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Creators : Srivastava Pratibha

A close relationship between plasma concentrations of branched-chain and aromatic amino acids and uric acid among healthy adults

The bulletin of the Yamaguchi Medical School Volume 68 Issue 3-4

Liquid biopsy test based on a sensitive dna methylation assay for diagnosing hepatocellular carcinoma : which is a better marker, methylated sst or sept9?

山口医学 Volume 70 Issue 3

We performed this study to investigate whether serum cell-free DNA testing(liquid biopsy)of either methylated SEPT9 or methylated SST, which are possible biomarkers of HCC, in combination with AFP may improve clinical performance for the detection of HCC. Study subjects included 25 healthy controls, 15 patients with chronic liver disease without HCC, and 38 patients with HCC. Methylation level of serum cell-free SEPT9 and SST was measured by methylation-sensitive restriction enzymes followed by multiplex droplet digital polymerase chain reaction. According to receiver operating characteristic curve analysis to discriminate between non-HCC group(including control group and chronic liver disease without HCC group)and HCC group, area under the curve(AUC)was 0.73 by AFP and 0.73 by mSEPT9, whereas it was only 0.59 by mSST. Regarding combination tests, although negative predictive values were almost same between the AFP + mSEPT9 test and the AFP + mSST test(75.0% vs 72.2%),a positive predictive value of AFP + mSEPT9 test was higher than that of the AFP + mSST test(79.4% vs. 66.7%).In conclusions, methylated SEPT9 was a better companion marker of AFP for HCC screening than methylated SST.

Altered levels of plasma free amino acids in hyperuricemia among male smokers

The bulletin of the Yamaguchi Medical School Volume 68 Issue 1-2

Efficacy of quantitative analysis for differentiating pancreatic solid lesions using contrast-enhanced endoscopic ultrasonography

The bulletin of the Yamaguchi Medical School Volume 68 Issue 1-2

Aim: To evaluate the efficacy of quantitative analysis for differentiating pancreatic ductal adenocarcinoma (PDAC) and inflammatory pancreatic masses (IPM) using time intensity curve (TIC) analysis based on contrast-enhanced endoscopic ultrasonography (CE-EUS). Methods: We reviewed 89 patients who had undergone CE-EUS for pancreatic solid lesions at our department between August 2012 and January 2016. CE-EUS images were recorded for 2 minutes after injection of the contrast agent. The diagnostic abilities of the enhanced patterns and TIC analysis were assessed. Results: The enhanced patterns of PDAC were mainly hypovascular and heterogeneous (66/77), while IPM were mainly isovascular and homogeneous (6/12). In PDAC, sensitivity was 77.9%, specificity 83.3%, and accuracy was 78.7%. In TIC analysis, the intensity reduction rate was significantly different at 10 and 30 seconds after peak intensity. After creating a cutoff value (49%) based on the receiver operating characteristic curve for the intensity reduction rate after 30 seconds, diagnosing PDAC with TIC analysis had a sensitivity of 67.5%, specificity of 100%, and accuracy of 71.9%. Combining enhanced pattern analysis with TIC analysis had a sensitivity of 90.9%, pecificity of 83.3%, and accuracy of 89.9%. Conclusion: Combining TIC analysis with CE-EUS improved diagnostic accuracy when differentiating between PDAC and IPM.

An invited review following the Soujinkai Fujiu Memorial Award : development of stent-enhanced 3d optical coherence tomography and its clinical application for coronary bifurcation lesions

The bulletin of the Yamaguchi Medical School Volume 68 Issue 1-2

Creators : Okamura Takayuki | Yano Masafumi Publishers : Yamaguchi University School of Medicine Date Issued : 2021

ラット胃の幽門部粘膜における腸管内分泌細胞とハンチンチン関連タンパク質HAP1の免疫組織化学的検討

Creators : 柳井章江

Investigation of the factors of attendance and continuous to participate in dementia café among community-dwelling seniors

山口医学 Volume 70 Issue 2

Creators : Fujimura Kazumi | Hase Ryosuke | Kijima Ayano | Okochi Ayako | Kumagai Tamaki Publishers : 山口大学医学会 Date Issued : 2021-05-13

Sterile inflammation as a novel therapeutic target to heart failure

山口医学 Volume 70 Issue 2

Creators : Suetomi Takeshi Publishers : 山口大学医学会 Date Issued : 2021-05-13

Nobiletin, a citrus flavonoid, suppresses SPC-induced abnormal vascular contraction

山口医学 Volume 70 Issue 1

Creators : Miyanari Kenji Publishers : 山口大学医学会 Date Issued : 2021-03-04

A case of raspberry-like foveolar-type gastric adenocarcinoma resected by strip biopsy

山口医学 Volume 70 Issue 1

The different effects of acacetin and biochanin A on abnormal contraction of vascular smooth muscle

山口医学 Volume 70 Issue 1

Creators : Zhang Min Publishers : 山口大学医学会 Date Issued : 2021-03-04

Paroxysmal sympathetic hyperactivity after traumatic brain injury experienced in Yamaguchi University

山口医学 Volume 70 Issue 1

Creators : Fujiyama Yuichi Publishers : 山口大学医学会 Date Issued : 2021-03-04

Rapid and sensitive detection of UGT1A1 polymorphisms associated with irinotecan toxicity by a novel DNA microarray

山口医学 Volume 69 Issue 4

Creators : Tsunedomi Ryouichi Publishers : 山口大学医学会 Date Issued : 2020-12-25

Intraoperative anaphylactic shock related to fibrin glue application during video-assisted thoracoscopic surgery

山口医学 Volume 69 Issue 3

Creators : Yano Yuka | Kuga Takayuki | Sakamoto Ryuunosuke | Shigeta Masatoshi | Iida Yasuhiko Publishers : 山口大学医学会 Date Issued : 2020-09-25

An invited review following the Soujinkai Young Investigator Award : calreticulin is highly expressed in pancreatic cancer stem-like cells

The bulletin of the Yamaguchi Medical School Volume 67 Issue 3-4

Creators : Matsukuma Satoshi | Yoshimura Kiyoshi | Tsunedomi Ryouichi | Hazama Shoichi | Nagano Hiroaki Publishers : Yamaguchi University School of Medicine Date Issued : 2020

An invited review following the Soujinkai Award : development of novel chimeric antigen receptor-expressing t cells promoting immune cell infiltration and survival in the tumor tissue

The bulletin of the Yamaguchi Medical School Volume 67 Issue 3-4

Creators : Adachi Keishi | Tamada Koji Publishers : Yamaguchi University School of Medicine Date Issued : 2020

MIG and I309 accelerates proliferation of human bone marrow-derived mesenchymal stem cells

The bulletin of the Yamaguchi Medical School Volume 67 Issue 1-2

Creators : Aibe Yuki | Takami Taro | Fujisawa Koichi | Matsumoto Toshihiko | Sakaida Isao Publishers : Yamaguchi University School of Medicine Date Issued : 2020

Current status of rifaximin treatment for hepatic encephalopathy at our hospital

山口医学 Volume 69 Issue 2

Creators : Iwamoto Takuya | Sakaida Isao Publishers : 山口大学医学会 Date Issued : 2020-05-01

Bartonella henselae DNA in seronegative patients with cat-scratch disease

山口医学 Volume 69 Issue 1

Creators : Yanagihara Masashi Publishers : 山口大学医学会 Date Issued : 2020-02-28