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Sugahara Kazuma

Affiliate Master Yamaguchi University

Topical application of substance P facilitates vestibular functional recovery induced by AMPA in the guinea pig

The bulletin of the Yamaguchi Medical School Volume 58 Issue 3-4 Page 31-36
published_at 2011
A050058000302.pdf
[fulltext] 1.24 MB
Title
Topical application of substance P facilitates vestibular functional recovery induced by AMPA in the guinea pig
Creators Toyota Hideki
Creators Shimogori Hiroaki
Creators Sugahara Kazuma
Creators Yamashita Hiroshi
Source Identifiers
Creator Keywords
vestibular disease substance P vestibulo-ocular reflex AMPA
Hypothesis: Topical Substance P (SP) application facilitates recovery from vestibular disorders induced by (±)-α-amino-3-hydroxy-5-methyl-isoxazole-4-propionic acid (AMPA) in guinea pigs and may offer a treatment strategy for patients with peripheral vestibular disorders. Methods: Sixteen Hartley white guinea pigs were assigned to groups administered with SP and artificial perilymph. A hole was drilled adjacent to a round window and AMPA was infused into the hole to induce a vestibular disorder. Thereafter, SP or artificial perilymph was delivered via an osmotic pump inserted into the hole. We observed spontaneous nystagmus and measured vestibulo-ocular reflexes (VOR) gains using sinusoidal rotation tests. Results: Spontaneous nystagmus decreased immediately after SP infusion, and the gain ratios were significantly higher than those in the control group at 3 and 7 days after treatment. Conclusion: Topical SP application facilitates recovery from AMPA-induced vestibular disorders in guinea pigs.
Languages eng
Resource Type departmental bulletin paper
Publishers Yamaguchi University School of Medicine
Date Issued 2011
File Version Version of Record
Access Rights open access
Relations
[ISSN]0513-1812
[NCID]AA00594272
Schools 大学院医学系研究科(医学) 医学部附属病院