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Creators : Bando Tomoko Publishers : 山口大学教育学部 Date Issued : 2013-01-31
E.Spranger's gedanken über einheitsschule und die politische position
Bulletin of the Faculty of Education, Yamaguchi University Volume 62 Issue 1
Creators : Nishimura Masato Publishers : 山口大学教育学部 Date Issued : 2013-01-31
On the characteristic standpoint of Chu-Then-Pian (俶真篇)'s thought
Bulletin of the Faculty of Education, Yamaguchi University Volume 62 Issue 1
Creators : Nambu Hidehiko Publishers : 山口大学教育学部 Date Issued : 2013-01-31
The function of the final particle ”Tomo” in modern Japanese
Bulletin of the Faculty of Education, Yamaguchi University Volume 62 Issue 1
Creators : Nakano Nobuhiko Publishers : 山口大学教育学部 Date Issued : 2013-01-31
Interest in sake among university students in Yamaguchi
Bulletin of the Faculty of Education, Yamaguchi University Volume 62 Issue 1
Creators : Goto Yoshiko | Ishida Kanae | Ono Yusuke | Hirotsu Rie | Maeda Ayako | Murao Nami | Kashiwagi Susumu Publishers : 山口大学教育学部 Date Issued : 2013-01-31
Varieties and characteristics of fish and shellfish dishes in Yamaguchi Prefecture
Bulletin of the Faculty of Education, Yamaguchi University Volume 62 Issue 1
Creators : Goto Yoshiko | Ando Mami | Koda Tomoko | Sakurai Nahoko | Takao Chikako | Ikeda Hiroko | Yamamoto Yumi | Hanai Reiko Publishers : 山口大学教育学部 Date Issued : 2013-01-31
Advances of field research for the Pygmies by Europeans in 1880s-1890s
Bulletin of the Faculty of Education, Yamaguchi University Volume 62 Issue 1
Creators : Kitanishi Koichi Publishers : 山口大学教育学部 Date Issued : 2013-01-31
Creators : Arimoto Mitsuhiko Publishers : 山口大学教育学部 Date Issued : 2013-01-31
Food chains of Japanese-style confection stores : Traditional food manufacturing in today's supply system
Bulletin of the Faculty of Education, Yamaguchi University Volume 62 Issue 1
Creators : Araki Hitoshi Publishers : 山口大学教育学部 Date Issued : 2013-01-31
Creators : Abe Arata Publishers : 山口大学教育学部 Date Issued : 2013-01-31
Creators : Nakano Hiroyuki | Mano Takamitsu | Mishima Katsuaki | Kishi Masami | Horinaga Daijyu | Miyawaki Yuichiro | Mori Yoshihide | Ueyama Yoshiya Publishers : Yamaguchi University School of Medicine Date Issued : 2012
Creators : Yamashiro Yasuhiro | Hattori Yukio | Nitta Takenori | Adhiyanto Chris | Matar Maryam M. | Ferania Mella | Takagi Fumiya Publishers : Yamaguchi University School of Medicine Date Issued : 2012
Melatonin protects oocyte from reactive oxygen species
The bulletin of the Yamaguchi Medical School Volume 59 Issue 3-4
Creators : Tamura Hiroshi | Takasaki Akihisa | Taketani Toshiaki | Tanabe Manabu  | Kizuka Fumie | Lee Lifa | Tamura Isao | Maekawa Ryo | Aasada Hiromi | Yamagata Yoshiaki | Sugino Norihiro Publishers : Yamaguchi University School of Medicine Date Issued : 2012
Focal brain cooling: revisiting a potential therapeutic option for intractable epilepsy
The bulletin of the Yamaguchi Medical School Volume 59 Issue 3-4
Creators : Fujii Masami Publishers : Yamaguchi University School of Medicine Date Issued : 2012
Creators : Fujita Motoki | Maekawa Tsuyoshi | Todani Masaki | Tsuruta Ryosuke Publishers : Yamaguchi University School of Medicine Date Issued : 2012
Catecholaminergic polymorphic ventricular tachycardia (CPVT) is an inherited disease characterized by stress- or exercise- induced ventricular tachycardia, frequently leading to sudden cardiac death. A considerable body of evidence accumulated over recent years suggests that mutation-linked cardiac ryanodine receptor (RyR2) defects cause Ca^2+ leak from sarcoplasmic reticulum, which triggers delayed afterdepolarization and leads to CPVT. However, the underlying mechanism, by which a single mutation in such a large molecule causes drastic effects on the channel function, remains elusive. Here we report that introduction of a human CPVT mutation S2246L into the mouse RyR2 induces aberrant activation of channel gating by forming abnormally tight domain-domain interaction between the S2246L mutable domain and the K201-binding domain. This produces more global conformational change in the RyR2: namely, an aberrant domain unzipping between the N-terminal (a.a. 1–600) domain and the central (a.a. 2000–2500) domain owing to the allosteric conformational coupling mechanism. Pharmacological correction of the defective inter-domain interactions can stop the aberrant Ca^2+ release and lethal arrhythmia. These results provide a new pathogenic mechanism of CPVT and a novel therapeutic strategy against CPVT
Creators : Suetomi Takeshi | Yano Masafumi | Matsuzaki Masanori Publishers : Yamaguchi University School of Medicine Date Issued : 2012
Creators : Nagahata Minoru Publishers : 山口大学大学教育機構 Date Issued : 2012-03
Creators : Nakamizo Tomoko | Sakai Mieko | Kanamori Yumi Publishers : 山口大学大学教育機構 Date Issued : 2012-03
Creators : Tian Mei Publishers : 山口大学大学教育機構 Date Issued : 2012-03
Creators : Nagai Ryoko Publishers : 山口大学大学教育機構 Date Issued : 2012-03
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