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Focal brain cooling: revisiting a potential therapeutic option for intractable epilepsy
The bulletin of the Yamaguchi Medical School Volume 59 Issue 3-4
Creators : Fujii Masami Publishers : Yamaguchi University School of Medicine Date Issued : 2012
Creators : Fujita Motoki | Maekawa Tsuyoshi | Todani Masaki | Tsuruta Ryosuke Publishers : Yamaguchi University School of Medicine Date Issued : 2012
Catecholaminergic polymorphic ventricular tachycardia (CPVT) is an inherited disease characterized by stress- or exercise- induced ventricular tachycardia, frequently leading to sudden cardiac death. A considerable body of evidence accumulated over recent years suggests that mutation-linked cardiac ryanodine receptor (RyR2) defects cause Ca^2+ leak from sarcoplasmic reticulum, which triggers delayed afterdepolarization and leads to CPVT. However, the underlying mechanism, by which a single mutation in such a large molecule causes drastic effects on the channel function, remains elusive. Here we report that introduction of a human CPVT mutation S2246L into the mouse RyR2 induces aberrant activation of channel gating by forming abnormally tight domain-domain interaction between the S2246L mutable domain and the K201-binding domain. This produces more global conformational change in the RyR2: namely, an aberrant domain unzipping between the N-terminal (a.a. 1–600) domain and the central (a.a. 2000–2500) domain owing to the allosteric conformational coupling mechanism. Pharmacological correction of the defective inter-domain interactions can stop the aberrant Ca^2+ release and lethal arrhythmia. These results provide a new pathogenic mechanism of CPVT and a novel therapeutic strategy against CPVT
Creators : Suetomi Takeshi | Yano Masafumi | Matsuzaki Masanori Publishers : Yamaguchi University School of Medicine Date Issued : 2012
Some aspects of heat stress on the plasticity of skeletal muscle cells
The journal of physical fitness and sports medicine : JPFSM Volume 1 Issue 2
Creators : Goto Katsumasa | Ohno Yoshitaka | Goto Ayumi | Ikuta Akihiro | Suzuki Miho | Ohira Tomotaka | Tsuchiya Noriko | Nishizawa Sono | Koya Tomoyuki | Egawa Tatsuro | Sugiura Takao | Ohira Yoshinobu | Yoshioka Toshitada Publishers : Japanese Society of Physical Fitness and Sports Medicine Date Issued : 2012-08-22
Creators : Nakashima Yutaka | Fukuda Yoshiharu | Harada Masanori | Nakamori Yoshiaki Publishers : 日本プライマリ・ケア連合学会 Date Issued : 2012
A starting method of the harmonic current compensator using a hybrid active filter for wind power generation systems with soft starters
IEEJ transactions on electrical and electronic engineering : official journal of the Institute of Electrical Engineering of Japan Volume 7 Issue SUPPL. 1
Creators : Yamada Hiroaki | Hiraki Eiji | Tanaka Toshihiko Publishers : John Wiley & Sons, Inc Date Issued : 2012-12-21
Verbal control robot which interprets vague expression
Transactions of the Japan Society of Mechanical Engineers. C Volume 77 Issue 775
Creators : Ariki Ryo | Wada Kenzo | Fujii Fumitake Publishers : 日本機械学会 Date Issued : 2011-03-25
Direct measurement of wall-shear stress of plane shear layer with plasma synthetic jet actuator
Transactions of the Japan Society of Mechanical Engineers. B Volume 77 Issue 777
Creators : Higuchi Takehiro | Ogawara Kakuji | Mochizuki Shinsuke Publishers : 日本機械学会 Date Issued : 2011-05-25
Compression and recovery property for metal gasket with straight sections and arc sections
Transactions of the Japan Society of Mechanical Engineers. A Volume 77 Issue 782
Creators : Chen Dai-Heng | Karatsu Kouji | Masuda Kenichi | Haruyama Shigeyuki Publishers : 日本機械学会 Date Issued : 2011-10-25
Creators : Noda Shohei | Hyodo Masayuki | Furukawa Satoshi | Furui Toshihiko Publishers : 日本地震工学会 Date Issued : 2012-11-07
Separation of molybdenum and vanadium using two stage process of solvent extraction and stripping precipitation
Journal of MMIJ : journal of the Mining and Materials Processing Institute of Japan Volume 128 Issue 12
Creators : Niinae Masakazu | 鈴木 祐麻 | 藤 亜季子 | 松永 菜々恵 | 芝田 隼次 Publishers : 資源・素材学会 Date Issued : 2012-11-25
Creators : Hiratsuka Atsushi | Smizu Akihiko | Ueyama Takeshi | Doi Masahiro | Yoshida Masaaki | Fukuda Masakazu | Kato Takayoshi | Fumimoto Tomoko | Matsuzaki Masunori Publishers : 日本心臓ペーシング・電気生理学会 Date Issued : 2011
Nippon storm study design
Journal of arrhythmia Volume 28 Issue 5
Creators : Kurita Takashi | Noda Takashi | Nitta Takashi | Furushima Hiroshi | Shimizu Akihiko | Ohe Tohru | Aizawa Yoshifusa | Chiba Yasutaka Publishers : 日本心臓ペーシング・電気生理学会 Date Issued : 2012-10
Creators : Sasaki Hiromi | Ichikawa Yasuaki | Sakata Yoshimi | Endo Yasuyuki | Nishigaki Kazuo | Matsumoto Kotaro | Inokuma Hisashi Publishers : Elsevier Date Issued : 2012-12
Variability regions for certain families of harmonic univalent mappings
Complex variables and elliptic equations : an international journal Volume 58 Issue 1
Creators : Ponnusamy S. | Yamamoto H. | Yanagihara H. Publishers : Taylor & Francis Date Issued : 2013-01
Creators : Yamaguchi Masaya | Matoba Kazuaki | Sawada Ryoko | Fujioka Yuko | Nakatogawa Hitoshi | Yamamoto Hayashi | Kobashigawa Yoshihiro | Hoshida Hisashi | Akada Rinji | Ohsumi Yoshinori | Noda Nobuo N. | Inagaki Fuyuhiko Publishers : Nature Pub. Group Date Issued : 2012-12
Combustion of gaseous and liquid fuels in meso-scale tubes with wire mesh
Proceedings of the Combustion Institute Volume 34 Issue 2
Creators : Mikami Masato | Maeda Yoshiyuki | Matsui Keiichiro | Seo Takehiko | Yuliati Lilis Publishers : Combustion Institute Date Issued : 2013
Creators : Ishino Yoko | Harada Takanori Publishers : Scientific World Inc Date Issued : 2012
Creators : Sugimoto Kazutaka | Ideguchi Makoto | Sadahiro Hirokazu | Yoshikawa Koichi | Goto Hisaharu | Nomura Sadahiro | Fujii Masami | Suzuki Michiyasu Publishers : Springer-Verlag Tokyo Date Issued : 2013-01-11
Creators : Tani Seiji | Nakagawa Kenta | Honda Takuya | Saito Hiromasa | Suzuki Yasutaka | Kawamata Jun | Uchida Makiyo | Sasaki Akira | Kinjo Masataka Publishers : Bentham Science Publishers Date Issued : 2012-11-01
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