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An invited review following the Soujinkai Award: Human Induced Pluripotent Stem Cell Modeling of the Blood-Brain Barrier Identifies Intrinsic Barrier Dysfunction in Multiple Sclerosis

Medical Science & Innovation Volume 72 Issue 1-2

Blood-brain barrier (BBB) dysfunction found in the multiple sclerosis (MS) cases is generally considered as a consequence of neuroinflammation. In this study we challenge this view by developing and analyzing novel BBB model from MS patients using induced pluripotent stem cells (iPSCs). We differentiated iPSCs into brain microvascular endothelial cell (BMEC)-like cells to establish an in vitro BBB model. We found that BMEC-like cells from MS patients exhibited compromised barrier integrity, characterized by weakened junctions, heightened permeability, and an elevated inflammatory profile when compared to cells from healthy individuals. Notably, the activation of the Wnt/β-catenin signaling pathway led to improvements in barrier function and a reduction in inflammatory responses, indicating potential therapeutic targets for reinforcing BBB stability in MS.

Creators : Nishihara Hideaki Publishers : Yamaguchi University School of Medicine Date Issued : 2025-06

An Invited Review following the Soujinkai Young Investigator Award: Modulating Calmodulin-Ryanodine Receptor Binding as a Strategy to Halt Pressure-Overload Induced Cardiac Hypertrophy

Medical Science & Innovation Volume 72 Issue 1-2

Cardiac hypertrophy is widely recognized as a significant risk factor contributing to adverse outcomes in individuals with cardiovascular conditions. The disruption of intracellular calcium ( Ca^{2+} ) balance has been implicated in the development of cardiac hypertrophy, though the precise mechanisms remain poorly understood. In this research, we explored whether hypertrophy induced by pressure overload may arise from the destabilization of the cardiac ryanodine receptor (RyR2) triggered by the dissociation of calmodulin (CaM), leading to subsequent Ca^{2+} leakage. We also assessed whether genetically strengthening the binding affinity between CaM and RyR2 could potentially reverse this process. In the early phases of cardiac hypertrophy caused by pressure overload—when contractile function is still intact—we observed that RyR2 destabilization mediated by reactive oxygen species (ROS) coincides with impaired relaxation. Moreover, stabilizing RyR2 through enhanced CaM binding was found to completely inhibit hypertrophic signaling and improve survival rates. Our findings reveal a crucial connection between RyR2 destabilization and the progression of cardiac hypertrophy.

Creators : Kohno Michiaki | Kobayashi Shigeki | Yamamoto Takeshi | Yano Masafumi Publishers : Yamaguchi University School of Medicine Date Issued : 2025-06

Current Status and Challenges of the Harassment Prevention System at Yamaguchi University

Bulletin of Clinical Psychology Service Center, Graduate School of Education, Yamaguchi University Volume 15

Creators : Satake Keisuke Publishers : 山口大学大学院教育学研究科附属臨床心理センター Date Issued : 2025-02-28

Study on the Image of Fathers and Mothers among University Students

Bulletin of Clinical Psychology Service Center, Graduate School of Education, Yamaguchi University Volume 15

Creators : Kasuga Yumi | Satake Keisuke Publishers : 山口大学大学院教育学研究科附属臨床心理センター Date Issued : 2025-02-28

自傷行為の反復の場としてのアセスメント面接状況

Bulletin of Clinical Psychology Service Center, Graduate School of Education, Yamaguchi University Volume 15

Creators : Tsuneyoshi Tetsuzo Publishers : 山口大学大学院教育学研究科附属臨床心理センター Date Issued : 2025-02-28

心理臨床の先達 : 前田重治先生への追悼文

Bulletin of Clinical Psychology Service Center, Graduate School of Education, Yamaguchi University Volume 15

Creators : Tsuneyoshi Tetsuzo Publishers : 山口大学大学院教育学研究科附属臨床心理センター Date Issued : 2025-02-28

Non-attendance in University Students

山口大学学生相談所年報 Volume 33

Creators : Kasuga Yumi Publishers : 山口大学教育・学生支援機構学生支援センター Date Issued : 2025-03-31

Operational Roles of Student Counseling Center during a Major Earthquake : The Tohoku University's Response to the Great East Japan Earthquake , and Preparedness at Our Institution

山口大学学生相談所年報 Volume 33

Creators : Saito Hiroko | Satake Keisuke Publishers : 山口大学教育・学生支援機構学生支援センター Date Issued : 2025-03-31

Find out what we can do at The Yamaguchi University Student Counseling Center in the event of a major disaster from Kumamoto Earthquake

山口大学学生相談所年報 Volume 33

Creators : Kawai Kanako Publishers : 山口大学教育・学生支援機構学生支援センター Date Issued : 2025-03-31

遠隔相談を通してコロナ後の学生相談を考える

山口大学学生相談所年報 Volume 33

Creators : Hironaka Kyoko Publishers : 山口大学教育・学生支援機構学生支援センター Date Issued : 2025-03-31

近年の工学部学生相談の傾向について

山口大学学生相談所年報 Volume 33

Creators : Motoyoshi Sayo Publishers : 山口大学教育・学生支援機構学生支援センター Date Issued : 2025-03-31

Michio Morishima’s Economic Linkage Analysis (2) : Monetary Policy

Yamaguchi journal of economics, business administrations & laws Volume 73 Issue 5

Creators : Kato Shinya | Kojima Hisashi Publishers : The Economic Society of Yamaguchi University Date Issued : 2025-01-31

“The Science of Eating Pufferfish” Era, and Its Founders, Tokuji Fukuda and Iwao Tani : The History of Food Hygiene in the Mid-Showa Period in Japan

Yamaguchi journal of economics, business administrations & laws Volume 73 Issue 5

Creators : Furukawa Sumiaki Publishers : The Economic Society of Yamaguchi University Date Issued : 2025-01-31

A Study on Former International Students Working in Remote Areas in Japan : Cases of Indonesian Graduates

Yamaguchi journal of economics, business administrations & laws Volume 73 Issue 5

Creators : Asamizu Munehiko | Layendra Michell Publishers : The Economic Society of Yamaguchi University Date Issued : 2025-01-31

Appearance of Buddha Sakya- muni in the Indian Section (Tenjiku-bu) of Konjaku Monogatari-shū