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Sakaida Isao

Affiliate Master Yamaguchi University

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Application of cell therapy using stem cell into intractable diseases has been noted as the medicine in the next generation taking the place of organ transplantation. Bone marrow cells have been focused as a candidate of the source of this therapy. Liver failure is a terminal state of all advanced liver diseases and thousands of patients are dying of decompensated liver cirrhosis in every year in Japan. Liver transplantation must be the strongest weapon to relieve those patients. However, particularly in Japan, liver transplantation has not been popularized. In this sense, we thought of autologous bone marrow cells transplantation for decompensated liver cirrhosis. Basic studies using animal model revealed that transplanted bone marrow cells into syngenic mouse suffering from liver cirrhosis migrated into the damaged liver and transdifferentiated to the hepatocytes. Based upon the animal studies, clinical trial of this new cell therapy supported by the Ministry of Health, Labor and Welfare is ongoing. It is early to estimate this therapy. However, free from liver failure has been observed in some cases.
Creators : Okita Kiwamu Sakaida Isao Terai Shuji Yamamoto Naoki Omori Kaoru Ishikawa Tsuyoshi Aoyama Kouji Shinoda Koh Hamamoto Yoshihiko Publishers : Yamaguchi University School of Medicine
山口医学 Volume 70 Issue 3 pp. 89 - 98
published_at 2021-09-01
We performed this study to investigate whether serum cell-free DNA testing(liquid biopsy)of either methylated SEPT9 or methylated SST, which are possible biomarkers of HCC, in combination with AFP may improve clinical performance for the detection of HCC. Study subjects included 25 healthy controls, 15 patients with chronic liver disease without HCC, and 38 patients with HCC. Methylation level of serum cell-free SEPT9 and SST was measured by methylation-sensitive restriction enzymes followed by multiplex droplet digital polymerase chain reaction. According to receiver operating characteristic curve analysis to discriminate between non-HCC group(including control group and chronic liver disease without HCC group)and HCC group, area under the curve(AUC)was 0.73 by AFP and 0.73 by mSEPT9, whereas it was only 0.59 by mSST. Regarding combination tests, although negative predictive values were almost same between the AFP + mSEPT9 test and the AFP + mSST test(75.0% vs 72.2%),a positive predictive value of AFP + mSEPT9 test was higher than that of the AFP + mSST test(79.4% vs. 66.7%).In conclusions, methylated SEPT9 was a better companion marker of AFP for HCC screening than methylated SST.
Aim: To evaluate the efficacy of quantitative analysis for differentiating pancreatic ductal adenocarcinoma (PDAC) and inflammatory pancreatic masses (IPM) using time intensity curve (TIC) analysis based on contrast-enhanced endoscopic ultrasonography (CE-EUS). Methods: We reviewed 89 patients who had undergone CE-EUS for pancreatic solid lesions at our department between August 2012 and January 2016. CE-EUS images were recorded for 2 minutes after injection of the contrast agent. The diagnostic abilities of the enhanced patterns and TIC analysis were assessed. Results: The enhanced patterns of PDAC were mainly hypovascular and heterogeneous (66/77), while IPM were mainly isovascular and homogeneous (6/12). In PDAC, sensitivity was 77.9%, specificity 83.3%, and accuracy was 78.7%. In TIC analysis, the intensity reduction rate was significantly different at 10 and 30 seconds after peak intensity. After creating a cutoff value (49%) based on the receiver operating characteristic curve for the intensity reduction rate after 30 seconds, diagnosing PDAC with TIC analysis had a sensitivity of 67.5%, specificity of 100%, and accuracy of 71.9%. Combining enhanced pattern analysis with TIC analysis had a sensitivity of 90.9%, pecificity of 83.3%, and accuracy of 89.9%. Conclusion: Combining TIC analysis with CE-EUS improved diagnostic accuracy when differentiating between PDAC and IPM.
Creators : Yasuda Mayumi Kaino Seiji Tsuyama Takanori Fujimoto Yuko Amano Shogo Harima Hirofumi Suenaga Shigeyuki Sakaida Isao Publishers : Yamaguchi University School of Medicine
山口医学 Volume 69 Issue 2 pp. 75 - 80
published_at 2020-05-01
Creators : Iwamoto Takuya Sakaida Isao Publishers : 山口大学医学会
山口医学 Volume 65 Issue 2 pp. 101 - 107
published_at 2016-05-01
Creators : Yamaoka Yuko Mori Kenji Noguchi Norio Matsunaga Takaharu Sakaida Isao Publishers : 山口大学医学会
山口医学 Volume 64 Issue 2 pp. 145 - 152
published_at 2015-05-01
Duodenal varices(DV)are the most common of ectopic varices. Although bleeding from DV is rare, it is difficult to control bleeding and sometimes fatal. We have encountered four clinical cases of ruptured DV. Case 1:A man in his 80s presented with a history of partial gastrectomy with Billroth-II reconstruction and LC due to chronic hepatitis C. We performed single-balloon endoscopy and injected 67% N-butyl-2-cyanoacrylate(NBCA)for DV on the afferent loop with red plug. Case 2:A woman in her 40s with primary biliary cirrhosis complained of tarry stool and anemia. We performed endoscopic injection sclerotherapy(EIS)with 67% NBCA for spurting bleeding point in duodenum. Case 3:A man in his 50s with liver cirrhosis(LC)due to chronic hepatitis B complained of tarry stool. We performed endoscopic variceal ligation(EVL)and balloon-occluded retrograde transvenous obliteration(B-RTO)for DV. Case 4:A man in his 60s with alcoholic LC complained of tarry stool. We performed EIS with 67% NBCA for DV. We added EVL, clipping, and argon plasma coagulation after EIS to control bleeding. To control bleeding was achieved in all cases.
Creators : Sasaki Ryo Matsuda Takashi Aibe Yuki Nakashima Takao Shiratsuki Shogo Iwamoto Takuya Ishikawa Tsuyoshi Terai Shuji Sakaida Isao Publishers : 山口大学医学会
山口医学 Volume 64 Issue 1 pp. 53 - 57
published_at 2015-02-01
A 36-year-old man diagnosed with Charcot-Marie-Tooth(CMT)disease type 1B was treated in the department of neurology of this hospital. Due to a liver injury(AST 237IU/ml, ALT 496IU/ml)which occurred in November 200X, he was introduced to our department. As a result of scrutiny, we diagnosed him with chronic hepatitis C genotype 2a(HCV-RNA 5.4logIU/ml).He will be admitted to the hospital for Interferon(IFN)therapy in April next year. Although the mechanism is unknown, there are a few reports of peripheral neuropathy related to IFN therapy. Therefore, IFN therapy is generally unfavorable for patients with neuromuscular disorders. There are several IFN preparations used in Japan. IFN alfa associated peripheral neuropathy appears less than 0.1-5% of the time. While there is no report of peripheral neuropathy related to IFN beta, we performed IFN beta and Rivabirin combination therapy with a severe follow-up by a neurologist. We could accomplish treatment without the exacerbation of neurologic symptoms. He achieved sustained viral response. When IFN therapy was provided for chronic hepatitis B or chronic hepatitis C complicated with peripheral neuropathy, there is some possibility of performing antiviral therapy safely by using IFN beta.
山口医学 Volume 64 Issue 1 pp. 35 - 40
published_at 2015-02-01
Spontaneous rupture of hepatocellular carcinoma(HCC)is well known. However, rupture of HCC after transcatheter arterial chemoembolization(TACE)is a rare but potentially fatal complication. Herein, we report a case of ruptured HCC after TACE in a 73-year-old man with chronic liver injury(non-B and non-C).He had previously undergone subsegmental resection of S7 of the liver for HCC. One year later, multiple HCCs were detected. TACE was performed for the recurrent HCCs located on the surface of S2 of the liver. Epigastric pain and decreased blood pressure were observed after the treatment. Although his symptoms improved immediately, the patient gradually became anemic. Radiological examination after TACE revealed a hematoma around the S2 lesion. Therefore, we diagnosed rupture of HCC. We performed TAE and could control the bleeding. Few possible mechanisms of ruptured HCC after TACE include increasing pressure inside the tumor and capsular injury due to TACE. Consequently, HCC which has a high risk of rupture after TACE should be assured embolization and careful observation.
Creators : Fukui Yumi Saeki Issei Hanazono Tadasuke Tanabe Norikazu Urata Yohei Hidaka Isao Terai Shuji Sakaida Isao Publishers : 山口大学医学会
Anticancer Res Volume 34 Issue 9 pp. 4807 - 4811
published_at 2014-11-01
Creators : Nawata Junya Kuramitsu Yasuhiro Wang Yufeng Kitagawa Takao Tokuda Kazuhiro Baron Byron Akada Junko Suenaga Shigeyuki Kaino Seiji Maehara Shinichiro Maehara Yoshihiko Sakaida Isao Nakamura Kazuyuki Publishers : International Institute of Anticancer Research
Hepatology research Volume 44 Issue 7 pp. 735 - 739
published_at 2014-07
Creators : Sakaida Isao Okita Kiwamu Publishers : Blackwell Publishing Ltd
山口医学 Volume 63 Issue 2 pp. 153 - 159
published_at 2014-05-01
Creators : Nakashima Takao Harima Hirofumi Kawano Michitaka Suenaga Shigeyuki Uekitani Toshiyuki Sen-yo Manabu Harano Megumi Kaino Seiji Suzuki Nobuaki Oka Masaaki Sakaida Isao Publishers : 山口大学医学会
Background and Aim: Image definition and complete small bowel examination rate are possible factors contributing to missed lesions during capsule endoscopy.This study aimed to determine the effect of coadministration of polyethylene glycol (PEG) and dai-kenchu-to (DKT) on these factors using PEG and DKT as pretreatment before capsule endoscopy. Methods: Patients who underwent capsule endoscopy at our hospital between November 2007 and August 2012 were included in the study. Patients were divided into the following three groups: those receiving no pretreatment (control, n=133), those orally administered PEG (PEG, n=20), and those orally administered PEG and DKT (15g) (PEG + DKT, n=25). Image definition and complete small bowel examination rate were examined retrospectively between the three groups. Results: Image definition in the PEG + DKT group was significantly higher than that in the control group (p<0.05), but there was no significant differences between the PEG and control groups. The complete small bowel examination rate was significantly lower in the PEG group than in the control and PEG + DKT groups (p<0.05). Conclusions: Coadministration of PEG and DKT improved image definition and prevented a reduction of the complete small bowel examination rate due to PEG in capsule endoscopy.
Creators : Suzuki Keiko Hashimoto Shinichi Shirasawa Tomohiro Yokota Tadayuki Kaneyama Satoko Shibata Hiroaki Tanabe Ryo Sakaida Isao Publishers : Yamaguchi University School of Medicine
Tissue engineering. Part B, Reviews Volume 20 Issue 3 pp. 206 - 210
published_at 2014-06-01
Creators : Terai Shuji Takami Taro Yamamoto Naoki Fujisawa Koichi Ishikawa Tsuyoshi Urata Yohei Tanimoto Haruko Iwamoto Takuya Mizunaga Yuko Matsuda Takashi Oono Takashi Marumoto Miho Burganova Guzel R. Quintanilha Luiz Fernando Hidaka Isao Marumoto Yoshio Saeki Issei Uchida Koichi Yamasaki Takahiro Tani Kenji Taura Yasuho Fujii Yasuhiko Nishina Hiroshi Okita Kiwamu Sakaida Isao Publishers : Mary Ann Liebert
Gastroenterology Research and Practice Volume 2014 pp. 819395 -
published_at 2014
Creators : Nishimura Junichi Nishikawa Jun Nakamura Munetaka Goto Atsushi Hamabe Kouichi Hashimoto Shinichi Okamoto Takeshi Suenaga Masato Fujita Yusuke Hamamoto Yoshihiko Sakaida Isao Publishers : Hindawi Publishing Corporation
PLoS ONE Volume 9 Issue 2 pp. e86449 -
published_at 2014-02-10
Creators : Nishida Nao Sawai Hiromi Kashiwase Koichi Minami Mutsuhiko Sugiyama Masaya Seto Wai-Kay Yuen Man-Fung Posuwan Nawarat Poovorawan Yong Ahn Sang Hoon Han Kwang-Hyub Matsuura Kentaro Tanaka Yasuhito Kurosaki Masayuki Asahina Yasuhiro Izumi Namiki Kang Jong-Hon Hige Shuhei Ide Tatsuya Yamamoto Kazuhide Sakaida Isao Murawaki Yoshikazu Itoh Yoshito Tamori Akihiro Orito Etsuro Hiasa Yoichi Honda Masao Kaneko Shuichi Mita Eiji Suzuki Kazuyuki Hino Keisuke Tanaka Eiji Mochida Satoshi Watanabe Masaaki Eguchi Yuichiro Masaki Naohiko Murata Kazumoto Korenaga Masaaki Mawatari Yoriko Ohashi Jun Kawashima Minae Tokunaga Katsushi Mizokami Masashi Publishers : Public Library of Science
Clinical and Translational Gastroenterology Volume 5 pp. e48 -
published_at 2014-02-06
Creators : Onishi Yoshihiro Wakita Takafumi Fukuhara Shinichi Noguchi Yoshinori Okada Mitsuru Sakaida Isao Sasaki Yutaka Kobayashi Kenji Publishers : American College of Gastroenterology
Anticancer Research Volume 34 Issue 1 pp. 141 - 146
published_at 2014-01
Creators : Suenaga Shigeyuki Kuramitsu Yasuhiro Kaino Seiji Maehara Shinichiro Maehara Yoshihiko Sakaida Isao Nakamura Kazuyuki Publishers : Potamitis Press
Hepatology research : the official journal of the Japan Society of Hepatology Volume 44 Issue 1 pp. 73 - 82
published_at 2014-01
Creators : Sakaida Isao Kawazoe Seiji Kajimura Kozo Saito Takafumi Okuse Chiaki Takaguchi Kouichi Okada Mitsuru Okita Kiwamu ASCITES-DOUBLEBLIND Study Group Publishers : Elsevier | The Japan Society of Hepatology
Hepatology research : the official journal of the Japan Society of Hepatology Volume 44 Issue 1 pp. 83 - 91
published_at 2014-01
Creators : Okita Kiwamu Kawazoe Seiji Hasebe Chitomi Kajimura Kozo Kaneko Akira Okada Mitsuru Sakaida Isao ASCITES Dose-Finding Trial Group Publishers : Elsevier | The Japan Society of Hepatology
山口医学 Volume 62 Issue 4 pp. 241 - 246
published_at 2013-11-01
Creators : Noguchi Norio Hanazono Tadasuke Mori Kenji Okita Kousuke Sakaida Isao Publishers : 山口大学医学会
Journal of International Medical Research Volume 41 Issue 3 pp. 835 - 847
published_at 2013-01
Creators : Sakaida Isao Yamashita Satoyoshi Kobayashi Tomoo Komatsu Masafumi Sakai Terufumi Komorizono Yasuji Okada Mitsuru Okita Kiwamu Publishers : Cambridge Medical Publications Ltd
Anticancer Research Volume 33 Issue 11 pp. 4821 - 4826
published_at 2013-11
Creators : Suenaga Shigeyuki Kuramitsu Yasuhiro Wang Yufeng Baron Byron Kitagawa Takao Akada Junko Tokuda Kazuhiro Kaino Seiji Maehara Shin-ichiro Maehara Yoshihiko Sakaida Isao Nakamura Kazuyuki Publishers : Potamitis Press
Journal of Gastrointestinal Cancer Volume 44 Issue 3 pp. 325 - 328
published_at 2013-09
Creators : Nakamura Munetaka Nishikawa Jun Goto Atsushi Nishimura Junichi Hashimoto Shinichi Okamoto Takeshi Sakaida Isao Publishers : Humana Press
Hepato-Gastroenterology Volume 60 Issue 124 pp. 733 - 737
published_at 2013-06
Creators : Harima Satoko Hashimoto Shinichi Shibata Hiroaki Matsunaga Takaharu Tanabe Ryo Terai Shuji Sakaida Isao Publishers : Georg Thieme
The Journal of the Japanese Society of Internal Medicine Volume 102 Issue 3 pp. 594 - 599
published_at 2013-03-10
Creators : 坂井田 功 Publishers : 日本内科学会
Hepatology research : the official journal of the Japan Society of Hepatology Volume 43 Issue 5 pp. 452 - 458
published_at 2013-05
Creators : Kato Akinobu Tanaka Hiroto Kawaguchi Takumi Kanazawa Hidenori Iwasa Motoh Sakaida Isao Moriwaki Hisataka Murawaki Yoshikazu Suzuki Kazuyuki Okita Kiwamu Publishers : Elsevier
Hepato-Gastroenterology : journal of clinical research and practice Volume 60 Issue 121 pp. 46 - 53
published_at 2013-03
Creators : Goto Atsushi Nishikawa Jun Okamoto Takeshi Hamabe Kouichi Nishimura Junnichi Nakamura Munetaka Kiyotoki Shu Saito Mari Miura Osamu Sakaida Isao Publishers : Georg Thieme
Gastroenterology research and practice Volume 2013 pp. 984916 -
published_at 2013
Creators : Hashimoto Shinichi Shimizu Kensaku Shibata Hiroaki Kanayama Satoko Tanabe Ryo Onoda Hideko Matsunaga Naohumi Sakaida Isao Publishers : Hindawi Publishing
The transactions of the Institute of Electrical Engineers of Japan. C, A publication of Electronics, Information and Systems Society Volume 133 Issue 2 pp. 289 - 296
published_at 2013
Creators : Hayashi Takaya Fujita Yusuke Mitani Yoshihiro Hamamoto Yoshihiko Segawa Makoto Terai Shuji Sakaida Isao Publishers : 電気学会
Biochemical and Biophysical Research Communications Volume 431 Issue 4 pp. 712 - 717
published_at 2013
Creators : Ichimura K. Kawashima Y. Nakamura T. Powell R. Hidoh Y. Terai S. Sakaida I. Kodera Y. Tsuji T. Ma J. X. Sakai T. Matsumoto H. Obara T. Publishers : University of Chicago Press
MIRU2012 第15回画像の認識・理解シンポジウム 論文集
published_at 2012-08
Creators : 大高 洸輝 長 篤志 三池 秀敏 杉村 敦彦 西川 潤 坂井田 功 Publishers : 電子情報通信学会 パターン認識・メディア理解研究会(PRMU研究会) | 情報処理学会コンピュータビジョンとイメージメディア研究会(CVIM研究会)
Gastrointestinal endoscopy Volume 74 Issue 5 pp. 1143 - 1144
published_at 2011-11
Creators : Nakamura Munetaka Okamoto Takeshi Kiyotoki Shu Saito Mari Hamabe Kouichi Nishikawa Jun Sakaida Isao Publishers : American Society for Gastrointestinal Endoscopy
山口医学 Volume 62 Issue 1 pp. 49 - 53
published_at 2013-02-01
Creators : Hanazono Tadasuke Noguchi Norio Mori Kenji Sakaida Isao Publishers : 山口大学医学会
山口医学 Volume 61 Issue 4 pp. 147 - 150
published_at 2012-11-01
Creators : Harima Satoko Hashimoto Shinichi Matsunaga Takaharu Tanabe Ryo Okamoto Takeshi Nishikawa Jun Sakaida Isao Publishers : 山口大学医学会
Journal of international medical research Volume 40 Issue 6 pp. 2381 - 2393
published_at 2012
Creators : Sakaida I. Yanase M. Kobayashi Y. Yasutake T. Okada M. Okita K. Publishers : Cambridge Medical Publications Ltd
The Japanese journal of gastro-enterology Volume 109 Issue 11 pp. 1940 - 1945
published_at 2012
Creators : Nishimura Junichi Nishikawa Jun Tanabe Ryou Hashimoto Shinichi Matsunaga Takaharu Nakamura Munetaka Goto Atsushi Hamabe Kouichi Okamoto Takeshi Sakaida Isao Publishers : 日本消化器病学会
Hepato-Gastroenterology : journal of clinical research and practice Volume 59 Issue 118 pp. 1794 - 1799
published_at 2012-09
Creators : Tanabe Ryo Higaki Shingo Gondo Toshikazu Sakaida Isao Publishers : Georg Thieme
国際統合医学会誌 Volume 3 Issue 1 pp. 55 - 58
published_at 2011-03-04
Creators : 坂井田 功 Publishers : 国際統合医学会
Gastroenterology research and practice Volume 2012 pp. 389269 -
published_at 2012-09-30
Creators : Sen-yo Manabu Kaino Seiji Suenaga Shigeyuki Uekitani Toshiyuki Yoshida Kanako Harano Megumi Sakaida Isao Publishers : Hindawi Publishing Corporation
生化学 Volume 84 Issue 8 pp. 707 - 711
published_at 2012-08
Creators : 寺井 崇二 坂井田 功 Publishers : 日本生化学会
Gastroenterology Volume 54 Issue 6 pp. 690 - 693
published_at 2012-06
Creators : 寺井 崇二 Oono Takashi 在津 潤一 大石 俊之 桑代 紳哉 松本 俊彦 橋本 真一 岡本 健志 戒能 聖治 内田 耕一 坂井田 功 Publishers : 科学評論社
臨床放射線 Volume 57 Issue 8 pp. 1017 - 1025
published_at 2012-08
Creators : 清水 建策 小野田 秀子 鷲田 康雄 松永 尚文 橋本 真一 坂井田 功 Publishers : 金原出版
Gastrointestinal endoscopy Volume 73 Issue 3 pp. 598 - 602
published_at 2011-03
Creators : Nishikawa Jun Yanai Hideo Okamoto Takeshi Higaki Shingo Hashimoto Shinichi Kurai Satoshi Sakaida Isao Publishers : Denver
World journal of gastrointestinal endoscopy Volume 4 Issue 8 pp. 373 - 375
published_at 2012
Creators : Nakamura Munetaka Nishikawa Jun Suenaga Shigeyuki Okamoto Takeshi Okamoto Fumiki Miura Osamu Sakaida Isao Publishers : Baishideng Publishing Group
Discovery medicine Volume 14 Issue 74 pp. 7 - 12
published_at 2012-07-14
Creators : Takami Taro Terai Shuji Sakaida Isao Publishers : Discovery Medicine
PloS one Volume 7 Issue 6 pp. e39175 -
published_at 2012-07-21
Creators : Nishida Nao Sawai Hiromi Matsuura Kentaro Sugiyama Masaya Ahn Sang Hoon Park Yong Hige Shuhei Kang Jong-Hon Suzuki Kazuyuki Kurosaki Masayuki Asahina Yasuhiro Mochida Satoshi Watanabe Masaaki Tanaka Eiji Honda Masao Kaneko Shuichi Orito Etsuro Itoh Yoshito Mita Eiji Tamori Akihiro Murawaki Yoshikazu Hiasa Yoichi Sakaida Isao Korenaga Masaaki Hino Keisuke Ide Tatsuya Kawashima Minae Mawatari Yoriko Sageshima Megumi Ogasawara Yuko Koike Asako Izumi Namiki Han Kwang-Hyub Tanaka Yasuhito Tokunaga Katsushi Mizokami Masashi Publishers : Public Library of Science
Hepatology research : the official journal of the Japan Society of Hepatology Volume 42 Issue 7 pp. 621 - 626
published_at 2012-07
Creators : Suzuki Kazuyuki Endo Ryujin Kohgo Yutaka Ohtake Takaaki Ueno Yoshiyuki Kato Akinobu Suzuki Kazutomo Shiraki Ryo Moriwaki Hisataka Habu Daiki Saito Masaki Nishiguchi Shuhei Katayama Kazuhiro Sakaida Isao Publishers : Elsevier | Elsevier Science Ireland
Anticancer research Volume 32 Issue 6 pp. 2295 - 2299
published_at 2012-06
Creators : Kuramitsu Yasuhiro Wang Yufeng Taba Kumiko Suenaga Shigeyuki Ryozawa Shomei Kaino Seiji Sakaida Isao Nakamura Kazuyuki Publishers : Potamitis Press
Hepatology research : the official journal of the Japan Society of Hepatology
published_at 2012-04-17
Creators : Tsuchiya Masako Yamasaki Takahiro Sakaida Isao Publishers : Elsevier | Elsevier Science Ireland
Hepato-Gastroenterology : journal of clinical research and practice Volume 59 Issue 114 pp. 533 - 537
published_at 2012-03
Creators : Okita Kohsuke Yamasaki Takahiro Hamabe Satoe Saeki Issei Harima Yohei Terai Shuji Sakaida Isao Publishers : Georg Thieme
日本医療薬学会年会講演要旨集 Volume 21 pp. 369 - 369
published_at 2011-09-09
Creators : 構木 泰信 濱田 淑恵 梅本 誠治 古川 裕之 坂井田 功 Publishers : 日本医療薬学会年会組織委員会
Journal of gastroenterology
published_at 2012-04-05
Creators : Terai Shuji Tanimoto Haruko Maeda Masaki Zaitsu Junichi Hisanaga Takuro Iwamoto Takuya Fujisawa Koichi Mizunaga Yuko Matsumoto Toshihiko Urata Yohei Marumoto Yoshio Hidaka Isao Ishikawa Tsuyoshi Yokoyama Yuichiro Aoyama Koji Tsuchiya Masako Takami Taro Omori Kaoru Yamamoto Naoki Segawa Makoto Uchida Koichi Yamasaki Takahiro Okita Kiwamu Sakaida Isao Publishers : Springer international | Springer-Verlag
山口医学 Volume 60 Issue 6 pp. 249 - 254
published_at 2011-12-31
Creators : Nishimura Junichi Yanai Hideo Furuya Takumi Murakami Tomoyuki Hoashi Seiji Sakaida Isao Publishers : 山口大学医学会
山口医学 Volume 60 Issue 6 pp. 243 - 248
published_at 2011-12-31
Creators : Harima Hirofumi Sen-yo Manabu Kaino Seiji Suenaga Shigeyuki Uekitani Toshiyuki Yoshida Kanako Harano Megumi Suzuki Nobuaki Oka Masaaki Sakaida Isao Publishers : 山口大学医学会
山口医学 Volume 60 Issue 5 pp. 185 - 190
published_at 2011-10-31
Creators : Shibata Hiroaki Hashimoto Shin-ichi Matsunaga Takaharu Tanabe Ryo Shimizu Kensaku Matsukuma Satoshi Hazama Shoichi Oka Masaaki Sakaida Isao Publishers : 山口大学医学会
Japanese journal of oriental medicine Volume 63 Issue 1 pp. 57 - 64
published_at 2012-01-20
臨床病理 Volume 59 Issue 12 pp. 1092 - 1098
published_at 2011-12
Creators : Sakaida Isao Publishers : 臨床病理刊行会
Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society Volume 23 Issue 1 pp. 43 - 48
published_at 2011-01
Creators : Iwano Hirotoshi Ryozawa Shomei Ishigaki Noriko Taba Kumiko Senyo Manabu Yoshida Kanako Sakaida Isao Publishers : Japan Gastroenterological Endoscopy Society
Clinica chimica acta : international journal of clinical chemistry Volume 412 Issue 1-2 pp. 152 - 158
published_at 2011-01-14
Creators : Iizuka Norio Oka Masaaki Sakaida Isao Moribe Toyoki Miura Toshiaki Kimura Naoki Tamatsukuri Shigeru Ishitsuka Hideo Uchida Koichi Terai Shuji Yamashita Satoyoshi Okita Kiwamu Sakata Koichiro Karino Yoshiyasu Toyota Joji Ando Eiji Ide Tatsuya Sata Michio Tsunedomi Ryoichi Tsutsui Masahito Iida Michihisa Tokuhisa Yoshihiro Sakamoto Kazuhiko Tamesa Takao Fujita Yusuke Hamamoto Yoshihiko Publishers : Elsevier Science
Chemotherapy Volume 57 Issue 1 pp. 12 - 16
published_at 2011-03
Creators : Taba Kumiko Kuramitsu Yasuhiro Ryozawa Shomei Yoshida Kanako Tanaka Toshiyuki Mori-Iwamoto Sayaka Maehara Shin-ichiro Maehara Yoshihiko Sakaida Isao Nakamura Kazuyuki Publishers : Basel
Cell and tissue research Volume 344 Issue 1 pp. 125 - 134
published_at 2011-04
Creators : Kuwashiro Shinya Terai Shuji Oishi Toshiyuki Fujisawa Koichi Matsumoto Toshihiko Nishina Hiroshi Sakaida Isao Publishers : Springer
Biochemical and biophysical research communications Volume 414 Issue 2 pp. 331 - 336
published_at 2011-10-22
Biochemical and biophysical research communications Volume 408 Issue 1 pp. 120 - 125
published_at 2011-04-29
Creators : Miyamura Norio Nakamura Takashi Goto-Inoue Naoko Zaima Nobuhiro Hayasaka Takahiro Yamasaki Tokiwa Terai Shuji Sakaida Isao Setou Mitsutoshi Nishina Hiroshi Publishers : Academic Press
Anticancer research Volume 31 Issue 6 pp. 2103 - 2108
published_at 2011-06
Creators : Yoshida Kanako Kuramitsu Yasuhiro Murakami Kohei Ryozawa Shomei Taba Kumiko Kaino Seiji Zhang Xiulian Sakaida Isao Nakamura Kazuyuki Publishers : Potamitis Press
Anticancer research Volume 31 Issue 10 pp. 3331 - 3336
published_at 2011-10
Creators : Kuramitsu Yasuhiro Takashima Motonari Yokoyama Yuichiro Iizuka Norio Tamesa Takao Akada Junko K. Wang Yufeng Toda Toshifusa Sakaida Isao Okita Kiwamu Oka Masaaki Nakamura Kazuyuki Publishers : Potamitis Press
American journal of pathology Volume 179 Issue 5 pp. 2454 - 2463
published_at 2011-11
Creators : Itoh Michiko Suganami Takayoshi Nakagawa Nobutaka Tanaka Miyako Yamamoto Yukio Kamei Yasutomi Terai Shuji Sakaida Isao Ogawa Yoshihiko Publishers : American Association of Pathologists
山口医学 Volume 60 Issue 4 pp. 117 - 121
published_at 2011-08-31
Creators : Ooga Miho Hashimoto Shinichi Matsunaga Takeshi Tanabe Ryo Okamoto Takeshi Nishikawa Jun Shimizu Kensaku Higaki Shingo Fujimura Yoshihiko Nakamura Katsue Oga Atsunori Maeda Kazunari Hazama Shouichi Oka Masaaki Sakaida Isao Publishers : 山口大学医学会
山口医学 Volume 60 Issue 1-2 pp. 11 - 16
published_at 2011-04-30
Creators : Tanimoto Haruko Maeda Kazunari Nishikawa Jun Hashimoto Shinichi Suzuki Keiko Hamabe Koichi Saito Mari Kiyotoki Shu Okamoto Takeshi Watanabe Yusaku Tsutsui Masahito Hazama Shoichi Oka Masaaki Kawauchi Shigeto Sakaida Isao Publishers : 山口大学医学会
山口医学 Volume 60 Issue 1-2 pp. 5 - 10
published_at 2011-04-30
Creators : Nakamura Munetaka Nishikawa Jun Kiyotoki Shu Saito Mari Hamabe Koichi Okamoto Takeshi Yamasaki Takahiro Sakamoto Kazuhiko Oka Masaaki Gondo Toshikazu Sakaida Isao Publishers : 山口大学医学会
山口医学 Volume 59 Issue 4 pp. 183 - 188
published_at 2010-08-31
AA型アミロイドーシスを合併したCrohn病の一例を経験した.症例は73歳女性.発熱,下痢症状の改善がないため紹介入院となった.入院時の腹部単純X線写真では著明な大腸拡張像を認め,腹部骨盤CTでも回腸から結腸にかけての浮腫状の壁肥厚と腸管周囲に膿瘍の形成,回腸の拡張像を認めた.十二指腸粘膜の内視鏡下生検を施行したところ,組織学的にAA型アミロイドーシスと診断された.大腸内視鏡検査では異常所見はなかった.小腸X線二重造影検査にて,小腸の管状狭窄と拡張,潰瘍瘢痕,類円形の潰瘍が多発していた.AA型アミロイドーシスを合併したCrohn病の診断のもとに入院・加療を行った.絶食と抗生剤点滴で腸管安静をはかると下痢などの症状は改善し,食事を流動食から固形食に変えると症状の増悪を認めた.Crohn病は栄養療法で寛解導入され,その後維持された.消化管アミロイドーシスの消化器症候もなく4年間経過良好である.
Creators : Harima Yohei Hashimoto Kazuo Higaki Shingo Mitani Nobuyuki Gondo Toshikazu Sakaida Isao Publishers : 山口大学医学会
山口医学 Volume 58 Issue 3 pp. 111 - 116
published_at 2009-06-30
症例は46歳男性.近医の腹部エコーで膵尾部近傍に腫瘤を認めたため当科へ紹介された.腹部CTで小腸間膜根部に約50mm大の低吸収域の腫瘤性病変を認めた.腹部MRIではT1強調像で低信号,T2強調像で高信号の多房性腫瘍を認めた.悪性の可能性も否定できず,診断的意味も含め,外科的切除を施行した.腫瘍は表面平滑,弾性軟で,他の周囲臓器への癒着は認めなかった.腫瘍は組織学的に嚢胞状リンパ管腫と診断した.リンパ管腫は小児の頭頚部に好発する良性腫瘍であるが,成人の腸間膜に発生したリンパ管腫はまれであるため報告する.
Creators : Kiyotoki Shu Nishikawa Jun Fujiwara Keiko Saito Mari Hamabe Koichi Okamoto Takeshi Higaki Shingo Tokuhisa Yoshihiro Gondo Toshikazu Oka Masaaki Sakaida Isao Publishers : 山口大学医学会
山口医学 Volume 48 Issue 1 pp. 1 - 2
published_at 1999-02
Creators : Kayano Kozo Sakaida Isao Okita Kiwamu Publishers : 山口大学医学会
山口医学 Volume 35 Issue 1 pp. 17 - 22
published_at 1986-02
Creators : Nagasawa Toshiaki Kado Yuji Sakaida Isao Sanuki Kazutoshi Hino Keisuke Ogino Keiki Nawata Hiroshi Shingai Yasushi Yasunaga Mitsuru Ezaki Takarou Ando Keijirou Okita Kiwamu Takemoto Tadayoshi Publishers : 山口大学医学会
Creators : Iwano Hirotoshi Ryozawa Shomei Harano Megumi Iwamoto Sayaka Ishigaki Noriko Taba kumiko Sakaida Isao Publishers : Yamaguchi University School of Medicine
pp. 93 - 97
published_at 2008-10
Creators : Segawa Makoto 大森 薫 山口 裕樹 内田 耕一 是永 圭子 是永 匡紹 寺井 崇二 山崎 隆弘 坂井田 功 Publishers : 中外医学社
Hepatology research : the official journal of the Japan Society of Hepatology Volume 24 Issue 4 pp. 420 - 428
published_at 2002
Creators : Segawa Makoto Sakaida Isao Takeo Yoshifumi Harada Toshiya Yoshida Tomoharu Okita Kiwamu Publishers : Elsevier
Hepatology research : the official journal of the Japan Society of Hepatology Volume 24 Issue 3 pp. 305 - 315
published_at 2002
Creators : Segawa Makoto Kayano Kozo Sakaguchi Eiki Okamoto Mariko Sakaida Isao Okita Kiwamu Publishers : Elsevier
Creators : Sakaida Isao Publishers : Yamaguchi University Graduate School of Medicine
Clinical gastroenterology Volume 23 Issue 6 pp. 721 - 725
published_at 2008
Creators : Segawa Makoto Sakaida Isao Publishers : 日本メディカルセンター