Effects of Synthetic Peptide, Leu-Leu-Lys-Asp-Leu, on the Growth Hormone Induced Lipolysis

In order to explain the mechanism of the lipolysis induced by the growth hormone, several Lys-Asp derivatives have been synthesized and examined the lipolytic activity to the epididymal adipose tissue of rats. Lys-Asp derivatives having either alph-or epsilon-amino group at the N-terminal and carboxyl groups at the C-terminal were concerned to the lipolytic action. This activity was emphasized by allowance of appropriate hydrophobicity. A peptide suited to such conditions was conceived to be Leu-Leu-Lys-Asp-Leu whose sequence was found in the amino acid sequence of boving growth hormone. Therefore, it was suggested that peptide might have the lipolytic activity. Then a peptide, Leu-Leu-Lys-Asp-Leu, was synthesized by the stepwise method and