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Severe Fever with Thrombocytopenia Syndrome Initially Diagnosed as Diffuse Large B-cell lymphoma

Medical Science & Innovation Volume 72 Issue 1-2

A 70-year-old woman presented with acute fever, impaired consciousness, leukopenia, thrombocytopenia, and right inguinal lymphadenopathy. A lymph node biopsy was diagnosed as diffuse large B-cell lymphoma (DLBCL). However, her symptoms were consistent with severe fever with thrombocytopenia syndrome (SFTS), and RT-PCR for SFTS virus (SFTSV) RNA was positive. The patient’s condition and lymphadenopathy gradually improved with supportive measures and short-term steroid treatment and no lymphadenopathy recurrence was observed. Lymph node pathological examination revealed SFTSV-infected cells, leading to the final diagnosis of necrotizing lymphadenitis associated with SFTS. Careful consideration is required to differentiate necrotizing lymphadenitis associated with SFTS from that associated with DLBCL.

An invited review following the Soujinkai Award: Human Induced Pluripotent Stem Cell Modeling of the Blood-Brain Barrier Identifies Intrinsic Barrier Dysfunction in Multiple Sclerosis

Medical Science & Innovation Volume 72 Issue 1-2

Blood-brain barrier (BBB) dysfunction found in the multiple sclerosis (MS) cases is generally considered as a consequence of neuroinflammation. In this study we challenge this view by developing and analyzing novel BBB model from MS patients using induced pluripotent stem cells (iPSCs). We differentiated iPSCs into brain microvascular endothelial cell (BMEC)-like cells to establish an in vitro BBB model. We found that BMEC-like cells from MS patients exhibited compromised barrier integrity, characterized by weakened junctions, heightened permeability, and an elevated inflammatory profile when compared to cells from healthy individuals. Notably, the activation of the Wnt/β-catenin signaling pathway led to improvements in barrier function and a reduction in inflammatory responses, indicating potential therapeutic targets for reinforcing BBB stability in MS.

Creators : Nishihara Hideaki Publishers : Yamaguchi University School of Medicine Date Issued : 2025-06

An Invited Review following the Soujinkai Young Investigator Award: Modulating Calmodulin-Ryanodine Receptor Binding as a Strategy to Halt Pressure-Overload Induced Cardiac Hypertrophy

Medical Science & Innovation Volume 72 Issue 1-2

Cardiac hypertrophy is widely recognized as a significant risk factor contributing to adverse outcomes in individuals with cardiovascular conditions. The disruption of intracellular calcium ( Ca^{2+} ) balance has been implicated in the development of cardiac hypertrophy, though the precise mechanisms remain poorly understood. In this research, we explored whether hypertrophy induced by pressure overload may arise from the destabilization of the cardiac ryanodine receptor (RyR2) triggered by the dissociation of calmodulin (CaM), leading to subsequent Ca^{2+} leakage. We also assessed whether genetically strengthening the binding affinity between CaM and RyR2 could potentially reverse this process. In the early phases of cardiac hypertrophy caused by pressure overload—when contractile function is still intact—we observed that RyR2 destabilization mediated by reactive oxygen species (ROS) coincides with impaired relaxation. Moreover, stabilizing RyR2 through enhanced CaM binding was found to completely inhibit hypertrophic signaling and improve survival rates. Our findings reveal a crucial connection between RyR2 destabilization and the progression of cardiac hypertrophy.

Creators : Kohno Michiaki | Kobayashi Shigeki | Yamamoto Takeshi | Yano Masafumi Publishers : Yamaguchi University School of Medicine Date Issued : 2025-06

How local skate spots are created : A Case Study of Ishin Hyakunen Kinen Koen

The journal of Yamaguchi area studies Volume 20

Creators : Kuwahata Yoichiro Publishers : The association for Yamaguchi area studies Date Issued : 2023-03-31

Practical Cooperation and Collaboration between Community-based Care Hospital Nurses and Home-Visiting Nurses to Support Elderly People with Dementia Returning Home

Yamaguchi medical journal Volume 72 Issue 3

Creators : Kiyonaga Asako | Nagata Chizuru Publishers : Yamaguchi University medical association Date Issued : 2023-09-01

Current Status and Issues of University Career Guidance at Support Schools

The journal of Yamaguchi area studies Volume 20

Creators : Hayashi Hiroko Publishers : The association for Yamaguchi area studies Date Issued : 2023-03-31

Liquid Biopsy Test Based on a Sensitive DNA Methylation Assay for Diagnosing Early-Stage Hepatocellular Carcinoma: Which Is Better as a Combination Marker of AFP and PIVKA-II, Methylated SEPT9 or HOXA1?

Yamaguchi medical journal Volume 72 Issue 3

Cover, Table of Contents, etc.

The journal of Yamaguchi area studies Volume 20

Publishers : The association for Yamaguchi area studies Date Issued : 2023-03-31

Upstream Processes in Cell Manufacturing for Regenerative Medicine

Yamaguchi medical journal Volume 72 Issue 2

Creators : Nagai Hiroyuki | Takami Taro Publishers : Yamaguchi University medical association Date Issued : 2023-05-29

An Adult Case of Jejunal Mesenteric Lymphangioma Treated by Laparoscopic Assisted Surgery

Yamaguchi medical journal Volume 72 Issue 2

Creators : Ikeshita Takahiro | Kuga Takayuki | Shigeta Masatoshi | Yano Yuka Publishers : Yamaguchi University medical association Date Issued : 2023-05-29

Trend of the On-line Self Assessment about Attainment Targets in Clinical Clerkship in 3 Years

Yamaguchi medical journal Volume 72 Issue 2

Creators : Hisanaga Takuro | Takeuchi Yuriko | Nishimoto Arata | Katsura Shunsaku | Shirasawa Bungo Publishers : Yamaguchi University medical association Date Issued : 2023-05-29

A Case of Mucinous Carcinoma of the Pancreas with Duodenal Invasion

Yamaguchi medical journal Volume 72 Issue 1

Effective Continuing Education to Enhance Perceived Nursing Competence by Operating Room Nurses: Analyses of Open-ended Questionnaire Data Utilizing Text-mining

Yamaguchi medical journal Volume 72 Issue 1

Creators : Miyamoto Izumi | Yamase Hiroaki | Tado Asami Publishers : Yamaguchi University medical association Date Issued : 2023-02-28

Mental and Physical Responses to Viewing Nostalgic Showa-era Video in Older People with Dementia and Care Staffs

Yamaguchi medical journal Volume 72 Issue 1

The Report of Regular Meeting

The journal of Yamaguchi area studies Volume 19

Publishers : The association for Yamaguchi area studies Date Issued : 2022-03-31

The Sociology of “Suzuki Hiroshi” Part 1 : Overview of Suzuki Sociology from the Viewpoint of the Sociological Laboratory, Faculty of Letters, Kyushu University Ⅱ

The journal of Yamaguchi area studies Volume 19

Creators : Miura Noriko Publishers : The association for Yamaguchi area studies Date Issued : 2022-03-31

Appendix 2 Tree species identification of wooden relics at Yosida site in the 2012 fiscal year

Yamaguchi University Archaeological Museum report Volume 19

Creators : (株)吉田生物研究所 Publishers : Yamaguchi University Archaeological Museum Date Issued : 2025-03-31

Current Status and Issues of Correspondence High Schools in Yamaguchi Prefecture

The journal of Yamaguchi area studies Volume 19

Creators : Hayashi Hiroko Publishers : The association for Yamaguchi area studies Date Issued : 2022-03-31

Appendix 1 Wooden relics from buried river at Yosida site

Yamaguchi University Archaeological Museum report Volume 19

Creators : Yokoyama Shigeki Publishers : Yamaguchi University Archaeological Museum Date Issued : 2025-03-31

Chapter II The project on the Yamaguchi University campus in the 2021 fiscal year - Appendix 2 List of researches in Yamaguchi University campus

Yamaguchi University Archaeological Museum report Volume 19

Publishers : Yamaguchi University Archaeological Museum Date Issued : 2025-03-31