journal article

We have developed ACTce‑CCM̶ Analysis and Coordination Tools of Clinical Ethics in Critical Care Medicine. The preparation process was carried out in four stages:construct setting and prototype creation, application of prototype version to fictitious cases, clarification of the construct based on focus group interviews, and a fact-finding survey on ethical issues and ethical adjustment. The completed version of ACTce-CCM consists of information organization and assessment frameworks, problem analysis and integration, problem lists, goals, care practices, and ethical adjustment. There are six frameworks for information organization and assessment:pathology and treatment, QOL and QOD, patient intention, family psychosocial situation, medical team situation, and the surrounding situation. The problem lists include those related to the patient, the family, and the medical staff. Goals include those of the medical team and the expected outcomes for the patient/family. Care practices and ethical adjustment consist of three aspects: direct patient care, direct family care, and medical team adjustment.

This study aimed to clarify outcome of the public health nursing practice conducted under the influence of COVID-19. A self-administered anonymous questionnaire survey was performed for 4th grader students at University from 2018 through 2020. The investigation items consisted of basic attributes, impression of public health nurse activity, learning motivation and learning target items. We compared shortened clinical practice and online practice enforced in 2020 and before. For 217 effective answers,＂A public health nurse was involved in practice sufficiently＂ was significantly low. In top learning achievement scores of 2020 included many of the items from the the learning target＂Process of public health nursing activity＂ and ＂Role and function of public health center and municipalities. In 2018 and 2019, learning achievement degrees were over 80% in 94.3% of 53 items while on the other hand it was only 32.1% in 2020. Learning achievement degrees were less than 60% in no items in 2018 and 2019 while it was 15.1% in 2020. For the techniques of health service and health practice for which the learning achievement degree were low in 2020, it is necessary to support students so that they can acquire them as a public health nursing practice ability.

To realize a stable and efficient wireless power transfer (WPT) system that can be used in any environment, it is necessary to inspect the influence of environmental interference along the power transmission path of the WPT system. In this paper, attempts have been made to reduce the influence of the medium with a dielectric and conductive loss on the WPT system using spiral resonators for resonator-coupled type wireless power transfer (RC-WPT) system. An important element of the RC-WPT system is the resonators because they improve resonant characteristics by changing the shape or combination of spiral resonators to confine the electric field that mainly causes electrical loss in the system as much as possible inside the resonator. We proposed a novel dual-spiral resonator as a candidate and compared the basic characteristics of the RC-WPT system with conventional single-spiral and dual-spiral resonators. The parametric values of the spiral resonators, such as the quality factors and the coupling coefficients between resonators with and without a lossy medium in the power transmission path, were examined. For the lossy mediums, pure water or tap water filled with acryl bases was used. The maximum transmission efficiency of the RC-WPT system was then observed by tuning the matching condition of the system. Following that, the transmission efficiency of the system with and without lossy medium was investigated. These inspections revealed that the performance of the RC-WPT system with the lossy medium using the modified shape spiral resonator, which is the dual-spiral resonator proposed in our laboratory, outperformed the system using the conventional single-spiral resonator.

We report the case of a 48-year-old woman with relapsed B-lineage acute lymphoblastic leukemia(B-ALL)following cord blood transplantation, in which leukemic cell CD22 antigens became negative after a single administration of inotuzumab ozogamicin(InO).At relapse, a major part of leukemic cells expressed CD19 and CD22 antigens, however some leukemic cells were negative for CD22. As treatment with blinatumomab proved ineffective, InO therapy was subsequently initiated

We performed this study to investigate whether serum cell-free DNA testing(liquid biopsy)of either methylated SEPT9 or methylated SST, which are possible biomarkers of HCC, in combination with AFP may improve clinical performance for the detection of HCC. Study subjects included 25 healthy controls, 15 patients with chronic liver disease without HCC, and 38 patients with HCC. Methylation level of serum cell-free SEPT9 and SST was measured by methylation-sensitive restriction enzymes followed by multiplex droplet digital polymerase chain reaction. According to receiver operating characteristic curve analysis to discriminate between non-HCC group(including control group and chronic liver disease without HCC group)and HCC group, area under the curve(AUC)was 0.73 by AFP and 0.73 by mSEPT9, whereas it was only 0.59 by mSST. Regarding combination tests, although negative predictive values were almost same between the AFP + mSEPT9 test and the AFP + mSST test(75.0% vs 72.2%),a positive predictive value of AFP + mSEPT9 test was higher than that of the AFP + mSST test(79.4% vs. 66.7%).In conclusions, methylated SEPT9 was a better companion marker of AFP for HCC screening than methylated SST.

先行研究では、技能実習生に関する日本語教育の問題点の１つとして、講習で教えられている日本語が作業現場で使われている日本語と相違していると指摘されている。しかし、具体的にどのような点で相違しているのかということについては明らかにされていない。技能実習生が作業現場で日本人の同僚からの指示を理解するためには、日本語の統語構造の特徴から、文末表現を理解することが欠かせないと考えられる。日本語の文末表現には、「発話の機能」を明示的に示す働きがある。命令か依頼かが文末表現を聞いて初めてわかるからである。そこで、本稿は鉄骨工場のような指示が多い作業現場をフィールドとし、そこでの、技能実習生に向けられた日本語母語話者の発話における文末表現の特徴を明らかにした。そのうえで、そこで明らかになった特徴と技能実習生向けの講習用教材の比較を通し、両者の、文末表現上の相違点を析出することを試みた。研究結果として、１）作業現場の発話には、言いさしが半数近くあり、よく使われていると言えるのに対し、講習用教材では、言い切りが主導的な地位を占めていること、２）作業現場では、普通体を主基調として、発話が進められているのに対し、講習用教材では、丁寧体を主使用文体としていること、３）作業現場では、「動詞等の∅形」の使用率は３分の１に足りないのに対し、講習用教材では「動詞等の∅形」の使用率は半数近くあること、４）作業現場では、相応の縮約形があるものについては、縮約形を使うのが一般的であるのに対し、講習用教材では、ほとんどの場合に、相応の縮約形があったとしても、元の形そのままで使われていることが明らかになった。このような状況を踏まえ、今後、講習において、作業現場で働く日本語母語話者の発話の文末表現をどのように導入し、教えたらいいのかについて、工夫が必要であると思われる。