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- 大学院医学系研究科(医学)
大学院医学系研究科(医学)
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山口医学 Volume 64 Issue 3
pp. 177 - 181
published_at 2015-08-01
山口医学 Volume 64 Issue 2
pp. 79 - 85
published_at 2015-05-01
山口医学 Volume 64 Issue 2
pp. 145 - 152
published_at 2015-05-01
Duodenal varices(DV)are the most common of ectopic varices. Although bleeding from DV is rare, it is difficult to control bleeding and sometimes fatal. We have encountered four clinical cases of ruptured DV. Case 1:A man in his 80s presented with a history of partial gastrectomy with Billroth-II reconstruction and LC due to chronic hepatitis C. We performed single-balloon endoscopy and injected 67% N-butyl-2-cyanoacrylate(NBCA)for DV on the afferent loop with red plug. Case 2:A woman in her 40s with primary biliary cirrhosis complained of tarry stool and anemia. We performed endoscopic injection sclerotherapy(EIS)with 67% NBCA for spurting bleeding point in duodenum. Case 3:A man in his 50s with liver cirrhosis(LC)due to chronic hepatitis B complained of tarry stool. We performed endoscopic variceal ligation(EVL)and balloon-occluded retrograde transvenous obliteration(B-RTO)for DV. Case 4:A man in his 60s with alcoholic LC complained of tarry stool. We performed EIS with 67% NBCA for DV. We added EVL, clipping, and argon plasma coagulation after EIS to control bleeding. To control bleeding was achieved in all cases.
Creators :
Sasaki Ryo
Matsuda Takashi
Aibe Yuki
Nakashima Takao
Shiratsuki Shogo
Iwamoto Takuya
Ishikawa Tsuyoshi
Terai Shuji
Sakaida Isao
Publishers : 山口大学医学会
山口医学 Volume 64 Issue 1
pp. 53 - 57
published_at 2015-02-01
A 36-year-old man diagnosed with Charcot-Marie-Tooth(CMT)disease type 1B was treated in the department of neurology of this hospital. Due to a liver injury(AST 237IU/ml, ALT 496IU/ml)which occurred in November 200X, he was introduced to our department. As a result of scrutiny, we diagnosed him with chronic hepatitis C genotype 2a(HCV-RNA 5.4logIU/ml).He will be admitted to the hospital for Interferon(IFN)therapy in April next year. Although the mechanism is unknown, there are a few reports of peripheral neuropathy related to IFN therapy. Therefore, IFN therapy is generally unfavorable for patients with neuromuscular disorders. There are several IFN preparations used in Japan. IFN alfa associated peripheral neuropathy appears less than 0.1-5% of the time. While there is no report of peripheral neuropathy related to IFN beta, we performed IFN beta and Rivabirin combination therapy with a severe follow-up by a neurologist. We could accomplish treatment without the exacerbation of neurologic symptoms. He achieved sustained viral response. When IFN therapy was provided for chronic hepatitis B or chronic hepatitis C complicated with peripheral neuropathy, there is some possibility of performing antiviral therapy safely by using IFN beta.
Creators :
Matsuura Keiji
Hidaka Isao
Hanazono Tadasuke
Saeki Issei
Iwamoto Takuya
Ishikawa Tsuyoshi
Takami Taro
Kawai Motoharu
Terai Shuji
Takashi Takashi
Sakaida Isao
Publishers : 山口大学医学会
山口医学 Volume 64 Issue 1
pp. 35 - 40
published_at 2015-02-01
Spontaneous rupture of hepatocellular carcinoma(HCC)is well known. However, rupture of HCC after transcatheter arterial chemoembolization(TACE)is a rare but potentially fatal complication. Herein, we report a case of ruptured HCC after TACE in a 73-year-old man with chronic liver injury(non-B and non-C).He had previously undergone subsegmental resection of S7 of the liver for HCC. One year later, multiple HCCs were detected. TACE was performed for the recurrent HCCs located on the surface of S2 of the liver. Epigastric pain and decreased blood pressure were observed after the treatment. Although his symptoms improved immediately, the patient gradually became anemic. Radiological examination after TACE revealed a hematoma around the S2 lesion. Therefore, we diagnosed rupture of HCC. We performed TAE and could control the bleeding. Few possible mechanisms of ruptured HCC after TACE include increasing pressure inside the tumor and capsular injury due to TACE. Consequently, HCC which has a high risk of rupture after TACE should be assured embolization and careful observation.
Creators :
Fukui Yumi
Saeki Issei
Hanazono Tadasuke
Tanabe Norikazu
Urata Yohei
Hidaka Isao
Terai Shuji
Sakaida Isao
Publishers : 山口大学医学会
The bulletin of the Yamaguchi Medical School Volume 57 Issue 3-4
pp. 33 - 40
published_at 2010
Creators :
Suenaga Hiromi
Sakaida Isao
Korenaga Keiko
Okamoto Takeshi
Segawa Makoto
Uchida Kouichi
Hinoda Yuji
Publishers : Yamaguchi University School of Medicine
山口医学 Volume 66 Issue 1
pp. 5 - 10
published_at 2017-02-01
Creators :
Nagata Chizuru
Publishers : 山口大学医学会
The bulletin of the Yamaguchi Medical School Volume 64 Issue 1-2
pp. 1 - 12
published_at 2017
Aberrant increases in protein phosphatase 1(PP1) activity have been shown to be associated with inefficient sarcoplasmic reticulum Ca^{2+} cycling, leading to cardiac dysfunction in the failing heart. In the present study, we investigated whether BNP promoter-inducible suppression of PP1β would ameliorate progression of pressure overload-induced heart failure in mice, a clinically relevant animal model. An Adeno-associated virus 9 (AAV9) vector encoding PP1βshRNA and a negative control (NC) shRNA driven by a brain natriuretic peptide (BNP) promoter with an emerald green fluorescent protein expression (EmGFP) cassette were used to test the hypothesis. AAV9 vectors (AAV9-BNP-EmGFP-PP1βshRNA and AAV9-BNP-EmGFP-NCshRNA) were introduced into the in vivo heart via the tail vein injection (4x10^{11} GC/mice) in 8-week-old C57BL6J mice, followed by transverse aortic constriction (TAC) 2 weeks after the AAV9 vector injection. Post TAC cardiac function was sequentially assessed every 2 week by echocardiography, followed by hemodynamic assessment at 1 month. AAV9-BNP-EmGFP-PP1βshRNA treatment suppressed myocardial PP1β expression by 15% compared with the NCshRNA group (p<0.001). The fractional shortening (%FS) of the left ventricle in the PP1βshRNA-treated group was significantly larger than the NCshRNA-treated group (21%±1.0% vs. 15%±0.01, p<0.01). The ratios of heart weight (HW) / body weight (BW) and lung weight (LW) / BW in the PP1βshRNA group were significantly smaller than those of the NCshRNA group (HW/BW: 9.20±0.49 vs. 10.6±0.45 mg/g
Creators :
Shiraishi Kozo
Ikeda Yasuhiro
Miyazaki Yosuke
Fujimoto Shizuka N.
Yoshimura Koichi
Miura Toshiro
Matsuzaki Masanori
Yano Masafumi
Publishers : Yamaguchi University School of Medicine
The bulletin of the Yamaguchi Medical School Volume 64 Issue 3-4
pp. 21 - 26
published_at 2017
Creators :
Kanchiku Tsukasa
Suzuki Hidenori
Imajo Yasuaki
Moriya Atsushi
Suetomi Yutaka
Nishida Norihiro
Funaba Masahiro
Takahashi Youhei
Taguchi Toshihiko
Publishers : Yamaguchi University School of Medicine
Investigative ophthalmology & visual science : journal of clinical and basic research Volume 49 Issue 11
pp. 4850 - 4857
published_at 2008
Journal of religion and health Volume 39 Issue 4
pp. 339 - 354
published_at 2000-12
The bulletin of the Yamaguchi Medical School Volume 59 Issue 3-4
pp. 25 - 29
published_at 2012
Catecholaminergic polymorphic ventricular tachycardia (CPVT) is an inherited disease characterized by stress- or exercise- induced ventricular tachycardia, frequently leading to sudden cardiac death. A considerable body of evidence accumulated over recent years suggests that mutation-linked cardiac ryanodine receptor (RyR2) defects cause Ca^2+ leak from sarcoplasmic reticulum, which triggers delayed afterdepolarization and leads to CPVT. However, the underlying mechanism, by which a single mutation in such a large molecule causes drastic effects on the channel function, remains elusive. Here we report that introduction of a human CPVT mutation S2246L into the mouse RyR2 induces aberrant activation of channel gating by forming abnormally tight domain-domain interaction between the S2246L mutable domain and the K201-binding domain. This produces more global conformational change in the RyR2: namely, an aberrant domain unzipping between the N-terminal (a.a. 1–600) domain and the central (a.a. 2000–2500) domain owing to the allosteric conformational coupling mechanism. Pharmacological correction of the defective inter-domain interactions can stop the aberrant Ca^2+ release and lethal arrhythmia. These results provide a new pathogenic mechanism of CPVT and a novel therapeutic strategy against CPVT
Creators :
Suetomi Takeshi
Yano Masafumi
Matsuzaki Masanori
Publishers : Yamaguchi University School of Medicine
The bulletin of the Yamaguchi Medical School Volume 63 Issue 1-2
pp. 25 - 34
published_at 2016
Background: Angiotensin II (AngII) increases reactive oxygen species (ROS) and induces glomerular sclerosis. Toll-like receptor 4 (TLR4)-mediated inflammation enhances the renal impairment in renal inflammatory diseases. The relationship between TLR4 and AngII-induced glomerular sclerosis is unknown.Methods: Mice lacking TLR4 function (Tlr4^{lps-d}) and wild-type (WT) mice were randomized into groups treated with AngII, norepinephrine (NE) or a sub-depressor dose of the AngII receptor blocker irbesartan along with AngII for 2 weeks. We then assessed the expressions of NADPH oxidase and monocyte chemoattractant protein-1 (MCP-1) and the inflammatory cell recruitment in the glomeruli. We also evaluated the mesangial matrix proliferation and ROS.Results: AngII and NE equally increased the systolic blood pressure compared to the control mice (p<0.05). In the WT mice treated with AngII, we observed glomerular sclerosis, an increase in NADPH oxidase, MCP-1 and the infiltration of macrophages as well as ROS content in the glomeruli compared to the control mice (p<0.05), whereas the Tlr4^{lps-d} mice showed little effects of AngII on these indices. In addition, the sub-depressor-dose irbesartan treatment reversed these changes. NE had little effects on these indices. Conclusions: TLR4 plays an important role in AngII-induced oxidative stress, inflammation and glomerular sclerosis through the AT1 receptor.
Creators :
Okamoto Tadashi
Umemoto Seiji
Yoshimura Koichi
Sakumura Toshihiro
Murata Tomoaki
Fukai Tohru
Yano Masafumi
Matsuzaki Masanori
Publishers : Yamaguchi University School of Medicine
The bulletin of the Yamaguchi Medical School Volume 63 Issue 1-2
pp. 5 - 16
published_at 2016
We investigated the relationship between myocardial oxidative stress and cardiac sympathetic hyperactivity in patients with takotsubo cardiomyopathy (TC) compared with acute anteroseptal myocardial infarction (AMI). Methods: In 10 TC patients and 10 AMI patients, electrocardiogram, echocardiography, cardiac catheterization were conducted, and plasma catecholamines and urinary (U) 8-hydroxy-2’-deoxyguanosine (8-OHdG) as a marker of oxidative DNA damage were taken for one week from onset. Results: On admission, the coronary sinus (CS) had significantly higher norepinephrine (NE) and 8-OHdG levels than the aortic root (Ao) and peripheral blood vessels. Circulating catecholamines in TC patients tended to be higher than those in AMI patients
Creators :
Oda Seiko
Kobayashi Shigeki
Nanno Takuma
Ishiguchi Hironori
Myoren Takeki
Murakami Wakako
Mochizuki Mamoru
Oda Tetsuro
Okuda Shinichi
Yamada Jutaro
Okamura Takayuki
Matsuzaki Masanori
Yano Masafumi
Publishers : Yamaguchi University School of Medicine
山口医学 Volume 66 Issue 2
pp. 89 - 96
published_at 2017-05-01
Background The lipid-lowering therapy by statins may stabilize and reduce coronary plaques. We compare the effect of strong or moderate statins on the coronary plaque characteristics by using 64-slice multidetector computed tomography (MDCT). Methods and Results We analyzed 13 subjects with non-calcified coronary plaques(NCP)as determined by MDCT. Pitavastatin(PTV:2mg/day)or pravastatin(PRA:10mg/day)were randomly administered. MDCT were performed at 0, 6 and 12 months after lipid-lowering therapy. In PTV group(n=6),CT density of NCP increased by 35.6 ± 28.8 HU after 6 months(p=0.037)and by 30.6 ± 29.8 HU after 12 months(NS).NCP area was decreased by 35.9 ± 15.2 % after 6 months and by 41.0 ± 16.5 % after 12 months(both P=0.001).In PRA group(n=7),CT density of NCP did not significantly increased after 6 months(NS)and after 12 months(NS).NCP area was not significantly decreased at 6 months(NS),but decreased by 23.1 ± 16.7 % at 12 months(P=0.001). Conclusions Serial CT angiography revealed that the regression of NCP occurs rapidly by strong lipid lowering therapy compared to the moderate statin therapy.
Creators :
Nao Tomoko
Miura Toshiro
Yoshimura Masayuki
Fujimura Tatsuhiro
Nakashima Yoshiteru
Okada Munemasa
Matsunaga Naofumi
Yano Masafumi
Publishers : 山口大学医学会
耳鼻咽喉科免疫アレルギー Volume 33 Issue 3
pp. 201 - 204
published_at 2015-09
FEBS letters Volume 587 Issue 21
pp. 3541 - 3547
published_at 2013-11-01
Creators :
Prakasama Ramachandran
Fujimoto Mitsuaki
Takii Ryosuke
Hayashida Naoki
Takaki Eiichi
Tan Ke
Wu Fangxu
Inouye Sachiyo
Nakai Akira
Publishers : Federation of European Biochemical Societies
Bioscience, biotechnology, and biochemistry Volume 79 Issue 4
pp. 587 - 597
published_at 2015
Creators :
Nga Bui Thi To
Luziga Claudius
Yamamoto Misa
Kusakabe Ken Takeshi
Yamamoto Yoshimi
Publishers : 日本農芸化学会
The bulletin of the Yamaguchi Medical School Volume 65 Issue 1-2
pp. 11 - 20
published_at 2018
Creators :
Mahbub MH
Hase Ryosuke
Yamaguchi Natsu
Takahashi Hidekazu
Kawano Yoshinao
Hiroshige Keiichi
Tanabe Tsuyoshi
Harada Noriaki
Publishers : Yamaguchi University School of Medicine
The bulletin of the Yamaguchi Medical School Volume 65 Issue 3-4
pp. 27 - 35
published_at 2018
Creators :
Nishimura Takashi
Okamura Takayuki
Tateishi Hiroki
Fujimura Tatsuhiro
Oda Tetsuro
Wada Yasuaki
Okuda Shinichi
Omuro Ayumi
Maeda Takako
Hamada Yoriomi
Nanno Takuma
Fukui Go
Yamada Jutaro
Yano Masafumi
Publishers : Yamaguchi University School of Medicine
山口医学 Volume 67 Issue 4
pp. 187 - 192
published_at 2018-12-28
山口医学 Volume 68 Issue 1
pp. 39 - 46
published_at 2019-03-01
Creators :
Nakamura Takashi
Sakano Hisashi
Kudo Junichi
Matsumoto Masaharu
Nakamura Munetaka
Yoneshiro Shigeru
Kuga Takayuki
Itoh Hiroshi
Hamano Kimikazu
Publishers : 山口大学医学会
The bulletin of the Yamaguchi Medical School Volume 66 Issue 1-2
pp. 1 - 6
published_at 2019
Creators :
Kato Takayoshi
Yamamoto Takeshi
Kobayashi Shigeki
Yano Masafumi
Publishers : Yamaguchi University School of Medicine
The bulletin of the Yamaguchi Medical School Volume 66 Issue 3-4
pp. 45 - 51
published_at 2019
Creators :
Ozaki Masakazu
Kouda Kyoji
Furukawa Hiroyuki
Kitahara Takashi
Publishers : Yamaguchi University School of Medicine
山口医学 Volume 66 Issue 2
pp. 135 - 138
published_at 2017-05-01
Nature communications Volume 6
pp. 6580 -
published_at 2015-03-12
Creators :
Tan Ke
Fujimoto Mitsuaki
Takii Ryosuke
Takaki Eiichi
Hayashida Naoki
Nakai Akira
Publishers : Nature Publishing Group
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
published_at 2012-05-23
Creators :
Yoneda Hiroshi
Shirao Satoshi
Koizumi Hiroyasu
Oka Fumiaki
Ishihara Hideyuki
Kunitsugu Ichiro
Kitahara Tetsuhiro
Iida Hidehiro
Suzuki Michiyasu
Publishers : Raven Press
A time and motion study of public health nurses’daily routine : Work breakdown and skill development
山口医学 Volume 66 Issue 1
pp. 17 - 24
published_at 2017-02-01
山口医学 Volume 66 Issue 1
pp. 41 - 45
published_at 2017-02-01
Creators :
Sasaki Sho
Nishikawa Jun
Nagao Misato
Ogawa Ryo
Goto Atsushi
Hashimoto Shinichi
Okamoto Takeshi
Suzuki Chieko
Hoshii Yoshinobu
Sakaida Isao
Publishers : 山口大学医学会
BMC Research Notes Volume 7
pp. 354 -
published_at 2014-06-10
Creators :
Fujita Takeshi
Tanabe Masahiro
Iida Etsushi
Matsunaga Naofumi
Ito Katsuyoshi
Publishers : Biomed Central
Journal of cardiology. Japanese edition Volume 7 Issue 2
pp. 152 - 158
published_at 2012-06
Creators :
Kobayashi Shigeki
Susa Takehisa
Murakami Wakako
Okuda Shinichi
Doi Masahiro
Wada Yasuaki
Nao Tomoko
Yamada Jutaro
Ueyama Tsuyoshi
Okamura Takayuki
Yano Masafumi
Matsuzaki Masunori
Publishers : 日本心臓病学会
Urology Volume 83 Issue 1
pp. 100 - 106
published_at 2014-01
International journal of urology Volume 19 Issue 11
pp. 994 - 994
published_at 2012-11-01
Journal of andrology Volume 33 Issue 6
pp. 1387 - 1393
published_at 2012-11
Creators :
Shiraishi Koji
Oka Shintaro
Ito Hideaki
Matsuyama Hideyasu
Publishers : J.B. Lippincott Co. | American Society of Andrology
International journal of urology Volume 19 Issue 6
pp. 538 - 550
published_at 2012-06
Creators :
Shiraishi Koji
Matsuyama Hideyasu
Takihara Hiroshi
Publishers : Churchill Livingstone Japan 社団法人日本泌尿器科学会 | Blackwell Science Asia
Journal of Ovarian Research Volume 7 Issue 1
pp. 10 -
published_at 2014-01-21
Creators :
Kizuka-Shibuya Fumie
Tokuda Nobuko
Takagi Kiyoshi
Adachi Yasuhiro
Lee Lifa
Tamura Isao
Maekawa Ryo
Tamura Hiroshi
Suzuki Takashi
Owada Yuji
Sugino Norihiro
Publishers : BioMed Central
Clinica chimica acta : international journal of clinical chemistry Volume 412 Issue 1-2
pp. 152 - 158
published_at 2011-01-14
Creators :
Iizuka Norio
Oka Masaaki
Sakaida Isao
Moribe Toyoki
Miura Toshiaki
Kimura Naoki
Tamatsukuri Shigeru
Ishitsuka Hideo
Uchida Koichi
Terai Shuji
Yamashita Satoyoshi
Okita Kiwamu
Sakata Koichiro
Karino Yoshiyasu
Toyota Joji
Ando Eiji
Ide Tatsuya
Sata Michio
Tsunedomi Ryoichi
Tsutsui Masahito
Iida Michihisa
Tokuhisa Yoshihiro
Sakamoto Kazuhiko
Tamesa Takao
Fujita Yusuke
Hamamoto Yoshihiko
Publishers : Elsevier Science
International journal of clinical oncology Volume 18 Issue 1
pp. 62 - 67
published_at 2013-02
Creators :
Shimabukuro Tomoyuki
Sakano Shigeru
Matsuda Kenji
Kamiryo Yoriaki
Yamamoto Norio
Kaneda Yoshitaka
Nasu Takahito
Baba Yoshikazu
Suga Akinobu
Yamamoto Mitsutaka
Aoki Akihiko
Takai Kimio
Yoshihiro Satoru
Konishi Motohiko
Imoto Katsuhiko
Matsuyama Hideyasu
Publishers : Churchill Livingstone | Springer
Cell and tissue research Volume 344 Issue 1
pp. 125 - 134
published_at 2011-04
Creators :
Kuwashiro Shinya
Terai Shuji
Oishi Toshiyuki
Fujisawa Koichi
Matsumoto Toshihiko
Nishina Hiroshi
Sakaida Isao
Publishers : Springer
Allergology international : official journal of the Japanese Society of Allergology Volume 60 Issue 3
pp. 355 - 363
published_at 2011
The journal of the Japan Surgical Association Volume 73 Issue 6
pp. 1465 - 1471
published_at 2012-06-25
Clinical nuclear medicine Volume 36 Issue 5
pp. 382 - 385
published_at 2011-03
Creators :
Suga Kazuyoshi
Matsunaga Naofumi
Kawakami Yasuhiko
Seki Norihiro
Kataoka Hideo
Taguchi Toshihiko
Publishers : Lippincott Williams & Wilkins
The Journal of the Japanese Society of Internal Medicine Volume 102 Issue 2
pp. 325 - 334
published_at 2013-02-10
日本外科学会雑誌 Volume 113 Issue 臨時増刊号2
pp. 599 - 599
published_at 2012-03-05
Clinical Chemistry and Laboratory Medicine Volume 51 Issue 4
pp. 781 - 789
published_at 2013-04
Clinical and Translational Gastroenterology Volume 5
pp. e48 -
published_at 2014-02-06
Creators :
Onishi Yoshihiro
Wakita Takafumi
Fukuhara Shinichi
Noguchi Yoshinori
Okada Mitsuru
Sakaida Isao
Sasaki Yutaka
Kobayashi Kenji
Publishers : American College of Gastroenterology
Hepatology research : the official journal of the Japan Society of Hepatology Volume 44 Issue 1
pp. 83 - 91
published_at 2014-01
Creators :
Okita Kiwamu
Kawazoe Seiji
Hasebe Chitomi
Kajimura Kozo
Kaneko Akira
Okada Mitsuru
Sakaida Isao
ASCITES Dose-Finding Trial Group
Publishers : Elsevier | The Japan Society of Hepatology
Journal of International Medical Research Volume 41 Issue 3
pp. 835 - 847
published_at 2013-01
Creators :
Sakaida Isao
Yamashita Satoyoshi
Kobayashi Tomoo
Komatsu Masafumi
Sakai Terufumi
Komorizono Yasuji
Okada Mitsuru
Okita Kiwamu
Publishers : Cambridge Medical Publications Ltd
Hepatology research : the official journal of the Japan Society of Hepatology Volume 43 Issue 5
pp. 452 - 458
published_at 2013-05
Creators :
Kato Akinobu
Tanaka Hiroto
Kawaguchi Takumi
Kanazawa Hidenori
Iwasa Motoh
Sakaida Isao
Moriwaki Hisataka
Murawaki Yoshikazu
Suzuki Kazuyuki
Okita Kiwamu
Publishers : Elsevier
Critical care : the official journal of the Critical Care Forum Volume 17 Issue 3
published_at 2013-06-20
Creators :
Gando Satoshi
Saitoh Daizoh
Ogura Hiroshi
Fujishima Seitaro
Mayumi Toshihiko
Araki Tsunetoshi
Ikeda Hiroto
Kotani Joji
Kushimoto Shigeki
Miki Yasuo
Shiraishi Shin-ichiro
Suzuki Koichiro
Suzuki Yasushi
Takeyama Naoshi
Takuma Kiyotsugu
Tsuruta Ryosuke
Yamaguchi Yoshihiro
Yamashita Norio
Aikawa Naoki
Publishers : BioMed Central
Japanese journal of applied physics. Pt. 2, Letters Volume 35 Issue 2B
pp. 269 - 272
published_at 1996-02-15
Creators :
Nakajima Kazuki
Osa Atsushi
Kasaoka Shunji
Nakashima Ken
Maekawa Tsuyoshi
Tamura Toshiyo
Miike Hidetoshi
Publishers : Publication Office, Japanese Journal of Applied Physics
Brain research : international multidisciplinary journal devoted to fundamental research in the brain sciences Volume 1305
pp. 158 - 167
published_at 2009-12-11
Creators :
Ono Takeru
Tsuruta Ryosuke
Fujita Motoki
Shinagawa Aki Hiromi
Kutsuna Satoshi
Kawamura Yoshikatsu
Wakatsuki Jun
Aoki Tetsuya
Kobayashi Chihiro
Kasaoka Shunji
Maruyama Ikuro
Yuasa Makoto
Maekawa Tsuyoshi
Publishers : Elsevier
Cardiovascular research Volume 89 Issue 1
pp. 79 - 88
published_at 2011-01-01
Creators :
Aoyama Hidekazu
Ikeda Yasuhiro
Miyazaki Yosuke
Yoshimura Koichi
Nishino Shizuka
Yamamoto Takeshi
Yano Masafumi
Inui Makoto
Aoki Hiroki
Matsuzaki Masunori
Publishers : British Medical Association | Elsevier Science
Journal of atherosclerosis and thrombosis Volume 19 Issue 2
pp. 194 - 204
published_at 2012-02-25
Creators :
Sasaki Jun
Yokoyama Mitsuhiro
Matsuzaki Masunori
Saito Yasushi
Origasa Hideki
Ishikawa Yuichi
Oikawa Shinichi
Itakura Hiroshige
Hishida Hitoshi
Kita Toru
Kitabatake Akira
Nakaya Noriaki
Sakata Toshiie
Shimada Kazuyuki
Shirato Kunio
Matsuzawa Yuji
Publishers : Japan Atherosclerosis Society
Cardiovascular ultrasound Volume 9
pp. 30 -
published_at 2011-11
Creators :
Murata Kazuya
Ueyama Takeshi
Tanaka Takeo
Nose Yoshio
Wada Yasuaki
Matsuzaki Masunori
Publishers : BioMed Central
Atherosclerosis Volume 219 Issue 2
pp. 743 - 749
published_at 2011-12
Creators :
Hibi Kiyoshi
Kimura Takeshi
Kimura Kazuo
Morimoto Takeshi
Hiro Takafumi
Miyauchi Katsumi
Nakagawa Yoshihisa
Yamagishi Masakazu
Ozaki Yukio
Saito Satoshi
Yamaguchi Tetsu
Daida Hiroyuki
Matsuzaki Masunori
Publishers : Elsevier | Elsevier Science Ireland
Circulation journal : official journal of the Japanese Circulation Society
pp. CJ-12-0033 -
published_at 2012-04-05
Creators :
Kobayashi Shigeki
Susa Takehisa
Tanaka Takeo
Murakami Wakako
Fukuta Seiko
Okuda Shinichi
Doi Masahiro
Wada Yasuaki
Nao Tomoko
Yamada Jutaro
Okamura Takayuki
Yano Masafumi
Matsuzaki Masunori
Publishers : Japanese Circulation Society
Infection and immunity Volume 75 Issue 3
pp. 1393 - 1402
published_at 2007-03
Creators :
Kitagawa Takao
Hoshida Hisashi
Akada Rinji
Publishers : American Society for Microbiology
Yeast Volume 23 Issue 5
pp. 399 - 405
published_at 2006-04-15
Creators :
Akada Rinji
Kitagawa Takao
Kaneko Shohei
Toyonaga Daiso
Ito Sachiko
Kakihara Yoshito
Hoshida Hisashi
Morimura Shigeru
Kondo Akihiko
Kida Kenji
Publishers : John Wiley | Wiley
Hemoglobin : international journal for hemoglobin research Volume 36 Issue 5
pp. 446 - 455
published_at 2012-08
Creators :
Cho Yuko
Iizuka Susumu
Hatae Yoshio
Kobayashi Kunihiko
Hattori Yukio
Yamashiro Yasuhiro
Ariga Tadashi
Publishers : Marcel Dekker
Bioscience, biotechnology, and biochemistry Volume 71 Issue 3
pp. 772 - 782
published_at 2007-03-23
Creators :
Kitagawa Takao
Hashizume Yuko
Murakane Tatsuhiko
Koga Emi
Nomura Yuki
Kakihara Yoshito
Fujieda Ayako
Uchida Motoyuki
Takahashi Hidetoshi
Hoshida Hisashi
Akada Rinji
Publishers : Japan Society for Bioscience, Biotechnology, and Agrochemistry | 公益社団法人日本農芸化学会
Cancer genetics and cytogenetics Volume 188 Issue 2
pp. 70 - 76
published_at 2009-01
Creators :
Nakao Motonao
Kawauchi Shigeto
Furuya Tomoko
Adachi Jun
Okada Takae
Ikemoto Kenzo
Oga Atunori
Sasaki Kohsuke
Publishers : Elsevier
IAPR Workshop on Machine Vision Applications, November 28-30, 2000, The University of Tokyo, Japan
pp. 493 - 496
published_at 2000
Practica otologica Kyoto Volume 106 Issue 6
pp. 505 - 508
published_at 2013
The bulletin of the Yamaguchi Medical School Volume 66 Issue 1-2
pp. 29 - 35
published_at 2019
Creators :
Hanazono Tadasuke
Hidaka Isao
Maeda Masaki
Saeki Issei
Iwamoto Takuya
Ishikawa Tsuyoshi
Takami Taro
Yamasaki Takahiro
Sakaida Isao
Publishers : Yamaguchi University School of Medicine
日本外科学会雑誌 Volume 113 Issue 臨時増刊号2
pp. 423 - 423
published_at 2012-03-05
脳と発達 Volume 43 Issue 2
pp. 118 - 122
published_at 2011-03-01
The journal of the Japanese Association for Chest Surgery Volume 28 Issue 6
pp. 718 - 724
published_at 2014
Creators :
Nakamura Tamami
Sudoh Manabu
Kobayashi Seiki
Tamai Makoto
Ueda Kazuhiro
Hamano Kimikazu
Publishers : 日本呼吸器外科学会
山口医学 Volume 67 Issue 1
pp. 27 - 32
published_at 2018-02-01
Creators :
Suehiro Yuki
Harada Eijiro
Kawamura Daichi
Kugimiya Naruji
Takemoto Yoshihiro
Hamano Kimikazu
Publishers : 山口大学医学会
Apico-aortic valved conduit for aortic stenosis in patients who could not tolerate median sternotomy
The Japanese journal of thoracic surgery Volume 66 Issue 13
pp. 1132 - 1136
published_at 2013-12
山口医学 Volume 67 Issue 1
pp. 43 - 48
published_at 2018-02-01
Creators :
Satou Youko
Fukamitu Gaku
Yamamoto Shigeru
Nagano Hiroaki
Hamano Kimikazu
Publishers : 山口大学医学会
Carcinogenesis Volume 33 Issue 1
pp. 41 - 48
published_at 2012
Creators :
Hirata Hiroshi
Hinoda Yuji
Ueno Koji
Shahryari Varahram
Tabatabai Z. Laura
Dahiya Rajvir
Publishers : IRL Press | Oxford University Press
Cancer : a journal of the American Cancer Society Volume 117 Issue 8
pp. 1649 - 1660
published_at 2011-04-15
Creators :
Hirata Hiroshi
Hinoda Yuji
Majid Shahana
Chen Yi
Zaman Mohd S.
Ueno Koji
Nakajima Koichi
Tabatabai Z. Laura
Ishii Nobuhisa
Dahiya Rajvir
Publishers : Paul B. Hoeber | American Cancer Society
Proceedings of International Conference on Mechatronics and Information Technology (Yamaguchi,Japan,13-15 December 2001) No.76SS Volume 76SS
pp. 185 - 188
published_at 2001
Creators :
Kawamura Takeo
Matsumoto Tsuneo
Miura Gouji
Tanaka Nobuyuki
Awaya Hitomi
Emoto Takuya
Matsunaga Naofumi
Kido Shoji
Yokoyama Kenjiro
Yonezawa Shinji
Jiang Zhongwei
Spinal surgery : official journal of the Japanese Society of Spinal Surgery Volume 26 Issue 1
pp. 98 - 100
published_at 2012-04-25
日本医療薬学会年会講演要旨集 Volume 21
pp. 369 - 369
published_at 2011-09-09
日本医療薬学会年会講演要旨集 Volume 21
pp. 294 - 294
published_at 2011-09-09
Diagnostic microbiology and infectious disease Volume 74 Issue 3
pp. 230 - 235
published_at 2012-11
Creators :
Tsuruoka Keiko
Tsuneoka Hidehiro
Kawano Mitsunobu
Yanagihara Masashi
Nojima Junzo
Tanaka Tatehiko
Yamamoto Misa
Ichihara Kiyoshi
Publishers : Elsevier Science Pub. | Elsevier Science
【背景】全層性治癒(Transmural healing healing; TH)は、クローン病の新たな治療標的として注目されているが、日本ではTHに関する臨床データはほとんどない。我々は、クローン病のモニタリング法として低被曝線量CTエンテログラフィ(CTE)を導入し、CTEによるTHの評価をレトロスペクティブに検討した。【方法】2009年 1月から2021年3月までに当院で低被曝線量CTEを施行したクローン病患者のうち、2週間以内に大腸内視鏡検査またはバルーン内視鏡検査を施行した122例を対象とした。放射線検査と内視鏡検査の結果は、それぞれ放射線科医と消化器内視鏡医が独立して検討した。CTEと内視鏡検査の診断の一致率を算出した。【結果】26名(21.3%)のクローン病患者がTHを達成し、カッパ係数は0.743と2人の放射線科医の間でかなりの一致が見られた。TH群と非TH群の比較では、クローン病活動指数(Crohn’s Disease Activity Index ; CDAI )(P値 = 0.02)、内視鏡的治癒率(P値 < 0.001)、血清アルブミン(P値 = 0.043)、血清C反応性蛋白(P値 = 0.018)に有意差が認められた。122名の患者のうち、69名(56.5%)はCTEの診断と内視鏡検査が一致し、22名(18.0%)はTHと内視鏡の両方の治癒を達成した。【結論】本研究は、日本における低被曝線量CTEによるクローン病のリアルワードデータを示すものである。本研究で用いたTHの基準はカッパ係数が高く、多くの施設で再現性を持って用いることができると考えられる。
Creators :
藤村 寛之
【背景】近年、歯周炎や歯肉炎に関連する嫌気性グラム桿菌であるFusobacterium nucleatum (F. nucleatum) は大腸がんの発生や進行に関与することが報告されている。この菌の制御が大腸がんの予防につながる可能性があると考え、深紫外線発光ダイオード (DUV-LED) によるF. nucleatumの殺菌効果を検討した。【方法】DUV-LEDのF. nucleatumに対する殺菌効果を定性的、定量的に評価した。ピーク波長が265nmと280nmの2種類のDUV-LEDを使用した。F. nucleatumのDNAに対するダメージは、シクロブタンピリミジン二量体(CPD)とピリミジンピリミドン光生成物 (6-4PP) の生成で評価した。【結果】DUV-LEDでの265nmまたは280nmの波長を3分間照射したところ、コロニーの成長は観察されなかった。265nmのDUV-LED光照射下におけるF. nucleatumの生存率は10秒照射で0.0014%、20秒照射で0%に低下した。同様に、280nmのDUV-LED光照射では,10秒照射で0.00044%、20秒照射で0%に低下した。DUV-LEDから35mmの距離での放射照度は、265nmのLEDで0.265mW/cm^2、280nmのLEDでは0.415mW/cm^2であった。従って、致死量を示す放射エネルギーは265nm LEDは5.3mJ/cm^2、280nm LEDは8.3mJ/cm^2であった。265nmと280nmのDUV-LED光をF. nucleatumに照射した際のCPDと6-4PPの量はそれぞれ6.548ng/μg、1.333ng/μgであった。【結論】DUV-LED光は、F. nucleatumに対して、ピリミジン二量体を形成することにより殺菌効果を発揮した。
Creators :
伊藤 駿介
前身に投与された治療薬が脳組織実質に到達するには、神経組織の血管により形成される血液脳関門を通過する必要がある。そのため、組織への損傷を最小限に抑えて血液脳関門を開くことができれば、難治性神経疾患の治療法開発に大きな進展をもたらすことが期待される。本研究では、血液脳関門を形成する血管内皮細胞に発現するBasiginに着目し、その内因性リガンドであるCyclophilin A (CypA) を用いて、血液脳関門機能を人為的に制御することを目的とした。マウス脳血管内皮細胞株を用いたin vivo解析により、CypAの投与がBasiginを介して血液脳関門機能を低下させること、それにより脳実質へ効率的に薬物を送達できることを示した。単層培養された血管内皮細胞において、CypAはタイト結合構成分子の一つであるClaudin-5を一過性かつ可逆的に細胞膜から消失させて、バリアー機能を低下させることを見出した。また、マウスへのCypAの単回静脈内投与では血液脳関門が一定期間開いた後、自発的に元の状態へ回復することが示され、そしてその限定された機関において、全身投与された水溶性薬物Doxorubicinが脳組織実質へ送達されることが明らかとなった。本研究の結果は、CypAの静脈内投与によって、脳実質への薬物送達を自在にコントロールできることを示しており、難治性神経疾患に対する治療法確立に向けた重要な成果であると考えられる。
Creators :
本田 成美
The hippocampal dentate gyrus has been identified to play a critical role in maintaining contextual memory in many mammalian species. To evaluate learning-induced synaptic plasticity of granule cells, we subjected male rats to an inhibitory avoidance (IA) task and prepared acute hippocampal slices. In the presence of 0.5 µM tetrodotoxin, we recorded miniature EPSCs in male rats experiencing four groups: untrained, IA-trained, unpaired, and walk-through. Compared with the untrained, IA-trained, unpaired, and walk-through groups, the unpaired group significantly enhanced mean mEPSC amplitudes, suggesting the experience-induced plasticity at AMPA receptor-mediated excitatory synapses. For inhibitory synapses, both unpaired and walk-through groups significantly decreased mean mIPSC amplitudes, showing the experience-induced reduction of postsynaptic GABA_A receptor-mediated currents. Unlike the plasticity at CA1 synapses, it was difficult to explain the learning-specific plasticity at the synapses. However, overall multivariate analysis using four variables of mE(I)PSC responses revealed experience-specific changes in the diversity, suggesting that the diversity of excitatory/inhibitory synapses onto granule cells differs among the past experience of animals include the learning.
In comparison with CA1 pyramidal neurons, granule cells consistently showed greater amplitude and frequency of mE(I)PSCs. Fluctuation analysis further revealed that granule cells provide more postsynaptic AMPA receptor channels and greater single-channel current of GABA_A receptors of than CA1 pyramidal neurons. These findings show functional differences between two types of principal cells in the hippocampus.
Creators :
Han Thiri Zin
Cardiovascular diseases are the leading cause of mortality and disability worldwide. We have previously found that sphingosylphorsphorylcholine (SPC) is the key molecule leading to vasospasm. We have also identified the SPC/Src family protein tyrosine kinase Fyn/Rho-kinase (ROK) pathway as a novel signaling pathway for Ca^{2+}-sensitization of vascular smooth muscle (VSM) contraction. The present study aimed to investigate whether hesperetin can inhibit the SPC-induced contraction with little effect on 40 mM K^+-induced Ca^{2+}-dependent contraction and to elucidate the underlying mechanisms. Hesperetin significantly inhibited the SPC-induced contraction of porcine coronary artery smooth muscle strips with little effect on 40 mM K^+-induced contraction. Hesperetin blocked the SPC-induced translocation of Fyn and ROK from the cytosol to the membrane in human coronary artery smooth muscle cells (HCASMCs). SPC decreased the phosphorylation level of Fyn at Y531 in both VSMs and HCASMCs and increased the phosphorylation levels of Fyn at Y420, myosin phosphatase target subunit 1 (MYPT1) at T853 and myosin light chain (MLC) at S19 in both VSMs and HCASMCs, which were significantly suppressed by hesperetin. Our results indicate that hesperetin inhibits the SPC-induced contraction at least in part by suppressing the Fyn/ROK pathway, suggesting that hesperetin can be novel drug to prevent and treat vasospasm.
Creators :
Lu Qian