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An invited review following the Soujinkai Award : development of novel chimeric antigen receptor-expressing t cells promoting immune cell infiltration and survival in the tumor tissue

The bulletin of the Yamaguchi Medical School Volume 67 Issue 3-4 Page 11-17
published_at 2020
A050067000301.pdf
[fulltext] 1.07 MB
Title
An invited review following the Soujinkai Award : development of novel chimeric antigen receptor-expressing t cells promoting immune cell infiltration and survival in the tumor tissue
Creators Adachi Keishi
Creators Tamada Koji
Source Identifiers
Creator Keywords
solid tumor T cell  CAR-T cell IL-17 CCL19
Chimeric Antigen Receptor (CAR) -T cell therapy is attracting the attention for its remarkable therapeutic efficacy on hematological malignancies. Meanwhile, some serious issues currently remain in CAR-T cell therapy, one of which is the ineffectiveness against solid tumors. In order to overcome the issue, we developed the next generation CAR-T cell which simultaneously produce IL-7 and CCL19 (7×19 CAR-T cell). In several solid tumor mouse models, administration of 7 × 19 CAR-T cells induced conspicuous infiltrations of T cells and dendritic cells (DCs) inside the tumor tissues, and exert potent antitumor efficacies in cooperation with the recipient T cells. In addition, a long-term immunological memory against the tumor was formed after the treatment, suggesting that the treatment with 7×19 CAR-T cells enabled the prevention of cancer recurrence. In conclusion, our study concerning the next-generation CAR-T cell is expected to lead an innovative therapy against solid tumors.
Languages eng
Resource Type departmental bulletin paper
Publishers Yamaguchi University School of Medicine
Date Issued 2020
File Version Version of Record
Access Rights open access
Relations
[ISSN]0513-1812
[NCID]AA00594272
Schools 大学院医学系研究科(医学)