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A case of chronic hepatitis c with charcot-marie-tooth disease successfully treated with interferon beta and rivabirin combination therapy

山口医学 Volume 64 Issue 1

A 36-year-old man diagnosed with Charcot-Marie-Tooth(CMT)disease type 1B was treated in the department of neurology of this hospital. Due to a liver injury(AST 237IU/ml, ALT 496IU/ml)which occurred in November 200X, he was introduced to our department. As a result of scrutiny, we diagnosed him with chronic hepatitis C genotype 2a(HCV-RNA 5.4logIU/ml).He will be admitted to the hospital for Interferon(IFN)therapy in April next year. Although the mechanism is unknown, there are a few reports of peripheral neuropathy related to IFN therapy. Therefore, IFN therapy is generally unfavorable for patients with neuromuscular disorders. There are several IFN preparations used in Japan. IFN alfa associated peripheral neuropathy appears less than 0.1-5% of the time. While there is no report of peripheral neuropathy related to IFN beta, we performed IFN beta and Rivabirin combination therapy with a severe follow-up by a neurologist. We could accomplish treatment without the exacerbation of neurologic symptoms. He achieved sustained viral response. When IFN therapy was provided for chronic hepatitis B or chronic hepatitis C complicated with peripheral neuropathy, there is some possibility of performing antiviral therapy safely by using IFN beta.

A case of early gastric cancer that developed 6 years after eradication of helicobacter pylori for nodular gastritis

山口医学 Volume 64 Issue 1

A case of cyclic thrombocytopenia complicated by drug-related damage to the small intestinal mucosa

山口医学 Volume 64 Issue 1

A case of ruptured hepatocellular carcinoma immediately after transcatheter arterial chemoembolization

山口医学 Volume 64 Issue 1

Spontaneous rupture of hepatocellular carcinoma(HCC)is well known. However, rupture of HCC after transcatheter arterial chemoembolization(TACE)is a rare but potentially fatal complication. Herein, we report a case of ruptured HCC after TACE in a 73-year-old man with chronic liver injury(non-B and non-C).He had previously undergone subsegmental resection of S7 of the liver for HCC. One year later, multiple HCCs were detected. TACE was performed for the recurrent HCCs located on the surface of S2 of the liver. Epigastric pain and decreased blood pressure were observed after the treatment. Although his symptoms improved immediately, the patient gradually became anemic. Radiological examination after TACE revealed a hematoma around the S2 lesion. Therefore, we diagnosed rupture of HCC. We performed TAE and could control the bleeding. Few possible mechanisms of ruptured HCC after TACE include increasing pressure inside the tumor and capsular injury due to TACE. Consequently, HCC which has a high risk of rupture after TACE should be assured embolization and careful observation.

Introducing comprehensive community health care clerkships in depopulated areas

山口医学 Volume 64 Issue 1

Evidence for the treatment of hypertension with combination therapy and the cope trial

山口医学 Volume 64 Issue 1

Creators : Umemoto Seiji Publishers : 山口大学医学会 Date Issued : 2015-02-01

Phase II trial of zoledronic acid combined with androgen-deprivation therapy for treatment-naive prostate cancer with bone metastasis

ICCJ Volume 19 Issue 4

The change with time of some stress in the 5 days after delivery : Investigated and compared pregnancies over the age of 35 with those under 35

Japanese journal of maternal health Volume 55 Issue 1

Real-time Ultrasound-guided endoscopic surgery for intracranial hemorrhage with a Burr hole type probe

脳卒中の外科 Volume 42 Issue 3

A case of resected metachronous large cell neuroendocrine carcinoma and spindle cell carcinoma

The journal of the Japanese Association for Chest Surgery Volume 28 Issue 6

The effectiveness of intercostal nerve block during complete video-assisted thoracic surgery

The journal of the Japanese Association for Chest Surgery Volume 28 Issue 6

Pathophysiology and management of mild traumatic brain injury

日本救急医学会雑誌 Volume 25 Issue 5

Creators : Miyauchi Takashi | Fujita Motoki | Suehiro Eiichi | Oda Yasutaka | Tsuruta Ryosuke Publishers : 日本救急医学会 Date Issued : 2014

Intestinal prolapse through the drain site after Laparoscopy-Assisted low anterior resection: A case report

Journal of Japanese College of Surgeons Volume 38 Issue 4

Crosstalk of clusterin expression with androgen receptor signal transduction and its therapeutic target for castration-resistant prostate cancer

西日本泌尿器科 Volume 75 Issue 4

Creators : Matsumoto Hiroaki | Matsuyama Hideyasu Publishers : 日本泌尿器科学会西日本総会 Date Issued : 2013-04-20

Quantitative assessment of rest and acetazolamide CBF using quantitative SPECT reconstruction and sequential administration of ＾{123}I-iodoamphetamine : comparison among data acquired at three institutions

Annals of Nuclear Medicine Volume 28 Issue 9

operative treatment for scaphoid osteonecrosis (preiser disease) : salvage or excision? Report on two cases and a review of the literature

Ann Plast Surg Volume 73 Issue 5

Creators : Muramatsu Keiichi | Hashimoto Takahiro | Tominaga Yasuhiro | Taguchi Toshihiko | Kido Kenji Publishers : Little Brown Date Issued : 2014-11

Hypoxic preconditioning reinforces cellular functions of autologous peripheral blood-derived cells in rabbit hindlimb ischemia model

Biochemical and biophysical research communications Volume 444 Issue 3

Hypoxically preconditioned human peripheral blood mononuclear cells improve blood flow in hindlimb ischemia xenograft model

Am J Transl Res Volume 6 Issue 5

Satisfaction and subjective symptoms after instillation of tafluprost or travoprost for twelve weeks each

Japanese journal of clinical ophthalmology Volume 68 Issue 7

Guideline for economic evaluation of healthcare technologies in Japan

保健医療科学 Volume 62 Issue 6