Immunohistochemical Examination of Meningioma

Immunohistochemical characteristics were examined in 76 cases of primary meningioma, 10 cases of recurrent meningioma, 3 cases of hemangiopericytoma and 2 cases of meningeal sarcoma. Six antibodies, those against epithelial membrane antigen, vimentin, cytokeratin, S-100 protein and alpha-1-antitrypsin, and 80-90% for neuron-specific enolase. Cytokeratin was negative in all cases. In recurrent meningioma, positivity rates for viementin were slightly lower in comparsion with promary meningioma. The man staining patterns of epithelial membrance antigen, vimentin, S-100 protein and alpha-1-antitrypsin were diffuse and that of neuron-specific enolase was focal. In hemagiopericytoma and meningeal sarcoma, epithelial membrane antigen and cytokeratin were negative and the other antigens were positive. Positivity for epithelial membrance antigen is thus of some use in distinguishing meningioma from hemagiopericytma or meningeal sarcoma. However vimentin, S-100 protein, neuron-spcific enolase and alpha-1-antitrypsin are not specific.

Meningioma

Hemangiopericytyoma

Immunohistochemistry

Epithelial membrane antigen

Vimentin