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Creators : Kuwahata Yoichiro Publishers : 山口大学人文学部異文化交流研究施設 Date Issued : 2024-03-31
What is a word?
Journal of cross-cultural studies Volume 18
Creators : Phillips John D. Publishers : 山口大学人文学部異文化交流研究施設 Date Issued : 2024-03-31
Creators : Abe Yasuki Publishers : 山口大学人文学部異文化交流研究施設 Date Issued : 2024-03-31
表紙・目次ほか
Journal of cross-cultural studies Volume 18
Publishers : 山口大学人文学部異文化交流研究施設 Date Issued : 2024-03-31
ロシアによるウクライナ戦争 : 言語の関係を考える(第40回公演会)
Cross-cultural interchange & research institute newsletter Volume 23
Creators : De Boissieu Michel Publishers : Yamaguchi University Faculty of Humanities Cross-cultural interchange & research institute Date Issued : 2023-08-01
山口にやってきて
Cross-cultural interchange & research institute newsletter Volume 23
Creators : 曾 力 Publishers : Yamaguchi University Faculty of Humanities Cross-cultural interchange & research institute Date Issued : 2023-08-01
アメリカ留学体験記
Cross-cultural interchange & research institute newsletter Volume 23
Creators : 濱田 美乃里 Publishers : Yamaguchi University Faculty of Humanities Cross-cultural interchange & research institute Date Issued : 2023-08-01
いつも「波待ち」 : 不確実性の時代を生きる客家華僑
Cross-cultural interchange & research institute newsletter Volume 23
Creators : Kobayashi Hiroshi Publishers : Yamaguchi University Faculty of Humanities Cross-cultural interchange & research institute Date Issued : 2023-08-01
新型コロナウィルス感染症拡大からみえてきたこと
Cross-cultural interchange & research institute newsletter Volume 23
Creators : Yokota Naotoshi Publishers : Yamaguchi University Faculty of Humanities Cross-cultural interchange & research institute Date Issued : 2023-08-01
巻頭言・目次ほか
Bulletin of Yamaguchi Science Research Center Volume 4
Publishers : 山口大学山口学研究センター Date Issued : 2024-07-31
Creators : Yamamoto Haruhiko | Koba Anna Publishers : 山口大学山口学研究センター Date Issued : 2024-07-31
Creators : Yamamoto Haruhiko | Koba Anna Publishers : 山口大学山口学研究センター Date Issued : 2024-07-31
Creators : Yamamoto Haruhiko | Koba Anna Publishers : 山口大学山口学研究センター Date Issued : 2024-07-31
Creators : Yamamoto Shugo | Suwa Tatsuo | Kato Shinya Publishers : 山口大学山口学研究センター Date Issued : 2024-07-31
Creators : Nabeyama Shoko Publishers : 山口大学山口学研究センター Date Issued : 2024-07-31
Creators : Seino Ryosuke | Tomari Shingo | Hatada Kaho | Fukushima Narumi | Yuasa Hina | Nakai Mina | Ueda Masumi Publishers : 山口大学山口学研究センター Date Issued : 2024-07-31
Creators : Hamahashi Mari | Fukui Seiji | Izuho Toshiro | Morishige Yasunobu Publishers : 山口大学山口学研究センター Date Issued : 2024-07-31
Creators : Nakano Yoshihisa | Nagashima Mariko | Hirakawa Kazuaki | Morifuku Yoji Publishers : 山口大学山口学研究センター Date Issued : 2024-07-31
Creators : Uehara Kazuaki | Bana Ryoji Publishers : 山口大学山口学研究センター Date Issued : 2024-07-31
This study investigated the potential of adalimumab (ADA), a monoclonal antibody targeting TNF-alfa, to protect the inner ear from intense sound exposure, given that inflammatory cytokines, including TNF-alfa, are linked to hearing loss in acoustic disorders. In this study, adalimumab was administered to mice, and its effect on the inner ear was assessed. We examined the translocation of ADA to the inner ear and its ototoxicity and impact on acoustic exposure. The results showed that adalimumab partially reached the cochlea after administration but increased the susceptibility to acoustic exposure, resulting in higher hair cell loss in the inner ear. While TNF-alfa had been considered a potential therapeutic target, the results suggested that excessive TNF-alfa suppression could harm the inner ear. We acknowledged some limitations, such as the use of adalimumab instead of an anti-mouse TNF-alfa antibody and the need to explore the suppression of other cytokines for better inner ear protection. In conclusion, adalimumab administration was found to increase the inner earʼs susceptibility to acoustic exposure, potentially leading to more significant hair cell damage, possibly due to excessive TNF-alfa suppression
Creators : 山本 陽平 | Sugahara Kazuma | Tsuda Junko | Hashimoto Makoto | Yamashita Hiroshi Publishers : Yamaguchi University School of Medicine Date Issued : 2024-06
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