Effects of Lidocaine on Cerebral Energy State and Glycolytic Metabolism in the Rat

Contractile responses of rabbit aortic strips to transmural stimulation and to exogenously applied norepinephrine (NE), potassium chloride (KCl), and histamine were studied in the presence of lidocaine or its metabolite, glycinexylidide (GX). Lidocine, 10^-4 and 5×10^-4M, attenuated the contractile response to transmural stimulation. GX, 2×10^-5 to 5×10^-4M, potentiated the response to transmural stimulation. The suppression induced by lidocaine was not reversed by excess calcium, 2.2 and 4.4 mM, but was partially reversed by cocaine, 3×10^-6M. Lidocaine, 5×10^-4M shifted the dose-response curve of NE to the right, whereas GX, 5×10^-4M, shifted the curve to the left. The maximum tension developed by K^+ was attenuated by lidocaine, 5×10^-4M, and GX, 2×10^-3M. It may be condcluded that lidocaine attenuates the response to stimulation of sympathetic nerves innervating the arterial wall by interfering with the release of NE. In contrast, GX potentiates the response, possibly by increaseing the release of NE.

lidocaine

seizure

carebral metabolism

electroencephalography