コンテンツメニュー

Hashimoto Makoto

Affiliate Master Yamaguchi University

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Medical Science & Innovation Volume 71 Issue 1-2 pp. 35 - 43
published_at 2024-06
This study investigated the potential of adalimumab (ADA), a monoclonal antibody targeting TNF-alfa, to protect the inner ear from intense sound exposure, given that inflammatory cytokines, including TNF-alfa, are linked to hearing loss in acoustic disorders. In this study, adalimumab was administered to mice, and its effect on the inner ear was assessed. We examined the translocation of ADA to the inner ear and its ototoxicity and impact on acoustic exposure. The results showed that adalimumab partially reached the cochlea after administration but increased the susceptibility to acoustic exposure, resulting in higher hair cell loss in the inner ear. While TNF-alfa had been considered a potential therapeutic target, the results suggested that excessive TNF-alfa suppression could harm the inner ear. We acknowledged some limitations, such as the use of adalimumab instead of an anti-mouse TNF-alfa antibody and the need to explore the suppression of other cytokines for better inner ear protection. In conclusion, adalimumab administration was found to increase the inner earʼs susceptibility to acoustic exposure, potentially leading to more significant hair cell damage, possibly due to excessive TNF-alfa suppression
Creators : 山本 陽平 Sugahara Kazuma Tsuda Junko Hashimoto Makoto Yamashita Hiroshi Publishers : Yamaguchi University School of Medicine
Medical Science & Innovation Volume 71 Issue 1-2 pp. 21 - 33
published_at 2024-06
Vestibular hair cells are susceptible to damage from various stimuli such as infections, ischemia, and certain therapeutic drugs, including aminoglycoside antibiotics and the antineoplastic agent cisplatin. In mammals, damage to the vestibular hair cells is permanent. This study aimed to evaluate the protective effects of nobiletin (NOB) against aminoglycoside-induced hair cell death using utricles collected from adult mice. The utricles removed from CBA/N mice were assigned to eight groups according to the dose of NOB and the administration or not of neomycin. Hair cells in the utricles were counted by double labeling with calmodulin and calbindin. NOB inhibited hair cell death in utricles exposed to neomycin. The protective effect of NOB on hair cells in the utricles was also suggested to have resulted from the inhibition of the production and accumulation of 4-hydroxy-2-nonenal, the final product of lipid peroxide aldehyde. NOB suppressed neomycin-induced hair cell death. The principle of hair cell protection from aminoglycoside-induced hair cell death suggests that NOB inhibits reactive oxygen species formation in the utricles exposed to neomycin.
Creators : Masaki Tatsuya Sugahara Kazuma Hashimoto Makoto Yamashita Hiroshi Publishers : Yamaguchi University School of Medicine
Medical Science & Innovation Volume 71 Issue 1-2 pp. 1 - 8
published_at 2024-06
Benign paroxysmal positional vertigo (BPPV) is the most common vertigo disease and is more likely to occur in perimenopausal women, suggesting an association with osteoporosis. Since otoconia are primarily composed of calcium carbonate, abnormal calcium metabolism may lead to otoconia dislocation. However, the detailed mechanism is currently unknown. In this study, we investigated the effects of drugs (cadmium and dexamethasone) that cause abnormal calcium metabolism on otolith formation in zebrafish larvae. Here, otolith size was clearly reduced in the cadmium group, and the calcium content of the larvae was also markedly reduced. In contrast, in the dexamethasone group, which also had a lower calcium content than the control group, otolith size increased. Our results suggest that, as in bone, calcium metabolism influences the repeated dissolution and recrystallization of otoliths and maintains homeostasis in response to calcium concentrations in the endolymphatic fluid.
Creators : Iwamoto Aya Sugahara Kazuma Hashimoto Makoto Yamashita Hiroshi Publishers : Yamaguchi University School of Medicine
Oto-rhino-laryngology Tokyo Volume 56 Issue 5 pp. 308 - 310
published_at 2014-10
Creators : Hara Hirotaka Hashimoto Makoto Yamashita Hiroshi Publishers : 耳鼻咽喉科展望会
Oto-rhino-laryngology Tokyo Volume 56 Issue 5 pp. 306 - 307
published_at 2014-10
Creators : Hashimoto Makoto Yamamoto Yohei Hara Hirotaka Yamashita Hiroshi Publishers : 耳鼻咽喉科展望会
Oto-rhino-laryngology Tokyo Volume 55 Issue 5 pp. 337 - 339
published_at 2012-10-15
Creators : 橋本 誠 御厨 剛史 山本 陽平 山下 裕司 Publishers : 耳鼻咽喉科展望会
The journal of Japan Rhinologic Society Volume 51 Issue 2 pp. 93 - 101
published_at 2012
Creators : Mikuriya Takefumi Hashimoto Makoto Takeno Kenji Yamashita Hiroshi Publishers : 日本鼻科学会
Audiology Japan Volume 55 Issue 5 pp. 587 - 588
published_at 2012-09-30
Creators : 菅原 一真 Tsuda Junko 橋本 誠 金川 英寿 山下 裕司 Publishers : 日本オージオロジー学会
Audiology Japan Volume 55 Issue 5 pp. 497 - 498
published_at 2012-09-30
Creators : 中津 愛子 橋本 誠 菅原 一真 下郡 博明 山下 裕司 Publishers : 日本オージオロジー学会
Audiology Japan Volume 55 Issue 5 pp. 403 - 404
published_at 2012-09-30
Creators : 橋本 誠 菅原 一真 山本 陽平 下郡 博明 山下 裕司 Publishers : 日本オージオロジー学会
Allergology & immunology Volume 19 Issue 8 pp. 1288 - 1294
published_at 2012-08
Creators : Mikuriya Takefumi Sugahara Kazuma Hashimoto Makoto Yamashita Hiroshi Publishers : 医薬ジャーナル社
Practica Oto-Rhino-Laryngologica Volume 105 Issue 7 pp. 603 - 612
published_at 2012-07
Creators : Hashimoto Makoto Yamashita Hiroshi Publishers : 耳鼻咽喉科臨床学会
耳鼻咽喉科展望 Volume 54 Issue 5 pp. 334 - 336
published_at 2011-10-15
Creators : Hashimoto Makoto Mikuriya Takefumi Sugahara Kazuma Yamashita Hiroshi Publishers : 東京慈恵会医科大学耳鼻咽喉科学教室
耳鼻咽喉科展望 Volume 54 Issue 5 pp. 330 - 333
published_at 2011-10-15
Creators : 原 浩貴 豊田 英樹 橋本 誠 山下 裕司 Publishers : 東京慈恵会医科大学耳鼻咽喉科学教室
Audiology Japan Volume 54 Issue 5 pp. 607 - 608
published_at 2011-09-30
Creators : 金川 英寿 菅原 一真 御厨 剛史 橋本 誠 下郡 博明 山下 裕司 Publishers : 日本オージオロジー学会
Audiology Japan Volume 54 Issue 5 pp. 541 - 542
published_at 2011-09-30
Creators : 中津 愛子 橋本 誠 下郡 博明 菅原 一真 山下 裕司 池田 卓生 Publishers : 日本オージオロジー学会
Audiology Japan Volume 54 Issue 5 pp. 505 - 506
published_at 2011-09-30
Creators : 菅原 一真 橋本 誠 御厨 剛史 下郡 博明 山下 裕司 Publishers : 日本オージオロジー学会