Simvastatin reduces secretion of monocyte chemoattractant proteins and matrix metalloproteinase-9 in human abdominal aortic aneurysms
The bulletin of the Yamaguchi Medical School Volume 54 Issue 3-4
Page 47-56
published_at 2007
Title
Simvastatin reduces secretion of monocyte chemoattractant proteins and matrix metalloproteinase-9 in human abdominal aortic aneurysms
Source Identifiers
Creator Keywords
aortic aneurysm
statin
MCP-1
MCP-3
MMP-9
Recent studies have suggested that HMG-CoA reductase inhibitors (statins) attenuate the growth of human abdomical aortic aneurysm (AAA), which is characterized by chronic inflammation and degradation of the extracellular matrix by metalloproteinases (MMPs). While the effects of statins on inflammatory proteins have been reported, the molecular mechanism for the effect of statins on human AAA is largely unknown. Thus, the aim of this study was to elucidate the direct effect of statin on proinflammatory mediators in human AAA walls. Among 79 molecules analyzed by cytokine array, monocyte chemoattractant protein (MCP)-1 and MCP-3 were identified as markedly increased chemokines in human AAA…
Languages
eng
Resource Type
departmental bulletin paper
Publishers
Yamaguchi University School of Medicine
Date Issued
2007
File Version
Version of Record
Access Rights
open access
Relations
[isVersionOf]
[URI]http://ds.cc.yamaguchi-u.ac.jp/~bulletin/index.html
Schools
医学部