Terai Shuji

Affiliate Master Yamaguchi University

Id (<span class="translation_missing" title="translation missing: en.view.desc">Desc</span>)
Application of cell therapy using stem cell into intractable diseases has been noted as the medicine in the next generation taking the place of organ transplantation. Bone marrow cells have been focused as a candidate of the source of this therapy. Liver failure is a terminal state of all advanced liver diseases and thousands of patients are dying of decompensated liver cirrhosis in every year in Japan. Liver transplantation must be the strongest weapon to relieve those patients. However, particularly in Japan, liver transplantation has not been popularized. In this sense, we thought of autologous bone marrow cells transplantation for decompensated liver cirrhosis. Basic studies using animal model revealed that transplanted bone marrow cells into syngenic mouse suffering from liver cirrhosis migrated into the damaged liver and transdifferentiated to the hepatocytes. Based upon the animal studies, clinical trial of this new cell therapy supported by the Ministry of Health, Labor and Welfare is ongoing. It is early to estimate this therapy. However, free from liver failure has been observed in some cases.
Creators : Okita Kiwamu Sakaida Isao Terai Shuji Yamamoto Naoki Omori Kaoru Ishikawa Tsuyoshi Aoyama Kouji Shinoda Koh Hamamoto Yoshihiko Publishers : Yamaguchi University School of Medicine
山口医学 Volume 64 Issue 2 pp. 145 - 152
published_at 2015-05-01
Duodenal varices(DV)are the most common of ectopic varices. Although bleeding from DV is rare, it is difficult to control bleeding and sometimes fatal. We have encountered four clinical cases of ruptured DV. Case 1:A man in his 80s presented with a history of partial gastrectomy with Billroth-II reconstruction and LC due to chronic hepatitis C. We performed single-balloon endoscopy and injected 67% N-butyl-2-cyanoacrylate(NBCA)for DV on the afferent loop with red plug. Case 2:A woman in her 40s with primary biliary cirrhosis complained of tarry stool and anemia. We performed endoscopic injection sclerotherapy(EIS)with 67% NBCA for spurting bleeding point in duodenum. Case 3:A man in his 50s with liver cirrhosis(LC)due to chronic hepatitis B complained of tarry stool. We performed endoscopic variceal ligation(EVL)and balloon-occluded retrograde transvenous obliteration(B-RTO)for DV. Case 4:A man in his 60s with alcoholic LC complained of tarry stool. We performed EIS with 67% NBCA for DV. We added EVL, clipping, and argon plasma coagulation after EIS to control bleeding. To control bleeding was achieved in all cases.
Creators : Sasaki Ryo Matsuda Takashi Aibe Yuki Nakashima Takao Shiratsuki Shogo Iwamoto Takuya Ishikawa Tsuyoshi Terai Shuji Sakaida Isao Publishers : 山口大学医学会
山口医学 Volume 64 Issue 1 pp. 53 - 57
published_at 2015-02-01
A 36-year-old man diagnosed with Charcot-Marie-Tooth(CMT)disease type 1B was treated in the department of neurology of this hospital. Due to a liver injury(AST 237IU/ml, ALT 496IU/ml)which occurred in November 200X, he was introduced to our department. As a result of scrutiny, we diagnosed him with chronic hepatitis C genotype 2a(HCV-RNA 5.4logIU/ml).He will be admitted to the hospital for Interferon(IFN)therapy in April next year. Although the mechanism is unknown, there are a few reports of peripheral neuropathy related to IFN therapy. Therefore, IFN therapy is generally unfavorable for patients with neuromuscular disorders. There are several IFN preparations used in Japan. IFN alfa associated peripheral neuropathy appears less than 0.1-5% of the time. While there is no report of peripheral neuropathy related to IFN beta, we performed IFN beta and Rivabirin combination therapy with a severe follow-up by a neurologist. We could accomplish treatment without the exacerbation of neurologic symptoms. He achieved sustained viral response. When IFN therapy was provided for chronic hepatitis B or chronic hepatitis C complicated with peripheral neuropathy, there is some possibility of performing antiviral therapy safely by using IFN beta.
山口医学 Volume 64 Issue 1 pp. 35 - 40
published_at 2015-02-01
Spontaneous rupture of hepatocellular carcinoma(HCC)is well known. However, rupture of HCC after transcatheter arterial chemoembolization(TACE)is a rare but potentially fatal complication. Herein, we report a case of ruptured HCC after TACE in a 73-year-old man with chronic liver injury(non-B and non-C).He had previously undergone subsegmental resection of S7 of the liver for HCC. One year later, multiple HCCs were detected. TACE was performed for the recurrent HCCs located on the surface of S2 of the liver. Epigastric pain and decreased blood pressure were observed after the treatment. Although his symptoms improved immediately, the patient gradually became anemic. Radiological examination after TACE revealed a hematoma around the S2 lesion. Therefore, we diagnosed rupture of HCC. We performed TAE and could control the bleeding. Few possible mechanisms of ruptured HCC after TACE include increasing pressure inside the tumor and capsular injury due to TACE. Consequently, HCC which has a high risk of rupture after TACE should be assured embolization and careful observation.
Creators : Fukui Yumi Saeki Issei Hanazono Tadasuke Tanabe Norikazu Urata Yohei Hidaka Isao Terai Shuji Sakaida Isao Publishers : 山口大学医学会
Tissue engineering. Part B, Reviews Volume 20 Issue 3 pp. 206 - 210
published_at 2014-06-01
Creators : Terai Shuji Takami Taro Yamamoto Naoki Fujisawa Koichi Ishikawa Tsuyoshi Urata Yohei Tanimoto Haruko Iwamoto Takuya Mizunaga Yuko Matsuda Takashi Oono Takashi Marumoto Miho Burganova Guzel R. Quintanilha Luiz Fernando Hidaka Isao Marumoto Yoshio Saeki Issei Uchida Koichi Yamasaki Takahiro Tani Kenji Taura Yasuho Fujii Yasuhiko Nishina Hiroshi Okita Kiwamu Sakaida Isao Publishers : Mary Ann Liebert
Hepato-Gastroenterology Volume 60 Issue 124 pp. 733 - 737
published_at 2013-06
Creators : Harima Satoko Hashimoto Shinichi Shibata Hiroaki Matsunaga Takaharu Tanabe Ryo Terai Shuji Sakaida Isao Publishers : Georg Thieme
The transactions of the Institute of Electrical Engineers of Japan. C, A publication of Electronics, Information and Systems Society Volume 133 Issue 2 pp. 289 - 296
published_at 2013
Creators : Hayashi Takaya Fujita Yusuke Mitani Yoshihiro Hamamoto Yoshihiko Segawa Makoto Terai Shuji Sakaida Isao Publishers : 電気学会
Biochemical and Biophysical Research Communications Volume 431 Issue 4 pp. 712 - 717
published_at 2013
Creators : Ichimura K. Kawashima Y. Nakamura T. Powell R. Hidoh Y. Terai S. Sakaida I. Kodera Y. Tsuji T. Ma J. X. Sakai T. Matsumoto H. Obara T. Publishers : University of Chicago Press
Disease models & mechanisms : DMM Volume 3 pp. 605 - 617
published_at 2010-09
Creators : Akada Junko K. Aoki Hiroki Torigoe Yuji Kitagawa Takao Kurazono Hisao Hoshida Hisashi Nishikawa Jun Terai Shuji Matsuzaki Masunori Hirayama Toshiya Nakazawa Teruko Akada Rinji Nakamura Kazuyuki Publishers : Company of Biologists
生化学 Volume 84 Issue 8 pp. 707 - 711
published_at 2012-08
Creators : 寺井 崇二 坂井田 功 Publishers : 日本生化学会
Gastroenterology Volume 54 Issue 6 pp. 690 - 693
published_at 2012-06
Creators : 寺井 崇二 Oono Takashi 在津 潤一 大石 俊之 桑代 紳哉 松本 俊彦 橋本 真一 岡本 健志 戒能 聖治 内田 耕一 坂井田 功 Publishers : 科学評論社
Discovery medicine Volume 14 Issue 74 pp. 7 - 12
published_at 2012-07-14
Creators : Takami Taro Terai Shuji Sakaida Isao Publishers : Discovery Medicine
Hepato-Gastroenterology : journal of clinical research and practice Volume 59 Issue 114 pp. 533 - 537
published_at 2012-03
Creators : Okita Kohsuke Yamasaki Takahiro Hamabe Satoe Saeki Issei Harima Yohei Terai Shuji Sakaida Isao Publishers : Georg Thieme
Journal of gastroenterology
published_at 2012-04-05
Creators : Terai Shuji Tanimoto Haruko Maeda Masaki Zaitsu Junichi Hisanaga Takuro Iwamoto Takuya Fujisawa Koichi Mizunaga Yuko Matsumoto Toshihiko Urata Yohei Marumoto Yoshio Hidaka Isao Ishikawa Tsuyoshi Yokoyama Yuichiro Aoyama Koji Tsuchiya Masako Takami Taro Omori Kaoru Yamamoto Naoki Segawa Makoto Uchida Koichi Yamasaki Takahiro Okita Kiwamu Sakaida Isao Publishers : Springer international | Springer-Verlag
Clinica chimica acta : international journal of clinical chemistry Volume 412 Issue 1-2 pp. 152 - 158
published_at 2011-01-14
Creators : Iizuka Norio Oka Masaaki Sakaida Isao Moribe Toyoki Miura Toshiaki Kimura Naoki Tamatsukuri Shigeru Ishitsuka Hideo Uchida Koichi Terai Shuji Yamashita Satoyoshi Okita Kiwamu Sakata Koichiro Karino Yoshiyasu Toyota Joji Ando Eiji Ide Tatsuya Sata Michio Tsunedomi Ryoichi Tsutsui Masahito Iida Michihisa Tokuhisa Yoshihiro Sakamoto Kazuhiko Tamesa Takao Fujita Yusuke Hamamoto Yoshihiko Publishers : Elsevier Science
Cell and tissue research Volume 344 Issue 1 pp. 125 - 134
published_at 2011-04
Creators : Kuwashiro Shinya Terai Shuji Oishi Toshiyuki Fujisawa Koichi Matsumoto Toshihiko Nishina Hiroshi Sakaida Isao Publishers : Springer
Biochemical and biophysical research communications Volume 414 Issue 2 pp. 331 - 336
published_at 2011-10-22
Biochemical and biophysical research communications Volume 408 Issue 1 pp. 120 - 125
published_at 2011-04-29
Creators : Miyamura Norio Nakamura Takashi Goto-Inoue Naoko Zaima Nobuhiro Hayasaka Takahiro Yamasaki Tokiwa Terai Shuji Sakaida Isao Setou Mitsutoshi Nishina Hiroshi Publishers : Academic Press
American journal of pathology Volume 179 Issue 5 pp. 2454 - 2463
published_at 2011-11
Creators : Itoh Michiko Suganami Takayoshi Nakagawa Nobutaka Tanaka Miyako Yamamoto Yukio Kamei Yasutomi Terai Shuji Sakaida Isao Ogawa Yoshihiko Publishers : American Association of Pathologists
pp. 93 - 97
published_at 2008-10
Creators : Segawa Makoto 大森 薫 山口 裕樹 内田 耕一 是永 圭子 是永 匡紹 寺井 崇二 山崎 隆弘 坂井田 功 Publishers : 中外医学社
Japanese journal of portal hypertension Volume 13 Issue 3 pp. 192 - 196
published_at 2007
Creators : Segawa Makoto Terai Shuji 吉田 智治 Sakaida Isao Publishers : 日本門脈圧亢進症学会
pp. 202 - 206
published_at 2008-10
Creators : Segawa Makoto 寺井 崇二 播磨 陽平 藤澤 浩一 佐伯 一成 桑代 紳哉 岩本 拓也 水永 裕子 松本 俊彦 仁科 惣治 Publishers : 中外医学社