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Body composition as a novel prognostic biomarker for the patients with advanced hepatocellular carcinoma

山口医学 Volume 70 Issue 4

Creators : Saeki Issei Publishers : 山口大学医学会 Date Issued : 2021-12-02

Novel mechanisms regulating myogenic differentiation in skeletal muscle

山口医学 Volume 70 Issue 4

Creators : Honda Takeshi Publishers : 山口大学医学会 Date Issued : 2021-12-02

Liquid biopsy test based on a sensitive dna methylation assay for diagnosing hepatocellular carcinoma : which is a better marker, methylated sst or sept9?

山口医学 Volume 70 Issue 3

We performed this study to investigate whether serum cell-free DNA testing(liquid biopsy)of either methylated SEPT9 or methylated SST, which are possible biomarkers of HCC, in combination with AFP may improve clinical performance for the detection of HCC. Study subjects included 25 healthy controls, 15 patients with chronic liver disease without HCC, and 38 patients with HCC. Methylation level of serum cell-free SEPT9 and SST was measured by methylation-sensitive restriction enzymes followed by multiplex droplet digital polymerase chain reaction. According to receiver operating characteristic curve analysis to discriminate between non-HCC group(including control group and chronic liver disease without HCC group)and HCC group, area under the curve(AUC)was 0.73 by AFP and 0.73 by mSEPT9, whereas it was only 0.59 by mSST. Regarding combination tests, although negative predictive values were almost same between the AFP + mSEPT9 test and the AFP + mSST test(75.0% vs 72.2%),a positive predictive value of AFP + mSEPT9 test was higher than that of the AFP + mSST test(79.4% vs. 66.7%).In conclusions, methylated SEPT9 was a better companion marker of AFP for HCC screening than methylated SST.

Creators : Yamasaki Ayano | Suehiro Yutaka | Hoshida Tomomi | Saeki Issei | Yamauchi Kotoh Yurika | Matsumoto Toshihiko | Takami Taro | Sakaida Isao | Yamasaki Takahiro Publishers : 山口大学医学会 Date Issued : 2021-09-01

Investigation of the factors of attendance and continuous to participate in dementia café among community-dwelling seniors

山口医学 Volume 70 Issue 2

Creators : Fujimura Kazumi | Hase Ryosuke | Kijima Ayano | Okochi Ayako | Kumagai Tamaki Publishers : 山口大学医学会 Date Issued : 2021-05-13

Sterile inflammation as a novel therapeutic target to heart failure

山口医学 Volume 70 Issue 2

Creators : Suetomi Takeshi Publishers : 山口大学医学会 Date Issued : 2021-05-13

Nobiletin, a citrus flavonoid, suppresses SPC-induced abnormal vascular contraction

山口医学 Volume 70 Issue 1

Creators : Miyanari Kenji Publishers : 山口大学医学会 Date Issued : 2021-03-04

A case of raspberry-like foveolar-type gastric adenocarcinoma resected by strip biopsy

山口医学 Volume 70 Issue 1

Creators : Fujimura Hiroyuki | Nishikawa Jun | Hamabe Koichi | Izumiya Yuta | Matsumoto Satoko | Yoshitomi Shingo | Ito Shunsuke | Yamaoka Yuko | Shirasawa Tomohiro | Goto Atsushi | Hashimoto Shinichi | Okamoto Takeshi | Hoshii Yoshinobu | Sakaida Isao Publishers : 山口大学医学会 Date Issued : 2021-03-04

The different effects of acacetin and biochanin A on abnormal contraction of vascular smooth muscle

山口医学 Volume 70 Issue 1

Creators : Zhang Min Publishers : 山口大学医学会 Date Issued : 2021-03-04

Paroxysmal sympathetic hyperactivity after traumatic brain injury experienced in Yamaguchi University

山口医学 Volume 70 Issue 1

Creators : Fujiyama Yuichi Publishers : 山口大学医学会 Date Issued : 2021-03-04

Rapid and sensitive detection of UGT1A1 polymorphisms associated with irinotecan toxicity by a novel DNA microarray

山口医学 Volume 69 Issue 4

Creators : Tsunedomi Ryouichi Publishers : 山口大学医学会 Date Issued : 2020-12-25

Intraoperative anaphylactic shock related to fibrin glue application during video-assisted thoracoscopic surgery

山口医学 Volume 69 Issue 3

Creators : Yano Yuka | Kuga Takayuki | Sakamoto Ryuunosuke | Shigeta Masatoshi | Iida Yasuhiko Publishers : 山口大学医学会 Date Issued : 2020-09-25

Current status of rifaximin treatment for hepatic encephalopathy at our hospital

山口医学 Volume 69 Issue 2

Creators : Iwamoto Takuya | Sakaida Isao Publishers : 山口大学医学会 Date Issued : 2020-05-01

Bartonella henselae DNA in seronegative patients with cat-scratch disease

山口医学 Volume 69 Issue 1

Creators : Yanagihara Masashi Publishers : 山口大学医学会 Date Issued : 2020-02-28

Problems in expert scientific testimony on alcohol-related crimes

Acta criminologiae et medicinae legalis Japonica Volume 85 Issue 4

Creators : Fujimiya Tatsuya | Himemiya-Hakucho Ayako Publishers : 日本犯罪學會 Date Issued : 2019-12

Current status for recent 3 years and future issues of introductory medicine for first grade medical students

山口医学 Volume 68 Issue 4

Creators : Nishimoto Arata | Hisanaga Takuro | Katsura Shunsaku | Fujimiya Tatsuya | Shirasawa Bungo Publishers : 山口大学医学会 Date Issued : 2019-12-11

The validation of a no-drain policy after thoracoscopic major lung resection

山口医学 Volume 68 Issue 4

Creators : Murakami Junichi Publishers : 山口大学医学会 Date Issued : 2019-12-11

Forensic pharmacokinetics of alcohol and its metabolites for the purpose of expert witness testimony

法医学の実際と研究 Volume 61

Creators : Fujimiya Tatsuya Publishers : 法医学談話会 Date Issued : 2018

Changes of student’s questionnaire evaluation after practice with expanded clinical clerkship

山口医学 Volume 68 Issue 2-3

Creators : Hisanaga Takuro | Katsura Shunsaku | Nishimoto Arata | Fujimiya Tatsuya | Shirasawa Bungo Publishers : 山口大学医学会 Date Issued : 2019-08-09

Jejunal gastrointestinal stromal tumor(gist) : A report of four cases

山口医学 Volume 68 Issue 1

Creators : Nakamura Takashi | Sakano Hisashi | Kudo Junichi | Matsumoto Masaharu | Nakamura Munetaka | Yoneshiro Shigeru | Kuga Takayuki | Itoh Hiroshi | Hamano Kimikazu Publishers : 山口大学医学会 Date Issued : 2019-03-01

Importance of cancer screening check-up encouragement to senior citizens after retirement : Based on analysis of Yamaguchi Prefecture cancer registration 2008-2014

山口医学 Volume 68 Issue 1

Creators : Sunagawa Hiroshi Publishers : 山口大学医学会 Date Issued : 2019-03-01

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