The bulletin of the Yamaguchi Medical School
Continued by：Medical Science & Innovation
EISSN：2758-5441
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The bulletin of the Yamaguchi Medical School Volume 54 Issue 3-4
published_at 2007
Simvastatin reduces secretion of monocyte chemoattractant proteins and matrix metalloproteinase-9 in human abdominal aortic aneurysms
Simvastatin reduces secretion of monocyte chemoattractant proteins and matrix metalloproteinase-9 in human abdominal aortic aneurysms
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Descriptions
Recent studies have suggested that HMG-CoA reductase inhibitors (statins) attenuate the growth of human abdomical aortic aneurysm (AAA), which is characterized by chronic inflammation and degradation of the extracellular matrix by metalloproteinases (MMPs). While the effects of statins on inflammatory proteins have been reported, the molecular mechanism for the effect of statins on human AAA is largely unknown. Thus, the aim of this study was to elucidate the direct effect of statin on proinflammatory mediators in human AAA walls. Among 79 molecules analyzed by cytokine array, monocyte chemoattractant protein (MCP)-1 and MCP-3 were identified as markedly increased chemokines in human AAA…
Creator Keywords
aortic aneurysm
statin
MCP-1
MCP-3
MMP-9
Other Article
PP. 29 - 31