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An angiotensin II receptor blocker-calcium channel blocker combination prevents cardiovascular events in elderly high-risk hypertensive patients with chronic kidney disease better than high-dose angiotensin II receptor blockade alone

Kidney international Volume 83 Issue 1

Creators : Kim-Mitsuyama Shokei | Ogawa Hisao | Matsui Kunihiko | Jinnouchi Tomio | Jinnouchi Hideaki | Arakawa Kikuo Publishers : Springer-Verlag Date Issued : 2013-01

システマティックレビューの方法とその限界

The Japanese journal of clinical pathology Volume 60 Issue 7

Creators : 石田博 | 井上裕二 Publishers : 日本臨床検査医学会 Date Issued : 2012-07-25

EBLM実践のためのデータベースの必要性とその構想

The Japanese journal of clinical pathology Volume 60 Issue 7

Creators : 市原清志 Publishers : 日本臨床検査医学会 Date Issued : 2012-07-25

Genetic and epigenetic changes in colorectal cancer and genetic testing for personalized medicine

The Japanese journal of clinical pathology Volume 60 Issue 10

Creators : Suehiro Yutaka | Hinoda Yuji Publishers : 日本臨床検査医学会 Date Issued : 2012-10

IL-23-independent induction of IL-17 from γδT cells and innate lymphoid cells promotes experimental intraocular neovascularization

Journal of immunology Volume 190 Issue 4

Creators : Hasegawa Eiichi | Sonoda Koh-Hei | Shichita Takashi | Morita Rimpei | Sekiya Takashi | Kimura Akihiro | Oshima Yuji | Takeda Atsunobu | Yoshimura Takeru | Yoshida Shigeo | Ishibashi Tatsuro | Yoshimura Akihiko Publishers : American Association of Immunologists Date Issued : 2013-02-15

Acute retinal necrosis : Factors associated with anatomic and visual outcomes

Japanese journal of ophthalmology Volume 57 Issue 1

Creators : Iwahashi-Shima Chiharu | Azumi Atsushi | Ohguro Nobuyuki | Okada Annabelle A. | Kaburaki Toshikatsu | Goto Hiroshi | Sonoda Koh-Hei | Namba Kenichi | Mizuki Nobuhisa | Mochizuki Manabu Publishers : 日本眼科学会 Date Issued : 2013-01

Esophageal squamous papilloma with tentacular processes

Gastrointestinal endoscopy Volume 74 Issue 5

Creators : Nakamura Munetaka | Okamoto Takeshi | Kiyotoki Shu | Saito Mari | Hamabe Kouichi | Nishikawa Jun | Sakaida Isao Publishers : American Society for Gastrointestinal Endoscopy Date Issued : 2011-11

Current status of sentinel lymph node biopsy with CT lymphography for breast cancer

Japanese journal of clinical radiology Volume 57 Issue 12

Creators : 菅一能 | 山本滋 | 前田訓子 | 長島由紀子 | 為佐路子 | 井上由佳 | 岡正朗 Publishers : 金原出版 Date Issued : 2012-11-10

Usefulness and pitfalls of fluorine-18-fluorodeoxyglucose positron emission tomography for the detection and assessment of orbital tumors and Inflammatory/granulomatous disorders

Japanese journal of clinical radiology Volume 57 Issue 12

Creators : 菅一能 | 松永尚文 | 梶原浩司 | 大石真理子 | 藤岡裕士 Publishers : 金原出版 Date Issued : 2012-11

Spectrum of CT finding in aortic aneurysm

Japanese journal of clinical radiology Volume 58 Issue 1

Creators : 岡田宗正 | 松永尚文 | 中島好晃 | 國弘佳枝 Publishers : 金原出版 Date Issued : 2013-01

Severity evaluation of pulmonary emboli using three-dimensional dual-energy perfusion CT

Japanese journal of clinical radiology Volume 58 Issue 1

Creators : 岡田宗正 | 国弘佳枝 | 中島好晃 | 佐野祐一 | 松永尚文 Publishers : 金原出版 Date Issued : 2013-01

A case of facial asymmetry due to condylar hyperplasia- a treatment strategy for active condylar hyperplasia-

The bulletin of the Yamaguchi Medical School Volume 59 Issue 3-4

Creators : Nakano Hiroyuki | Mano Takamitsu | Mishima Katsuaki | Kishi Masami | Horinaga Daijyu | Miyawaki Yuichiro | Mori Yoshihide | Ueyama Yoshiya Publishers : Yamaguchi University School of Medicine Date Issued : 2012

Filipino-type β^0-thalassemia has 116 kb deletion: its correct breakpoints and five cases found in Japan

The bulletin of the Yamaguchi Medical School Volume 59 Issue 3-4

Creators : Yamashiro Yasuhiro | Hattori Yukio | Nitta Takenori | Adhiyanto Chris | Matar Maryam M. | Ferania Mella | Takagi Fumiya Publishers : Yamaguchi University School of Medicine Date Issued : 2012

Melatonin protects oocyte from reactive oxygen species

The bulletin of the Yamaguchi Medical School Volume 59 Issue 3-4

Creators : Tamura Hiroshi | Takasaki Akihisa | Taketani Toshiaki | Tanabe Manabu　 | Kizuka Fumie | Lee Lifa | Tamura Isao | Maekawa Ryo | Aasada Hiromi | Yamagata Yoshiaki | Sugino Norihiro Publishers : Yamaguchi University School of Medicine Date Issued : 2012

In vivo real-time monitoring and evaluation for superoxide anion radical generation with an electrochemical sensor

The bulletin of the Yamaguchi Medical School Volume 59 Issue 3-4

Creators : Fujita Motoki | Maekawa Tsuyoshi | Todani Masaki | Tsuruta Ryosuke Publishers : Yamaguchi University School of Medicine Date Issued : 2012

Mutation-linked defective inter-domain interactions within ryanodine receptor as a pathogenic mechanism of catecholaminergic polymorphic ventricular tachycardia

The bulletin of the Yamaguchi Medical School Volume 59 Issue 3-4

Catecholaminergic polymorphic ventricular tachycardia (CPVT) is an inherited disease characterized by stress- or exercise- induced ventricular tachycardia, frequently leading to sudden cardiac death. A considerable body of evidence accumulated over recent years suggests that mutation-linked cardiac ryanodine receptor (RyR2) defects cause Ca^2+ leak from sarcoplasmic reticulum, which triggers delayed afterdepolarization and leads to CPVT. However, the underlying mechanism, by which a single mutation in such a large molecule causes drastic effects on the channel function, remains elusive. Here we report that introduction of a human CPVT mutation S2246L into the mouse RyR2 induces aberrant activation of channel gating by forming abnormally tight domain-domain interaction between the S2246L mutable domain and the K201-binding domain. This produces more global conformational change in the RyR2: namely, an aberrant domain unzipping between the N-terminal (a.a. 1–600) domain and the central (a.a. 2000–2500) domain owing to the allosteric conformational coupling mechanism. Pharmacological correction of the defective inter-domain interactions can stop the aberrant Ca^2+ release and lethal arrhythmia. These results provide a new pathogenic mechanism of CPVT and a novel therapeutic strategy against CPVT

Creators : Suetomi Takeshi | Yano Masafumi | Matsuzaki Masanori Publishers : Yamaguchi University School of Medicine Date Issued : 2012

The safety of amiodarone for heart failure patients with atrial fibrillation

Journal of arrhythmia Volume 27

Creators : Hiratsuka Atsushi | Smizu Akihiko | Ueyama Takeshi | Doi Masahiro | Yoshida Masaaki | Fukuda Masakazu | Kato Takayoshi | Fumimoto Tomoko | Matsuzaki Masunori Publishers : 日本心臓ペーシング・電気生理学会 Date Issued : 2011

Nippon storm study design

Journal of arrhythmia Volume 28 Issue 5

Creators : Kurita Takashi | Noda Takashi | Nitta Takashi | Furushima Hiroshi | Shimizu Akihiko | Ohe Tohru | Aizawa Yoshifusa | Chiba Yasutaka Publishers : 日本心臓ペーシング・電気生理学会 Date Issued : 2012-10

Yolk sac tumor of the bilateral basal ganglia in a patient with Down syndrome

Brain tumor pathology

Creators : Sugimoto Kazutaka | Ideguchi Makoto | Sadahiro Hirokazu | Yoshikawa Koichi | Goto Hisaharu | Nomura Sadahiro | Fujii Masami | Suzuki Michiyasu Publishers : Springer-Verlag Tokyo Date Issued : 2013-01-11

Trial and development of effective instructional materials for echocardiography

Japanese journal of medical ultrasonics Volume 39 Issue 4

Creators : Suenaga Hiromi | Momose Nagisa | Kobayashi Yuki | Syukuwa Yuko Publishers : 日本超音波医学会 Date Issued : 2012-07-15

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