山口県大学共同リポジトリ

Liquid biopsy test based on a sensitive dna methylation assay for diagnosing hepatocellular carcinoma : which is a better marker, methylated sst or sept9?

山口医学 Volume 70 Issue 3 pp. 89 - 98

published_at 2021-09-01

We performed this study to investigate whether serum cell-free DNA testing(liquid biopsy)of either methylated SEPT9 or methylated SST, which are possible biomarkers of HCC, in combination with AFP may improve clinical performance for the detection of HCC. Study subjects included 25 healthy controls, 15 patients with chronic liver disease without HCC, and 38 patients with HCC. Methylation level of serum cell-free SEPT9 and SST was measured by methylation-sensitive restriction enzymes followed by multiplex droplet digital polymerase chain reaction. According to receiver operating characteristic curve analysis to discriminate between non-HCC group(including control group and chronic liver disease without HCC group)and HCC group, area under the curve(AUC)was 0.73 by AFP and 0.73 by mSEPT9, whereas it was only 0.59 by mSST. Regarding combination tests, although negative predictive values were almost same between the AFP + mSEPT9 test and the AFP + mSST test(75.0% vs 72.2%),a positive predictive value of AFP + mSEPT9 test was higher than that of the AFP + mSST test(79.4% vs. 66.7%).In conclusions, methylated SEPT9 was a better companion marker of AFP for HCC screening than methylated SST.

Creators : Yamasaki Ayano Suehiro Yutaka Hoshida Tomomi Saeki Issei Yamauchi Kotoh Yurika Matsumoto Toshihiko Takami Taro Sakaida Isao Yamasaki Takahiro Publishers : 山口大学医学会

Diagnosis of α-thalassemia using droplet digital PCR

The bulletin of the Yamaguchi Medical School Volume 66 Issue 1-2 pp. 37 - 44

published_at 2019

Creators : Amao Yuki Yamashiro Yasuhiro Hattori Yukio Ogata Shizuka Ohto Fukumi Mella Ferania Kimoto Masafumi Mori Kentaro Suehiro Yutaka Yamasaki Takahiro Publishers : Yamaguchi University School of Medicine

Utility of real-time tissue elastography in the sequential evaluation of liver fibrosis in patients with chronic hepatitis C

The bulletin of the Yamaguchi Medical School Volume 66 Issue 1-2 pp. 29 - 35

published_at 2019

Creators : Hanazono Tadasuke Hidaka Isao Maeda Masaki Saeki Issei Iwamoto Takuya Ishikawa Tsuyoshi Takami Taro Yamasaki Takahiro Sakaida Isao Publishers : Yamaguchi University School of Medicine

Utility of contrast-enhanced ultrasonography for the evaluation of partial splenic embolization

The bulletin of the Yamaguchi Medical School Volume 66 Issue 1-2 pp. 7 - 13

published_at 2019

Creators : Fukui Yumi Saeki Issei Matsuda Takashi Maeda Masaki Hisanaga Takuro Iwamoto Takuya Matsumoto Toshihiko Hidaka Isao Ishikawa Tsuyoshi Takami Taro Yamasaki Takahiro Sakaida Isao Publishers : Yamaguchi University School of Medicine

Effectiveness of early intervention by specialized institutions for liver cirrhosis patients

山口医学 Volume 66 Issue 3 pp. 163 - 168

published_at 2017-08-01

Creators : Hisanaga Takuro Yamasaki Takahiro Maeda Masaki Iwamoto Takuya Saeki Issei Matsumoto Toshihiko Hidaka Isao Marumoto Yoshio Ishikawa Tsuyoshi Takami Taro Sakaida Isao Publishers : 山口大学医学会

From tracing the history of medical therapies to the development of novel therapies for hepatocellular carcinoma

山口医学 Volume 65 Issue 1 pp. 15 - 22

published_at 2016-02-01

Creators : Yamasaki Takahiro Publishers : 山口大学医学会

Adoptive immunotherapy with MUC1-mRNA transfected dendritic cells and cytotoxic lymphocytes plus gemcitabine for unresectable pancreatic cancer

Journal of Translational Medicine Volume 12 Issue 1 pp. 175 -

published_at 2014-06-19

Creators : Shindo Yoshitaro Hazama Shoichi Maeda Yoshinari Matsui Hiroto Iida Michihisa Suzuki Nobuaki Yoshimura Kiyoshi Ueno Tomio Yoshino Shigefumi Sakai Kohei Suehiro Yutaka Yamasaki Takahiro Hinoda Yuji Oka Masaaki Publishers : BioMed Central

Status and prospects of liver cirrhosis treatment by using bone marrow-derived cells and mesenchymal cells

Tissue engineering. Part B, Reviews Volume 20 Issue 3 pp. 206 - 210

published_at 2014-06-01

Creators : Terai Shuji Takami Taro Yamamoto Naoki Fujisawa Koichi Ishikawa Tsuyoshi Urata Yohei Tanimoto Haruko Iwamoto Takuya Mizunaga Yuko Matsuda Takashi Oono Takashi Marumoto Miho Burganova Guzel R. Quintanilha Luiz Fernando Hidaka Isao Marumoto Yoshio Saeki Issei Uchida Koichi Yamasaki Takahiro Tani Kenji Taura Yasuho Fujii Yasuhiko Nishina Hiroshi Okita Kiwamu Sakaida Isao Publishers : Mary Ann Liebert

Clinical characteristics of patients who developed hepatocellular carcinoma after hepatitis C virus eradication with interferon therapy : Current status in Japan

Internal Medicine Volume 52 Issue 24 pp. 2701 - 2706

published_at 2013

Creators : Sato Akira Sata Michio Ikeda Kenji Kumada Takashi Izumi Namiki Asahina Yasuhiro Osaki Yukio Chayama Kazuaki Kaneko Shuichi Sakai Akito Onji Morikazu Hiasa Yoichi Omura Takumi Ozeki Itaru Yokosuka Osamu Shiina Shuichiro Itsubo Mariko Nishiguchi Shuhei Hirano Katsuharu Ide Tatsuya Sakisaka Shotaro Yamasaki Takahiro Hidaka Isao Tanaka Masatoshi Kim Soo Ryang Ichida Takafumi Publishers : 日本内科学会

A case of primary hepatic neuroendocrine carcinoma clinically suggested

山口医学 Volume 63 Issue 1 pp. 53 - 60

published_at 2014-02-01

Creators : Kawasato Ryo Shiratsuki Shogo Iwamoto Takuya Saeki Issei Urata Yohei Hidaka Isao Ishikawa Tsuyoshi Takami Taro Uchida Kouichi Terai Shuji Yamasaki Takahiro Sakaida Isao Publishers : 山口大学医学会

Progression from non-alcoholic steatohepatitis(NASH)to decompensated liver cirrhosis during the course of crohn’s disease : a case report

山口医学 Volume 62 Issue 1 pp. 33 - 37

published_at 2013-02-01

Creators : Tanabe Norikazu Harima Yumiko Hashimoto Shinichi Terai Shuji Yamasaki Takahiro Sakaida Isao Publishers : 山口大学医学会

Granulocyte colony-stimulating factor and interleukin-1β are important cytokines in repair of the cirrhotic liver after bone marrow cell infusion: Comparison of humans and model mice

Cell transplantation Volume 21 Issue 11 pp. 2363 - 2375

published_at 2012

Creators : Mizunaga Yuko Terai Shuji Yamamoto Naoki Uchida Koichi Yamasaki Takahiro Nishina Hiroshi Fujita Yusuke Shinoda Koh Hamamoto Yoshihiko Sakaida Isao Publishers : Pergamon Press | Elsevier Science

Elaborate designs with artisan spirit to treat liver cancer in Japan

肝臓 Volume 53 Issue 8 pp. 463 - 485

published_at 2012

Creators : Tanaka Katsuaki Ikeda Kenji Yamasaki Takahiro Nagamatsu Hiroaki Ueshima Kazuomi Publishers : 日本肝臓学会

Evaluation of a novel non-invasive ^{13}C-glucose breath test for the identification of diabetes mellitus in cirrhotic patients

Hepatology research : the official journal of the Japan Society of Hepatology

published_at 2012-04-17

Creators : Tsuchiya Masako Yamasaki Takahiro Sakaida Isao Publishers : Elsevier | Elsevier Science Ireland

Complications of radiofrequency ablation for hepatocellular carcinoma in a multicenter study: An analysis of 16 346 treated nodules in 13 283 patients

Hepatology research : the official journal of the Japan Society of Hepatology

published_at 2012-04-10

Creators : Koda Masahiko Murawaki Yoshikazu Hirooka Yasuaki Kitamoto Mikiya Ono Masafumi Sakaeda Hiroshi Joko Kouji Sato Shuichi Tamaki Katsuyoshi Yamasaki Takahiro Shibata Hiroshi Shimoe Toshinari Matsuda Tadakazu Toshikuni Nobuyuki Fujioka Shin-ichi Ohmoto Kenji Nakamura Shinichiro Kariyama Kazuya Aikata Hiroshi Kobayashi Yoshiyuki Tsutsui Akemi Publishers : Elsevier | Elsevier Science Ireland

Hepatic arterial infusion chemotherapy in combination with pegylated interferon-α-2b for advanced hepatocellular carcinoma

Hepato-Gastroenterology : journal of clinical research and practice Volume 59 Issue 114 pp. 533 - 537

published_at 2012-03

Creators : Okita Kohsuke Yamasaki Takahiro Hamabe Satoe Saeki Issei Harima Yohei Terai Shuji Sakaida Isao Publishers : Georg Thieme

Timeline for development of autologous bone marrow infusion (ABMi) therapy and perspective for future stem cell therapy

Journal of gastroenterology

published_at 2012-04-05

Creators : Terai Shuji Tanimoto Haruko Maeda Masaki Zaitsu Junichi Hisanaga Takuro Iwamoto Takuya Fujisawa Koichi Mizunaga Yuko Matsumoto Toshihiko Urata Yohei Marumoto Yoshio Hidaka Isao Ishikawa Tsuyoshi Yokoyama Yuichiro Aoyama Koji Tsuchiya Masako Takami Taro Omori Kaoru Yamamoto Naoki Segawa Makoto Uchida Koichi Yamasaki Takahiro Okita Kiwamu Sakaida Isao Publishers : Springer international | Springer-Verlag

A case of neuroendcrine tumor of the ileum with liver metastases treated with transcatheter arterial chemoembolization with degradable starch microspheres and biotherapy with octreotide

山口医学 Volume 60 Issue 6 pp. 255 - 261

published_at 2011-12-31

Creators : Oono Takashi Segawa Makoto Hashimoto Shinichi Uchida Koichi Terai Shuji Yamasaki Takahiro Hoshii Yoshinobu Sakaida Isao Publishers : 山口大学医学会

A case of ruptured duodenal varices treated by combination therapy of endoscopic variceal ligation and balloon-occluded retrograde transvenous obliteration

山口医学 Volume 60 Issue 6 pp. 237 - 242

published_at 2011-12-31

Creators : Matsuda Takashi Ishikawa Tsuyoshi Suenaga Shigeyuki Goto Atsushi Hamabe Kouichi Iwamoto Takuya Hashimoto Shinichi Nakashima Yoshiteru Okada Munemasa Uchida Koichi Terai Shuji Yamasaki Takahiro Sakaida Isao Publishers : 山口大学医学会

Efficacy of novel transcatheter arterial therapy for hepatocellular carcinoma

山口医学 Volume 60 Issue 5 pp. 173 - 178

published_at 2011-10-31

Creators : Yamasaki Takahiro Publishers : 山口大学医学会

A case of duodenal carcinoma treated by surgery and adjuvant therapy with gemcitabine

山口医学 Volume 60 Issue 1-2 pp. 5 - 10

published_at 2011-04-30

Creators : Nakamura Munetaka Nishikawa Jun Kiyotoki Shu Saito Mari Hamabe Koichi Okamoto Takeshi Yamasaki Takahiro Sakamoto Kazuhiko Oka Masaaki Gondo Toshikazu Sakaida Isao Publishers : 山口大学医学会

A malignant stage IV lymphoma, suggesting primary hepatic lymphoma

山口医学 Volume 45 Issue 3 pp. 201 - 208

published_at 1996-06

Creators : Kubo Keiko Yamasaki Takahiro Yasunaga Mitsuru Okita Kiwamu Wada Takako Seguchi Masato Tsuruta Ryohei Murakami Fujio Tateishi Akio Maekawa Tsuyoshi Takahashi Mutsuo Publishers : 山口大学医学会

16. 当科における近年の薬物性肝障害の動向について

pp. 93 - 97

published_at 2008-10

Creators : Segawa Makoto 大森薫山口裕樹内田耕一是永圭子是永匡紹寺井崇二山崎隆弘坂井田功 Publishers : 中外医学社