 152 - 158

published_at 2011-01-14

Creators : Iizuka Norio Oka Masaaki Sakaida Isao Moribe Toyoki Miura Toshiaki Kimura Naoki Tamatsukuri Shigeru Ishitsuka Hideo Uchida Koichi Terai Shuji Yamashita Satoyoshi Okita Kiwamu Sakata Koichiro Karino Yoshiyasu Toyota Joji Ando Eiji Ide Tatsuya Sata Michio Tsunedomi Ryoichi Tsutsui Masahito Iida Michihisa Tokuhisa Yoshihiro Sakamoto Kazuhiko Tamesa Takao Fujita Yusuke Hamamoto Yoshihiko Publishers : Elsevier Science

KNK437 downregulates heat shock protein 27 of pancreatic cancer cells and enhances the cytotoxic effect of gemcitabine

Chemotherapy Volume 57 Issue 1 pp. 12 - 16

published_at 2011-03

Creators : Taba Kumiko Kuramitsu Yasuhiro Ryozawa Shomei Yoshida Kanako Tanaka Toshiyuki Mori-Iwamoto Sayaka Maehara Shin-ichiro Maehara Yoshihiko Sakaida Isao Nakamura Kazuyuki Publishers : Basel

Telmisartan improves nonalcoholic steatohepatitis in medaka (Oryzias latipes) by reducing macrophage infiltration and fat accumulation

Cell and tissue research Volume 344 Issue 1 pp. 125 - 134

published_at 2011-04

Creators : Kuwashiro Shinya Terai Shuji Oishi Toshiyuki Fujisawa Koichi Matsumoto Toshihiko Nishina Hiroshi Sakaida Isao Publishers : Springer

Senescence marker protein 30 (SMP30)/regucalcin (RGN) expression decreases with aging, acute liver injuries and tumors in zebrafish

Biochemical and biophysical research communications Volume 414 Issue 2 pp. 331 - 336

published_at 2011-10-22

Creators : Fujisawa Koichi Terai Shuji Hirose Yoshikazu Takami Taro Yamamoto Naoki Sakaida Isao Publishers : Academic Press

Imaging mass spectrometry reveals characteristic changes in triglyceride and phospholipid species in regenerating mouse liver

Biochemical and biophysical research communications Volume 408 Issue 1 pp. 120 - 125

published_at 2011-04-29

Creators : Miyamura Norio Nakamura Takashi Goto-Inoue Naoko Zaima Nobuhiro Hayasaka Takahiro Yamasaki Tokiwa Terai Shuji Sakaida Isao Setou Mitsutoshi Nishina Hiroshi Publishers : Academic Press

Proteomic differential display analysis for TS-1-resistant and -sensitive pancreatic cancer cells using two-dimensional gel electrophoresis and mass spectrometry

Anticancer research Volume 31 Issue 6 pp. 2103 - 2108

published_at 2011-06

Creators : Yoshida Kanako Kuramitsu Yasuhiro Murakami Kohei Ryozawa Shomei Taba Kumiko Kaino Seiji Zhang Xiulian Sakaida Isao Nakamura Kazuyuki Publishers : Potamitis Press

Up-regulation of 42 kDa tubulin alpha-6 chain fragment in well-differentiated hepatocellular carcinoma tissues from patients infected with hepatitis C virus

Anticancer research Volume 31 Issue 10 pp. 3331 - 3336

published_at 2011-10

Creators : Kuramitsu Yasuhiro Takashima Motonari Yokoyama Yuichiro Iizuka Norio Tamesa Takao Akada Junko K. Wang Yufeng Toda Toshifusa Sakaida Isao Okita Kiwamu Oka Masaaki Nakamura Kazuyuki Publishers : Potamitis Press

Melanocortin 4 receptor-deficient mice as a novel mouse model of nonalcoholic steatohepatitis

American journal of pathology Volume 179 Issue 5 pp. 2454 - 2463

published_at 2011-11

Creators : Itoh Michiko Suganami Takayoshi Nakagawa Nobutaka Tanaka Miyako Yamamoto Yukio Kamei Yasutomi Terai Shuji Sakaida Isao Ogawa Yoshihiko Publishers : American Association of Pathologists

A case of mucinous cystadenoma of the appendix with diverticulum

山口医学 Volume 60 Issue 4 pp. 117 - 121

published_at 2011-08-31

Creators : Ooga Miho Hashimoto Shinichi Matsunaga Takeshi Tanabe Ryo Okamoto Takeshi Nishikawa Jun Shimizu Kensaku Higaki Shingo Fujimura Yoshihiko Nakamura Katsue Oga Atsunori Maeda Kazunari Hazama Shouichi Oka Masaaki Sakaida Isao Publishers : 山口大学医学会

A case of 17 years old boy who was performed trans anal resection for rectal serrated adenoma

山口医学 Volume 60 Issue 1-2 pp. 11 - 16

published_at 2011-04-30

Creators : Tanimoto Haruko Maeda Kazunari Nishikawa Jun Hashimoto Shinichi Suzuki Keiko Hamabe Koichi Saito Mari Kiyotoki Shu Okamoto Takeshi Watanabe Yusaku Tsutsui Masahito Hazama Shoichi Oka Masaaki Kawauchi Shigeto Sakaida Isao Publishers : 山口大学医学会

A case of duodenal carcinoma treated by surgery and adjuvant therapy with gemcitabine

山口医学 Volume 60 Issue 1-2 pp. 5 - 10

published_at 2011-04-30

Creators : Nakamura Munetaka Nishikawa Jun Kiyotoki Shu Saito Mari Hamabe Koichi Okamoto Takeshi Yamasaki Takahiro Sakamoto Kazuhiko Oka Masaaki Gondo Toshikazu Sakaida Isao Publishers : 山口大学医学会

A case of Crohn's disease with AA amyloidosis in advanced age

山口医学 Volume 59 Issue 4 pp. 183 - 188

published_at 2010-08-31

AA型アミロイドーシスを合併したCrohn病の一例を経験した.症例は73歳女性.発熱,下痢症状の改善がないため紹介入院となった.入院時の腹部単純X線写真では著明な大腸拡張像を認め,腹部骨盤CTでも回腸から結腸にかけての浮腫状の壁肥厚と腸管周囲に膿瘍の形成,回腸の拡張像を認めた.十二指腸粘膜の内視鏡下生検を施行したところ,組織学的にAA型アミロイドーシスと診断された.大腸内視鏡検査では異常所見はなかった.小腸X線二重造影検査にて,小腸の管状狭窄と拡張,潰瘍瘢痕,類円形の潰瘍が多発していた.AA型アミロイドーシスを合併したCrohn病の診断のもとに入院･加療を行った.絶食と抗生剤点滴で腸管安静をはかると下痢などの症状は改善し,食事を流動食から固形食に変えると症状の増悪を認めた.Crohn病は栄養療法で寛解導入され,その後維持された.消化管アミロイドーシスの消化器症候もなく4年間経過良好である.

Creators : Harima Yohei Hashimoto Kazuo Higaki Shingo Mitani Nobuyuki Gondo Toshikazu Sakaida Isao Publishers : 山口大学医学会

A case of duodenal GIST treated by surgery and adjuvant therapy

山口医学 Volume 59 Issue 3 pp. 127 - 132

published_at 2010-06-30

Creators : Nakamura Munetaka Kiyotoki Shu Nishikawa Jun Saito Mari Hamabe Kouichi Okamoto Takeshi Higaki Shingo Sakamoto Kazuhiko Oka Masaaki Kawauchi Shigeto Sakaida Isao Publishers : 山口大学医学会

A case of adult cystic lymphangioma of the small bowel mesentery

山口医学 Volume 58 Issue 3 pp. 111 - 116

published_at 2009-06-30

症例は46歳男性.近医の腹部エコーで膵尾部近傍に腫瘤を認めたため当科へ紹介された.腹部CTで小腸間膜根部に約50mm大の低吸収域の腫瘤性病変を認めた.腹部MRIではT1強調像で低信号,T2強調像で高信号の多房性腫瘍を認めた.悪性の可能性も否定できず,診断的意味も含め,外科的切除を施行した.腫瘍は表面平滑,弾性軟で,他の周囲臓器への癒着は認めなかった.腫瘍は組織学的に嚢胞状リンパ管腫と診断した.リンパ管腫は小児の頭頚部に好発する良性腫瘍であるが,成人の腸間膜に発生したリンパ管腫はまれであるため報告する.

Creators : Kiyotoki Shu Nishikawa Jun Fujiwara Keiko Saito Mari Hamabe Koichi Okamoto Takeshi Higaki Shingo Tokuhisa Yoshihiro Gondo Toshikazu Oka Masaaki Sakaida Isao Publishers : 山口大学医学会

Arteriosclerosis and vascular endothelial function in chronic liver disease

The bulletin of the Yamaguchi Medical School Volume 57 Issue 3-4 pp. 33 - 40

published_at 2010

Creators : Suenaga Hiromi Sakaida Isao Korenaga Keiko Okamoto Takeshi Segawa Makoto Uchida Kouichi Hinoda Yuji Publishers : Yamaguchi University School of Medicine

Isolation of Parenchymal and Non-parenchymal Liver Cells.

山口医学 Volume 48 Issue 1 pp. 1 - 2

published_at 1999-02

Creators : Kayano Kozo Sakaida Isao Okita Kiwamu Publishers : 山口大学医学会

Therapy for liver regeneration with autologous bone marrrow cell transplantation : basic research and clinical application

山口医学 Volume 55 Issue 1 pp. 5 - 10

published_at 2006-02-28

Creators : Sakaida Isao Publishers : 山口大学医学会

Alcoholic Liver Injury Experienced in Our Department : from the Result for the Past Five Years

山口医学 Volume 35 Issue 1 pp. 17 - 22

published_at 1986-02

Creators : Nagasawa Toshiaki Kado Yuji Sakaida Isao Sanuki Kazutoshi Hino Keisuke Ogino Keiki Nawata Hiroshi Shingai Yasushi Yasunaga Mitsuru Ezaki Takarou Ando Keijirou Okita Kiwamu Takemoto Tadayoshi Publishers : 山口大学医学会

Management of unresectable hilar biliary obstruction : Plastic stents versus metallic stents and unilateral versus bilateral biliary drainage

The bulletin of the Yamaguchi Medical School Volume 55 Issue 1-2 pp. 9 - 14

published_at 2008

Creators : Iwano Hirotoshi Ryozawa Shomei Harano Megumi Iwamoto Sayaka Ishigaki Noriko Taba kumiko Sakaida Isao Publishers : Yamaguchi University School of Medicine

16. 当科における近年の薬物性肝障害の動向について

pp. 93 - 97

published_at 2008-10

Creators : Segawa Makoto 大森薫山口裕樹内田耕一是永圭子是永匡紹寺井崇二山崎隆弘坂井田功 Publishers : 中外医学社

Effects on liver functions of gastric variceal therapy by endoscopic ligation using a detachable snare and sclerotherapy with O-ring ligation

Hepatology research : the official journal of the Japan Society of Hepatology Volume 24 Issue 4 pp. 420 - 428

published_at 2002

Creators : Segawa Makoto Sakaida Isao Takeo Yoshifumi Harada Toshiya Yoshida Tomoharu Okita Kiwamu Publishers : Elsevier

Antioxidant, N-acetyl-L-cysteine inhibits the expression of the collagen α2 (I) promoter in the activated human hepatic stellate cell line in the absence as well as the presence of transforming growth factor-β

Hepatology research : the official journal of the Japan Society of Hepatology Volume 24 Issue 3 pp. 305 - 315

published_at 2002

Creators : Segawa Makoto Kayano Kozo Sakaguchi Eiki Okamoto Mariko Sakaida Isao Okita Kiwamu Publishers : Elsevier

Hepatic fibrogenesis and carcinogenesis

The bulletin of the Yamaguchi Medical School Volume 43 Issue 3-4 pp. 45 - 48

published_at 1996-12

Creators : Sakaida Isao Publishers : Yamaguchi University Graduate School of Medicine

Effect of late evening snacks on patients with cirrhosis

Clinical gastroenterology Volume 23 Issue 6 pp. 721 - 725

published_at 2008

Creators : Segawa Makoto Sakaida Isao Publishers : 日本メディカルセンター