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Sugahara Kazuma

Affiliate Master Yamaguchi University

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Medical Science & Innovation Volume 71 Issue 1-2 pp. 35 - 43
published_at 2024-06
This study investigated the potential of adalimumab (ADA), a monoclonal antibody targeting TNF-alfa, to protect the inner ear from intense sound exposure, given that inflammatory cytokines, including TNF-alfa, are linked to hearing loss in acoustic disorders. In this study, adalimumab was administered to mice, and its effect on the inner ear was assessed. We examined the translocation of ADA to the inner ear and its ototoxicity and impact on acoustic exposure. The results showed that adalimumab partially reached the cochlea after administration but increased the susceptibility to acoustic exposure, resulting in higher hair cell loss in the inner ear. While TNF-alfa had been considered a potential therapeutic target, the results suggested that excessive TNF-alfa suppression could harm the inner ear. We acknowledged some limitations, such as the use of adalimumab instead of an anti-mouse TNF-alfa antibody and the need to explore the suppression of other cytokines for better inner ear protection. In conclusion, adalimumab administration was found to increase the inner earʼs susceptibility to acoustic exposure, potentially leading to more significant hair cell damage, possibly due to excessive TNF-alfa suppression
Creators : 山本 陽平 Sugahara Kazuma Tsuda Junko Hashimoto Makoto Yamashita Hiroshi Publishers : Yamaguchi University School of Medicine
Medical Science & Innovation Volume 71 Issue 1-2 pp. 21 - 33
published_at 2024-06
Vestibular hair cells are susceptible to damage from various stimuli such as infections, ischemia, and certain therapeutic drugs, including aminoglycoside antibiotics and the antineoplastic agent cisplatin. In mammals, damage to the vestibular hair cells is permanent. This study aimed to evaluate the protective effects of nobiletin (NOB) against aminoglycoside-induced hair cell death using utricles collected from adult mice. The utricles removed from CBA/N mice were assigned to eight groups according to the dose of NOB and the administration or not of neomycin. Hair cells in the utricles were counted by double labeling with calmodulin and calbindin. NOB inhibited hair cell death in utricles exposed to neomycin. The protective effect of NOB on hair cells in the utricles was also suggested to have resulted from the inhibition of the production and accumulation of 4-hydroxy-2-nonenal, the final product of lipid peroxide aldehyde. NOB suppressed neomycin-induced hair cell death. The principle of hair cell protection from aminoglycoside-induced hair cell death suggests that NOB inhibits reactive oxygen species formation in the utricles exposed to neomycin.
Creators : Masaki Tatsuya Sugahara Kazuma Hashimoto Makoto Yamashita Hiroshi Publishers : Yamaguchi University School of Medicine
Medical Science & Innovation Volume 71 Issue 1-2 pp. 1 - 8
published_at 2024-06
Benign paroxysmal positional vertigo (BPPV) is the most common vertigo disease and is more likely to occur in perimenopausal women, suggesting an association with osteoporosis. Since otoconia are primarily composed of calcium carbonate, abnormal calcium metabolism may lead to otoconia dislocation. However, the detailed mechanism is currently unknown. In this study, we investigated the effects of drugs (cadmium and dexamethasone) that cause abnormal calcium metabolism on otolith formation in zebrafish larvae. Here, otolith size was clearly reduced in the cadmium group, and the calcium content of the larvae was also markedly reduced. In contrast, in the dexamethasone group, which also had a lower calcium content than the control group, otolith size increased. Our results suggest that, as in bone, calcium metabolism influences the repeated dissolution and recrystallization of otoliths and maintains homeostasis in response to calcium concentrations in the endolymphatic fluid.
Creators : Iwamoto Aya Sugahara Kazuma Hashimoto Makoto Yamashita Hiroshi Publishers : Yamaguchi University School of Medicine
耳鼻咽喉科免疫アレルギー Volume 33 Issue 3 pp. 201 - 204
published_at 2015-09
Creators : Sugahara Kazuma Yamashita Hiroshi Publishers : 日本耳鼻咽候科免疫アレルギー学会
山口医学 Volume 64 Issue 3 pp. 213 - 216
published_at 2015-08-01
Creators : Okinaka Yosuke Sugahara Kazuma Tsuda Junko Tanaka Kuniyoshi Kanagawa Eiju Shimogori Hiroaki Yamashita Hiroshi Publishers : 山口大学医学会
Practica otologica Kyoto Volume 106 Issue 6 pp. 505 - 508
published_at 2013
Creators : 下郡 博明 菅原 一真 山下 裕司 Publishers : 耳鼻咽喉科臨床会
Practica otologica Kyoto Volume 106 Issue 9 pp. 779 - 781
published_at 2013-09
Creators : Kano Yukari Shimogori Hiroaki Sugawara Kazuma Tarumoto Shunsuke Yamashita Hiroshi Publishers : 耳鼻咽喉科臨床会
Audiology Japan Volume 55 Issue 5 pp. 587 - 588
published_at 2012-09-30
Creators : 菅原 一真 Tsuda Junko 橋本 誠 金川 英寿 山下 裕司 Publishers : 日本オージオロジー学会
Audiology Japan Volume 55 Issue 5 pp. 563 - 564
published_at 2012-09-30
Creators : 金川 英寿 菅原 一真 広瀬 敬信 御厨 剛史 下郡 博明 山下 裕司 Publishers : 日本オージオロジー学会
Audiology Japan Volume 55 Issue 5 pp. 497 - 498
published_at 2012-09-30
Creators : 中津 愛子 橋本 誠 菅原 一真 下郡 博明 山下 裕司 Publishers : 日本オージオロジー学会
Audiology Japan Volume 55 Issue 5 pp. 403 - 404
published_at 2012-09-30
Creators : 橋本 誠 菅原 一真 山本 陽平 下郡 博明 山下 裕司 Publishers : 日本オージオロジー学会
Allergology & immunology Volume 19 Issue 8 pp. 1288 - 1294
published_at 2012-08
Creators : Mikuriya Takefumi Sugahara Kazuma Hashimoto Makoto Yamashita Hiroshi Publishers : 医薬ジャーナル社
Otolaryngology-head and neck surgery (Tokyo) Volume 84 Issue 8 pp. 541 - 544
published_at 2012-07
Creators : 菅原 一真 山下 裕司 Publishers : 医学書院
JOHNS : journal of Otolaryngology, Head & Neck Surgery Volume 28 Issue 5 pp. 803 - 805
published_at 2012-05
Creators : 菅原 一真 山下 裕司 Publishers : 東京医学社
耳鼻咽喉科展望 Volume 54 Issue 5 pp. 334 - 336
published_at 2011-10-15
Creators : Hashimoto Makoto Mikuriya Takefumi Sugahara Kazuma Yamashita Hiroshi Publishers : 東京慈恵会医科大学耳鼻咽喉科学教室
Audiology Japan Volume 54 Issue 5 pp. 609 - 610
published_at 2011-09-30
Creators : Tsuda Junko 菅原 一真 金川 英寿 御厨 剛史 山下 裕司 Publishers : 日本オージオロジー学会
Audiology Japan Volume 54 Issue 5 pp. 607 - 608
published_at 2011-09-30
Creators : 金川 英寿 菅原 一真 御厨 剛史 橋本 誠 下郡 博明 山下 裕司 Publishers : 日本オージオロジー学会
Audiology Japan Volume 54 Issue 5 pp. 603 - 604
published_at 2011-09-30
Creators : 御厨 剛史 菅原 一真 金川 英寿 Tsuda Junko 下郡 博明 山下 裕司 Publishers : 日本オージオロジー学会
Audiology Japan Volume 54 Issue 5 pp. 541 - 542
published_at 2011-09-30
Creators : 中津 愛子 橋本 誠 下郡 博明 菅原 一真 山下 裕司 池田 卓生 Publishers : 日本オージオロジー学会
Audiology Japan Volume 54 Issue 5 pp. 505 - 506
published_at 2011-09-30
Creators : 菅原 一真 橋本 誠 御厨 剛史 下郡 博明 山下 裕司 Publishers : 日本オージオロジー学会
山口医学 Volume 48 Issue 4 pp. 159 - 164
published_at 1999-08
Creators : Sugahara Kazuma Okinaka Yoshihiko Imate Yuji Shimogori Hiroaki Ogata Yoichi Noguchi Fumiko Fukui Kazuko Yamashita Hiroshi Fujinami Tomoyuki Hasegawa Toshifumi Publishers : 山口大学医学会
山口医学 Volume 48 Issue 3 pp. 103 - 108
published_at 1999-06
Creators : Shimogori Hiroaki Sugahara Kazuma Nakatsu Aiko Imamoto Michiyo Takahashi Masahiro Publishers : 山口大学医学会