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Tsuda Junko

Affiliate Master Yamaguchi University

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Medical Science & Innovation Volume 71 Issue 1-2 pp. 35 - 43
published_at 2024-06
This study investigated the potential of adalimumab (ADA), a monoclonal antibody targeting TNF-alfa, to protect the inner ear from intense sound exposure, given that inflammatory cytokines, including TNF-alfa, are linked to hearing loss in acoustic disorders. In this study, adalimumab was administered to mice, and its effect on the inner ear was assessed. We examined the translocation of ADA to the inner ear and its ototoxicity and impact on acoustic exposure. The results showed that adalimumab partially reached the cochlea after administration but increased the susceptibility to acoustic exposure, resulting in higher hair cell loss in the inner ear. While TNF-alfa had been considered a potential therapeutic target, the results suggested that excessive TNF-alfa suppression could harm the inner ear. We acknowledged some limitations, such as the use of adalimumab instead of an anti-mouse TNF-alfa antibody and the need to explore the suppression of other cytokines for better inner ear protection. In conclusion, adalimumab administration was found to increase the inner earʼs susceptibility to acoustic exposure, potentially leading to more significant hair cell damage, possibly due to excessive TNF-alfa suppression
Creators : 山本 陽平 Sugahara Kazuma Tsuda Junko Hashimoto Makoto Yamashita Hiroshi Publishers : Yamaguchi University School of Medicine
山口医学 Volume 64 Issue 3 pp. 213 - 216
published_at 2015-08-01
Creators : Okinaka Yosuke Sugahara Kazuma Tsuda Junko Tanaka Kuniyoshi Kanagawa Eiju Shimogori Hiroaki Yamashita Hiroshi Publishers : 山口大学医学会
Audiology Japan Volume 55 Issue 5 pp. 587 - 588
published_at 2012-09-30
Creators : 菅原 一真 Tsuda Junko 橋本 誠 金川 英寿 山下 裕司 Publishers : 日本オージオロジー学会
Audiology Japan Volume 54 Issue 5 pp. 609 - 610
published_at 2011-09-30
Creators : Tsuda Junko 菅原 一真 金川 英寿 御厨 剛史 山下 裕司 Publishers : 日本オージオロジー学会
Audiology Japan Volume 54 Issue 5 pp. 603 - 604
published_at 2011-09-30
Creators : 御厨 剛史 菅原 一真 金川 英寿 Tsuda Junko 下郡 博明 山下 裕司 Publishers : 日本オージオロジー学会