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山本 陽平

Affiliate Master Yamaguchi University

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Medical Science & Innovation Volume 71 Issue 1-2 pp. 35 - 43
published_at 2024-06
This study investigated the potential of adalimumab (ADA), a monoclonal antibody targeting TNF-alfa, to protect the inner ear from intense sound exposure, given that inflammatory cytokines, including TNF-alfa, are linked to hearing loss in acoustic disorders. In this study, adalimumab was administered to mice, and its effect on the inner ear was assessed. We examined the translocation of ADA to the inner ear and its ototoxicity and impact on acoustic exposure. The results showed that adalimumab partially reached the cochlea after administration but increased the susceptibility to acoustic exposure, resulting in higher hair cell loss in the inner ear. While TNF-alfa had been considered a potential therapeutic target, the results suggested that excessive TNF-alfa suppression could harm the inner ear. We acknowledged some limitations, such as the use of adalimumab instead of an anti-mouse TNF-alfa antibody and the need to explore the suppression of other cytokines for better inner ear protection. In conclusion, adalimumab administration was found to increase the inner earʼs susceptibility to acoustic exposure, potentially leading to more significant hair cell damage, possibly due to excessive TNF-alfa suppression
Creators : 山本 陽平 Sugahara Kazuma Tsuda Junko Hashimoto Makoto Yamashita Hiroshi Publishers : Yamaguchi University School of Medicine
Audiology Japan Volume 55 Issue 5 pp. 403 - 404
published_at 2012-09-30
Creators : 橋本 誠 菅原 一真 山本 陽平 下郡 博明 山下 裕司 Publishers : 日本オージオロジー学会